We use DNA strands to stabilize few-atom silver clusters, which show unique optical and chemical properties. This thesis involves the study of these constructs for various applications.

Formulation of biopharmaceuticals

Detecting nanoscopic objects plays an important role in nanoscience in particular, in the rapidly growing field of nanobiology. The forebear to modern super-resolution microscopy for single molecule investigation, is fluorescence microscopy.

Transcutaneous vaccination is attractive because it is non- or minimally invasive, pain free and the site of administration (skin) is easily accessible. What’s more, transcutaneous immunization can lead to a strong immune response owing to the presence of immune-competent cells in the skin.

The cannabinoid CB2 receptor (CB2R) represents a promising therapeutic target for various forms of tissue injury and inflammatory diseases. Although numerous compounds have been developed and widely used to target CB2R, their selectivity, molecular mode of action and pharmacokinetic properties have…

Aluminium-based adjuvants, such as aluminium hydroxide and aluminium phosphate, are well-known for their immune-stimulating properties.

Promotor: A. Doelman, Co-promotores: P.J.A. van Heijster; A. Zagaris

Appropriate animal models for intradermal vaccine delivery are scarce. Given the high similarity of their skin anatomy to that of humans, minipigs may be a suitable model for dermal vaccine delivery.

Find out about the effects of Brexit on contracts and supplies.

Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction.

Given the accelerating appearance of antimicrobial resistance, there is an urgent need for more fundamental research into novel antibiotic strategies. The work in this thesis helps to address this global problem by developing new antibiotic compounds, inspired by the antibacterial mechanisms of the…

Key publications of the Biomedical Microscale Analytics group.

The objective is to develop in vitro antigen degradation assays in order to mimic the fate of the antigen in vivo.

In the traditional theory of linear elasticity, superposition dictates that the response of a material does not depend on the sequence of the applied mechanical actuations.

Because thin systems can deform along the thickness with relative ease, the interplay between surface mechanics and geometry plays a fundamental role in sculpting their three-dimensional shape.

In photoactivated chemotherapy (PACT), a biologically active compound is caged by a light-cleavable protecting group.

Promotor: G. A. van der Marel, Co-promotor: D. V. Filippov

The research of the Biotherapeutic Delivery group led by Joachim Van Guyse focuses on developing novel polymer-based formulations for therapeutic nucleic acid and protein delivery. The research revolves around developing structure-activity relationships between the chemical structure of polymers, the…

Vaccination is the most effective method to prevent influenza infection. However, current influenza vaccines have several limitations. Relatively long production times, limited vaccine capacity, moderate efficacy in certain populations and lack of cross-reactivity are important issues that need to be…

Mechanical metamaterials are carefully engineered materials whose properties are controlled by their structure, not by their composition, which allows using metamaterials to study and control physical effects in detail⁠.

Lipid signaling is an essential biological event/process in a plethora of pathophysiological conditions. The underlying idea of this thesis is that many of the roles and the complex interplay of the individual signaling lipids in inflammatory processes and related conditions in health and disease is…

This Thesis describes the design, synthesis and evaluation as glycoprocessing enzyme inhibitors of focused libraries of iminosugars.

Atopic eczema is a skin disease with increasing incidence currently affecting 25% of the paediatric population. In atopic eczema the skin barrier function is reduced. This barrier is formed by the outermost layer of the skin called the stratum corneum (SC). The SC consists of terminally differentiated…

Promotor: M.A.G.J. Orrit

There is a need for alternative methods to replace, reduce and refine (3R) animal experimentation. Combining experimental data from high-throughput in vitro studies with in silico modeling is a promising approach to unravel the effect of chemicals on living cells and to gain a better understanding of…

Many biological processes occur by biomolecules coming together and organizing into specific clusters without being bound to each other. These interactions range from clustering, transiently interacting (kiss and run), or assembling to multimeric units that can only function in conjunction. The hydrogen…

Promotores: Prof.dr. G.F.A Kersten, Prof dr. J.A. Bouwstra

Narrative Science examines the use of narrative in scientific research over the last two centuries.

During adolescence, mood disorder onset peaks. Mood variability is associated with negative mental health outcomes, so understanding biological factors that might be associated with mood variability, such as sleep and structural brain development, could elucidate the mechanisms underlying mood and anxiety…

Promotor: Prof.dr. E.J.J. Groenen

We are a community of researchers from diverse backgrounds who explore becoming and being human, in relation to the world around us and other living beings.

This multidisciplinary minor addresses the fascinating question how we, modern humans, got to be the way we are. Who were our ancestors? How does our morphology, genetic makeup, brain and behaviour relate to that of other species? How does our evolutionary past affect our susceptibility to diseases?…

When you stretch an elastic band, it gets longer. But imagine a material that actually becomes shorter when you pull on it. Sounds strange, doesn’t it? Yet that’s exactly what physicists from Leiden University, AMOLF, and ARCNL have managed to create.

LUCDH is creating a community of LU scholars researching in Digital Humanities. A selection of their DH Projects are listed on this page. If you are an Affiliated member and would like your project listed here or would like to be an Affiliated member, please email us at lucdh@hum.leidenuniv.nl

The 21st century is witnessing a revolution in our understanding of rational points on surfaces and higher-dimensional varieties, and it is in this field that this project lies.

The more complex the object, the harder it is to fold up. Space satellites often need many small motors to fold up an instrument, and people have difficulty simply folding up a roadmap. Physicists from Leiden and Amsterdam have now designed a structure that folds itself up in several steps. Publication…

Water droplets float in a hot pan because of the so-called Leidenfrost effect. Now physicists have discovered a variation: the Elastic Leidenfrost effect. It explains why hydrogel balls jump around on a hot plate making high pitched sounds. Publication in Nature Physics on July 24.

Our faculty has a rich history. Last year, in honour of Leiden Law School’s 450th anniversary, a timeline describing our history in 12 key moments was officially unveiled in the Faculty Room at the Academy Building

On this page you can find information about previous CCLS events.

Conference

The work in this thesis has been focused on two subjects. The first is the assembly of alginate oligosaccharides and the generation of building blocks for the enzymatic synthesis of alginate, and the second is the total synthesis of large fragments of the zwitterionic SP1 polysaccharide.

Jewish Professor Eduard Meijers (1880-1954), along with 29 other Jewish members of staff, was dismissed by the Nazis in November 1940.

The primary goal of this research is to deepen our understanding of substrate-enzyme interactions in Glycoside hydrolases. For this purpose, Bacillus circulans xylanase (BcX) has been selected as a well-established model to examine the Michaelis complex and glycosyl-enzyme adduct.

Carbohydrates are present on the surface of bacteria making them suitable antigen candidates for vaccine development. This thesis deals with the synthesis of two carbohydrate-based components; the capsular polisaccharide of S. aureus type 5 and teichoic acids from staphilococci and enterococci speci…

The Labour Law and Social Security department provides both bachelor’s level and master’s level teaching.

Find out how to apply for French Literature and Culture at Leiden University by following our step-by step guide.

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