Prematurely born neonates require, amongst others, pharmaceutical therapy. Dosing guidelines for these therapies are often based on data from term born neonates or older infants, while these are not necessarily similar to prematurely born neonates.

Promotor: W. Jiskoot, Co-promotor: A. Hawe

Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: Dr. A. El Ghalbzouri

The division of BioTherapeutics consists of the former divisions Biopharmaceutics and Drug Delivery Technology.

The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.

Death in all types of melanomas is generally caused by metastasis. Uveal melanoma (UM) is the most common intraocular melanoma, there are currently no (patient-derived) animal models that faithfully recapitulate metastatic dissemination of UM.

Bet v1, the major allergen in birch pollen, is one of the main causes of allergies such as asthma and rhino-conjunctivitis. Additionally it is the main cause of birch pollen allergy in humans.

On Tuesday 30 April 2024 Jonny Russell successfully defended a doctoral thesis and graduated.

Actinobacteria are well known for the production of bioactive natural products, many of which have applications in the fields of human, animal and plant health. Subject of this thesis are the anthracyclines, glycosylated aromatic polyketides with potent anticancer activity.

Antibiotic resistance, caused by widespread use of antibiotics, leads to bacterial infections that are difficult, if not impossible, to treat and is a major worldwide health concern.

Cardiovascular disease is a major global burden and atherosclerosis is the main underlying pathological process.

Atherosclerosis is the most important underlying process that drives cardiovascular disease, and is characterized by an accumulation of cholesterol which triggers an inflammatory response in the vessel wall.

Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…

Nietzsche's famous notion 'amor fati' is often associated with the Stoic maxim to 'live in accordance with nature'; we have to fully accept our fates in order to attain happiness. But is happiness really what Nietzsche's 'amor fati' is about? And how to account for all the fiercely critical remarks…

Acute cardiovascular syndromes, including myocardial infarction or stroke, are the principal cause of death in the Western society. The main underlying pathology of cardiovascular diseases is atherosclerosis, which is caused by the accumulation of lipids and inflammatory cells in the vessel wall, in…

Sepsis is a life-threatening condition caused by a dysregulated host response to infection, it is associated with significant morbidity, mortality, and with a high financial burden on global healthcare systems. Bacterial infections are the primary cause of sepsis, but the growing prevalence of antimicrobial…

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Microscopic insight on lipid-based nanomedicine in vivo remains limited to the perception of the knowledge that could be obtained: if we interpret only what we see, then we only believe to know. Although believing to know encapsulates an undefined amount of uncertainty in the exploration of lipid-based…

Promotor: Prof.dr. M. Danhof

β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…

Eduard Fosch-Villaronga and Hadassah Drukarch from eLaw - Center for Law and Digital Technologies, recently published the book ‘AI for Healthcare Robotics’, published by CRC Press from Taylor and Francis Group in their AI for Everything Series.

This focus area adresses the mental well-being of people of all ages, from infants to the elderly. The emphasis lies on understanding, preventing, and treating mental health problems in a variety of contexts, such as the family, school, and work environment. We carry leading research and education programmes…

‘Regenerative medicine’ explores ways to repair or replace damaged cells, tissues and organs with cell, stem-cell or gene therapy. It can lead to valuable breakthroughs in the treatment of chronic diseases such as diabetes, heart problems and kidney diseases or muscle diseases.

Key publications of the Analytical BioSciences and Metabolomics group

Leiden University seeks to bring knowledge, academic top talents, and resources from Leiden and Latin America and the Caribbean together in mutually beneficial joint research projects that are content-driven, based on existing excellent research. Connecting research and researchers.

Inflammatory skin diseases such as psoriasis and atopic dermatitis can severely impact both the physical and social aspect of a patient’s life. Aberrant inflammatory responses are thought to be a major causative factor in these disorders, but an abundance of different factors contribute to the development…

Biotherapeutics or biologics, such as proteins, peptides, and nucleic acids, comprise an increasing share of the pharmaceutical market, whilst offering new therapies for difficult-to-treat diseases. Most notable is their contribution to the vaccination efforts during the COVID-19 pandemic. In most cases,…

Atherosclerosis is a chronic inflammatory disease affecting millions of people world-wide.

Kinase inhibitors are key therapeutic agents, particularly in oncology, yet their clinical efficacy is often hampered by off-target effects and limited understanding of their cellular target profiles.

These awards honour researchers who turn scientific insight into real-world impact. From master’s students to postdocs, they highlight exceptional work in life sciences, health sciences, biotech, or environmental health sciences with data science at the core. Meet the 2025 winners.

This work describes the use of click-to-release chemistry to get spatiotemporal control over immunocytokine activity. Until now, immunocytokines (cytokines coupled to a tumor-targeting-moiety) remained active throughout the body, being able to bind their respective receptors, causing mild to severe…

This thesis advances our understanding of lipid uptake, a vital first step in lipid metabolism, by developing innovative click chemistry-based tools to study how immune cells internalize lipids.

Neurodegenerative diseases pose a large medical and societal challenge. The etiology of these diseases is still poorly understood, which makes drug discovery for these diseases difficult.

How are new drugs developed? This question is central to the Minor Modern Drug Discovery (MDD), which covers the entire trajectory from disease to drug molecule and vice versa. The various research groups involved offer a complementary and interdisciplinary perspective by connecting the diverse subjects…

Adults who were abused or mistreated as a child and consequently suffer from post-traumatic stress disorder (PTSD) can benefit greatly from cognitive behavioural therapy. This is the conclusion of a study of 149 patients. Researcher and PhD candidate Chris Hoeboer is hopeful about the results and the…

We invite proposals for special sessions on interdisciplinary, under-studied, and emerging topics (deadline passed).

Food relations (through production, distribution, circulation, exchange and waste) represent the embodiment of our relation to the environment.

Members of our research team give different types of presentations and lectures.

The 9th Network Europe Conference in Edinburgh was held at June 2017 in Edinburgh and organized by the Europa Institut Zurich. The contributions of the conference are now published.

Leiden PhD student Xuequan Zhou has designed a new promising molecule that efficiently kills cancer cells, but does not harm healthy tissue. The trick: the drug is only active when irradiated with light. Zhou’s new compound does this extra efficiently by cleverly self-organising into nanoparticles.…

This book surveys a distinct human phenomenon in the history of the ancient Near East: individuals who were born males but, under various social and historical circumstances, their masculine identity was considered ambiguous. They bore specific titles and were engaged in cult or palace administration.…

The WIIS-NL blog provides articles on gendered international security issues taking a multi-disciplinary approach which includes but is not limited to WIIS focus areas. This blog aims to reach a broad audience of academics, practitioners, students, and interested members of the general public.

Do you often find yourself exhausted in the lecture hall or at your workplace? Not great for your mental well-being, as Laura Pape knows. She is investigating how an online self-help program can assist in addressing sleep issues and preventing mental health problems. Join her on this elevator pitch…

PhD defence

PhD defence

PhD defence