Promotor: A. Doelman, Co-promotores: P.J.A. van Heijster; A. Zagaris

Detecting nanoscopic objects plays an important role in nanoscience in particular, in the rapidly growing field of nanobiology. The forebear to modern super-resolution microscopy for single molecule investigation, is fluorescence microscopy.

Formulation of biopharmaceuticals

Given the accelerating appearance of antimicrobial resistance, there is an urgent need for more fundamental research into novel antibiotic strategies. The work in this thesis helps to address this global problem by developing new antibiotic compounds, inspired by the antibacterial mechanisms of the…

The research of the Biotherapeutic Delivery group led by Joachim Van Guyse focuses on developing novel polymer-based formulations for therapeutic nucleic acid and protein delivery. The research revolves around developing structure-activity relationships between the chemical structure of polymers, the…

The thesis focuses on synthesis strategies in oligosaccharide campaigns, and the influence of protecting groups.

Promotor: G. A. van der Marel, Co-promotor: D. V. Filippov

There is a need for alternative methods to replace, reduce and refine (3R) animal experimentation. Combining experimental data from high-throughput in vitro studies with in silico modeling is a promising approach to unravel the effect of chemicals on living cells and to gain a better understanding of…

Many biological processes occur by biomolecules coming together and organizing into specific clusters without being bound to each other. These interactions range from clustering, transiently interacting (kiss and run), or assembling to multimeric units that can only function in conjunction. The hydrogen…

We are a community of researchers from diverse backgrounds who explore becoming and being human, in relation to the world around us and other living beings.

Transcutaneous vaccination is attractive because it is non- or minimally invasive, pain free and the site of administration (skin) is easily accessible. What’s more, transcutaneous immunization can lead to a strong immune response owing to the presence of immune-competent cells in the skin.

Are you interested in an interactive Master’s programme that prepares you for important roles in the innovations of our future healthcare? The Health, Ageing and Society Master’s focuses on biological, individual and social aspects of healthy ageing, as well as emphasizing on personal and professional…

Are you interested in an interactive Master’s programme that prepares you for important roles in the innovations of our future healthcare? The Health, Ageing and Society Master’s focuses on biological, individual and social aspects of healthy ageing, as well as emphasizing on personal and professional…

This multidisciplinary minor addresses the fascinating question how we, modern humans, got to be the way we are. Who were our ancestors? How does our morphology, genetic makeup, brain and behaviour relate to that of other species? How does our evolutionary past affect our susceptibility to diseases?…

When you stretch an elastic band, it gets longer. But imagine a material that actually becomes shorter when you pull on it. Sounds strange, doesn’t it? Yet that’s exactly what physicists from Leiden University, AMOLF, and ARCNL have managed to create.

Research on this theme addresses the systemic risks faced by European societies and affecting the quality of life of European citizens.

All languages use melody in speech, primarily via rises and falls of the pitch of voice. Such pitch variation is pervasive, offering a wide spectrum of nuance to sentences – an additional layer of meaning. For example, saying “yes” with a rising pitch implies a question (rather than an affirmation).…

Our team consists of the following members.

The more complex the object, the harder it is to fold up. Space satellites often need many small motors to fold up an instrument, and people have difficulty simply folding up a roadmap. Physicists from Leiden and Amsterdam have now designed a structure that folds itself up in several steps. Publication…

Water droplets float in a hot pan because of the so-called Leidenfrost effect. Now physicists have discovered a variation: the Elastic Leidenfrost effect. It explains why hydrogel balls jump around on a hot plate making high pitched sounds. Publication in Nature Physics on July 24.

The Developmental and Educational Psychology unit nominated Jiemiao Chen's paper

In the research theme ‘Animal Sciences and Health’, we work with various animal species to gain insights into fundamental biological processes in both animals and humans.

Metal-containing molecules combine geometrical features and a reactivity that are inherently different from that of organic molecules. My research focuses on light-activatable metal-based anticancer drugs and metal-functionalized liposomes. Light is a very selective way to activate photosensitive drugs…

Huub de Groot is professor in Biophysical Organic Chemistry. With his team he works in the field of photosynthesis and artificial photosynthesis. The molecular basis for photosynthesis is formed by protein complexes and organelles that contain chlorophyll molecules. The antenna systems herein capture…

In this research group, led by Dr. Joost Beltman, the aim is to employ mathematical and computational dynamical modelling approaches in order to quantitatively and mechanistically understand the dynamical behaviour and regulation of intracellular networks of genes, proteins and metabolites as well as…

How do people develop and how do they learn? How does their environment affect them? How do we ensure that they develop in optimal fashion? And what can we do if problems occur? These are questions that the researchers at the Institute of Education and Child Studies try to answer.

The research conducted at the Leiden Academic Centre for Drug Research is clustered within the divisions of BioTherapeutics, Cell Systems and Drug Safety, Medicinal Chemistry and Systems Pharmacology and Pharmacy, and the Metabolomics and Analytics Centre.

Is system thinking through perspectives the solution for biology education to help students see the connections between different topics?

Social anxiety runs in families, but the neurobiology underlying this genetic vulnerability is until now largely unknown. The unique Leiden Family Lab study on Social Anxiety Disorder (LFLSAD) aims to broaden our knowledge with respect to this genetic susceptibility.

The group of Dr. Roxanne Kieltyka designs and synthesizes molecules that self-assemble into polymeric materials using specific non-covalent interactions. These substrates can be used for numerous applications in medicine ranging from disease detection to cell delivery depending on the (bio)molecular…

Management of Impacts on Biodiversity: What are the effects of light pollution from cities and bridges and noise pollution from passing vessels and nearby road traffic on migratory fish passage and spawning in rivers?

Combining different disciplines, researchers work together to formulate innovative solutions to societal problems.

The researchers at the Institute of Education and Child Studies focus on child rearing and the development of children and adolescents with and without developmental and other problems, in biological and non-biological families, childcare, education and care institutions.

Researchers of the National University of Singapore and Leiden University have discovered that chimpanzees and bonobos share the contrasting colour pattern seen in human eyes, which makes it easy for them to detect the direction of someone’s gaze from a distance.

Providing each cancer patient with the right treatment remains a challenge. Oncode Accelerator aims to change this by innovating the way we develop cancer treatments, thus ensuring the patient is at the heart of the process. Leiden University, the LUMC and other partners will implement this new way…

A full overview of MCBIM PhD theses.

Physicists at the Leiden Institute of Physics (LION) conduct fundamental research into physical phenomena. They are inspired by curiosity and the desire to know more about the world in which we live. This research has always paved the way for new practical applications. These are something that the…

Education & outreach

Human activity, such as pollution, may disturb the balance of living water systems, which has consequences for biodiversity, but also for other functions such as water purification. Leiden University maps living water systems using the most advanced technologies.

We study the structure, dynamics and physics of complex networks emerging from the intricate interconnectedness of the constituents of large systems.

The knowledge and skills you will acquire will qualify you for many different jobs. Possible careers include: researcher of learning, behavioural and emotional problems in children, or designer of prevention and intervention programmes.