The focus of the described research in this thesis is on the oxidative stress response (Nrf2 pathway). The aim of the research presented in this thesis is to obtain more information concerning microRNAs which are involved in the Nrf2 pathway, to determine and evaluate the application of microRNAs for…

This project aims at providing a broad perspective of the state of Science Technology and Innovation (STI) in Africa with a focus on global funding flows, in order to inform research funders in the continent, in particular those participating in the Science Granting Councils Initiative (SGCI). The project…

Leiden molecular cell biologists in the research group of Annemarie Meijer have discovered novel early macrophage-specific genes in zebrafish, including a signal transducer pivotal for the migration of macrophages in the innate immune response to bacterial infection. Their findings were published on…

The adsorption of D2 and CO2 on catalyst surfaces is studied using a molecular beam in ultra-high vacuum.

Smart digital infrastructures predicated on myriads of sensors distributed in the environment are often rendered as key to contemporary urban security governance to detect risky or suspicious entities before or during a criminal event takes place. At the same time, they often involve surveillance of…

Leiden chemists, together with colleagues at the University of York (UK) and Technion (Israel) have discovered a small, sugar-like molecule that maintains the integrity of tissue around a tumour during cancer. This molecule prevents tumour cells from spreading from the primary cancer site to colonise…

The upscaling of Life Cycle Assessment (LCA) data is recognized as one of the main challenges in the ex-ante LCA of emerging technologies. This challenge arises since industrial-scale system specifications for these technologies are unknown and industrial data is lacking.

On 20 March 2019, Tim Dekkers defended his thesis 'Mobility, Control and Technology in Border Areas: Discretion and Decision-making in the Information Age'. The doctoral research was supervised by Prof. dr. J.P. van der Leun en Prof. dr. M.A.H. van der Woude.

Leiden physicists are helping Wageningen plant researchers to study unpredictable plant embryos. For this, they are using a novel two-photon fluorescence microscope, aided by a 30 thousand euro ZonMW grant.

An international group of scientists has discovered that certain cells of our immune system – the so-called T cells – communicate with each other and work together as a team. To fight an infection they stimulate each other’s growth, but at the same time, they inhibit each other when there is a surplus…

Technologies that help to enhance our educational environments can be found everywhere.

Joost Beltman is assistant professor at the Division of Drug Discovery & Safety.

Tessa Vergroesen is a PhD student at the Institute of Biology Leiden. In the Mathematical Biology group she is working on the experimental side of the research projects on angiogenesis, investigating effects of modifications of the extracellular matrix on in vitro and in vivo structures of new blood…

This edited volume provides a synthesis on the question of business attitudes towards and its influence over the development of the modern welfare state. It gathers leading scholars in the field to offer both in-depth historical country case studies and comparative chapters that discuss contemporary…

With the necessary measures, researchers restart their work in various laboratories. The Leiden Cell Observatory is one of the places where scientists resume their lab work.

This project explored the role of material culture, in casu painted plaster and its technologies, in expressing dynamic social identities and in forging complex interwoven human relationships in the context of the Middle to Late Bronze Age of the Aegean and East Mediterranean.

When the immune system attacks cancer, the tumour modifies itself to escape the immune reaction. Researchers at LUMC published on this subject in Nature on 28 June.

On 22 June, Najib Amin defended the thesis 'State-building, lawmaking, and criminal justice in Afghanistan: a case study of the prison system’s legal mandate, and the rehabilitation programmes in Pul-e-charkhi prison'. The doctoral research was supervised by Jan Michiel Otto and Pauline Schuyt.

Practical applications for the reconstruction of the past

Cathodic corrosion for producing nanoparticles was (re)discovered when trying to control the electrochemical etching of a scanning tunneling microscopy (STM) tip.

Subproject of

Are Weyl particles the ideal conductors? Do cells without a cell wall play a role in chronic Tuberculosis infections? Carlo Beenakker and Dennis Claessen want to answer these questions. They both received a KLEIN grant from the NWO. With these grants, NWO wants to stimulate innovative, fundamental r…

Three speakers, three fascinating science stories and a well-filled lecture hall. The Niko Tinbergen Lecture had a successful restart on 10 December 2019.

The research addresses the question of “what is the impact of geopolitical changes to the pivot states in the Middle East? With special focus on Turkey, Iran and Saudi Arabia.”

This book offers a comprehensive analysis of China's global resurgence and its effects on U.S. dominance.

Cardiovascular diseases are the primary cause of death in the world with atherosclerosis as primary underlying cause.

Researchers from the Netherlands Cancer Institute, the Leiden University Medical Center (LUMC) and Oncode have created a tracking system that can reveal how often cells have divided. This allowed them to find a yet undiscovered population of immune cells: young memory cells that behave like stem cells.…

Researchers from Leiden University Medical Center (LUMC) and Netherlands Cancer Institute (NKI) have discovered how specialised immune cells can detect and remove cancers that are ‘invisible’ to the conventional defence mechanisms of the immune system. Their work has been published in Nature. The findings…

Joost Beltman (LACDR, Leiden University) has provided novel insights in the way T cells migrate towards virus-infected cells. This was accomplished by a combination of experimental research in the group of Ton Schumacher (Dutch Cancer Institute, NKI) and computer simulations in collaboration with Rob…

Does foreign aid promote human rights?

Ramesh Ganohariti will examine legal identity in three post-Soviet aspirant states and outline four common scenarios in this article.

My research is focused on the host-pathogen interplay during infection in Mycobacterium avium and comparing with better studied mycobacterial pathogens like M. tuberculosis and M. marinum. My work addresses two crucial processes in mycobacterial pathogenesis: the intracellular trafficking inside macrophages…

Our research is aimed at understanding the factors involved in creating cell wall-deficient cells. We investigate the bacterial stress responses to identify the mechanism and genomic alterations behind switching between the walled to wall-less state. With this project, we contribute towards novel treatment…

Lipid nanoparticles (LNPs) have enabled the success of mRNA vaccines but remain limited in broader therapeutic use by challenges in delivery efficiency, targeting, and mechanistic understanding.

The main aim of the project is to collect and update on a regular basis bibliometric and patent indicators that can be used to underpin and inform analyses pursued at the European Commission (EC) to assess European and national scientific and technological performance.

American pharmaceutical company Bristol Myers Squibb will be building a new (CAR-T) cell therapy facility in the Oegstgeest part of the Leiden Bio Science Park. The company will manufacture and develop CAR T-cell therapy for patients with blood cancer (leukaemia), for example.

Mechanics play a larger role in blood vessel formation, and other developmental biology, than previously thought. Cells appear to respond to mechanical signals, such as pressure. Through the extracellular matrix, a network of fibrous proteins, cells can supposedly exchange those mechanical signals over…

Promotor: T. Schmidt

A single self-assembled semiconductor quantum dot in a high-finesse optical microcavity - the subject of this thesis - is an interesting quantum-mechanical system for future quantum applications. For instance, this system allows trapping of an extra electron and thus can serve as a spin quantum memory,…

On 28 February 2019, Kabir Duggal defended his thesis 'Principles of Evidence in Investor-State Arbitration, Burden, Standards, Presumptions & Inferences'. The doctoral research was supervised by Prof. dr. E. De Brabandere.

In this article, the authors explore why there is substantial cross-national variation in the level of regulatory clarity surrounding cryptocurrencies

In breast cancer, metastasis rather than the primary tumour is the cause of death. A lack of oxygen in the tumour cells promotes this metastasis, accompanied by a reprogramming of the cell's metabolism. PhD candidate Qiuyu Liu investigated these alterations to get more knowledge about the actionable…

The authors explore the decision-making processes and debates surrounding EU member states' troop contributions to CSDP military deployments.

In this book, Lydie Cabane examines the history of disaster management in South Africa.

Light can be used to apply forces on single cells. Focused lasers have been used by physicists to tweeze particles and to manipulate them. These so called “optical tweezers” can be used as mechanical phenotyping tools for characterising the mechanics of materials and living objects.