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2,129 search results for “shared cell differentiatie” in the Public website

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  Kelly Rosman Coordinator HR Administration

  Administrative Shared Service Centre

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  Koen Evelo Coordinator Servicedesk

  Administrative Shared Service Centre

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  Navdeep Kaur Staff member Servicedesk Finance

  Administrative Shared Service Centre

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  Patricia Scholten Office Manager

  ISSC

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  Nelly Tezbasaran Application Manager (BI)

  ISSC

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  Henry Basselier Coordinator Supply Chain

  ISSC

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  Mansja Sengers Functional Application Manager Workspace

  ISSC

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  Coen Glasbergen Director

  ISSC

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  Toon Hermeler Coordinator Workplace support

  ISSC

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  Coen Venema Linux engineer

  ISSC

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  Teun Kleingeld Functional Application Manager Workspace

  ISSC

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  Narada Sluisdom Staff member HR Administration

  Administrative Shared Service Centre

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  Rebecca Verdoes Junior HR Advisor

  Faculty of Law

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  Barbara Lindemann Staff member Servicedesk Finance

  Administrative Shared Service Centre

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  Michelle Blancke IT Recruiter ISSC

  ISSC

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  Shivani Sohanpal Interim coordinator HR administration

  Administrative Shared Service Centre

• Immunity, Infection and Tolerance Research Dossier

  Our immune system protects us against disease, but every now and then, something goes wrong: an enemy invades our bodies or our immune system attacks our own cells and we become ill. Doctors and researchers at the Leiden University Medical Center (LUMC) want to be able to manipulate the immune system…

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  Lychinta Zichem Senior Adviser Planning & Control

  Faculty of Archaeology

• Development of novel anti-cancer strategies utilizing the zebrafish xenograft model Research output

  In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…

• Physics implications of shape on biological function Research output

  Shape and biological function are tightly connected. Physical descriptions are used to connect the shape of a biological system with its function.

• Therapeutic intervention to enhance atherosclerotic plaque stability Research project

  Proteases degrade matrix molecules in the atherosclerotic plaque, thereby reducing atherosclerotic plaque stability. Mast cells, that contain proteases such as tryptase and chymase, have been identified at the site of rupture in specimens of human coronary arteries and their number in the plaque was…

• A₃ adenosine receptor allosteric modulator induces an anti-inflammatory effect: in vivo studies and molecular mechanism of action Research output

  Source: Mediators Inflamm (2014)

• Mechanical and genetics basis of cellularization and serosal window closure in Tribolium castaneum Research output

  The applications of studying the early development of insects range from agriculture to material science.

• Composition and function of integrin adhesions Research output

  Integrins play an essential role in multicellular life by connecting cells to the extracellular matrix.

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  Herman Spaink Professor of Molecular cell biology

  Faculty of Science

• Cancer pathogenesis and therapy Research Dossier

  With cancer, a person’s body cells grow uncontrollably. Putting together a detailed picture of how this comes about makes it possible to develop efficient therapies. Researchers at the Leiden University Medical Centre (LUMC) and Leiden University are working together to gain a better understanding…

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  Christoph Niessen Guest

• Health research and expertise at the IBL Institute of Biology Leiden (IBL)

  We investigate the molecular basis underlying health and disease and provide answers to existing and emerging health problems. Within this theme, we study diseases ranging from rare genetic disorders to cancer and infectious diseases. We make use of a wide variety of model systems and pursue diverse…

• A tail with a twist: how the tokay gecko grows a completely new body part News - 13 December 2024

  When the tokay gecko loses its tail, a new one grows from resident stem cells at the stump. Each tissue type - muscle, bone, blood vessels and skin - develops from specific stem cells. This discovery by Luthfi Nurhidayat holds potential implications for advancing regenerative medicine in humans. Nurhidayat…

• Ultrasensitive in situ visualization of active glucocerebrosidase molecules Research output

  Deficiency of glucocerebrosidase (GBA) underlies Gaucher disease, a common lysosomal storage disorder. Carriership for Gaucher disease has recently been identified as major risk for parkinsonism. Presently, no method exists to visualize active GBA molecules in situ. We here report the design, synthesis…

• Discovery of metastasis promoting candidate drug targets Research project

  Discovery of metastasis promoting candidate drug targets

• Software Research facility

  Image-Pro Plus, ImageJ, Cell Profiler, R, Knime and NIS-elements

• Computational Biology Research project

  Projects within the theme ‘Computational Biology’ aim to employ mathematical or computational dynamical modelling approaches to discover novel concepts that are important for drug development.

• High throughput microscopy of mechanism-based reporters in druginduced liver injury Research output

  Promotor: B. van de Water

• Exploitation of host chemokine signalling by pathogenic mycobacteria Research output

  Promotores: A.H. Meijer, H.P. Spaink

• A chemical biology approach for targeting of ligand-drug conjugates Research output

  Promotores: Prof.dr. H. S. Overkleeft, Prof.dr. G. A. van der Marel

• Resetting the immune system to cure diabetes and rheumatism Research Dossier: Immunity, Infection and Tolerance

  In autoimmune diseases such as rheumatism and diabetes the immune system attacks autologous proteins. Leiden researchers are trying to discover how this comes about.

• Tail Regeneration in the Tokay Gecko (Gekko gecko) Research output

  Regeneration is the ability of an organism to restore damaged or lost tissue with a functional replacement, and without scarring. Many lizards can regenerate their tails.

• Growth-induced self-organization in bacterial colonies Research output

  Mechanical forces are known to play an important role in bacterial colonies. In this dissertation, we study the self-organization at various stages of growing bacterial colonies, and focus on the mechanical effects of cell growth.

• Sensing Transport Research output

  Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.

• Modelling metastatic melanoma in zebrafish Research output

  Death in all types of melanomas is generally caused by metastasis. Uveal melanoma (UM) is the most common intraocular melanoma, there are currently no (patient-derived) animal models that faithfully recapitulate metastatic dissemination of UM.

• Research Facilities Cell Systems and Drug Safety

  Our Division has created and maintains the Visualisation Core Facilities of the LACDR. This is a multi-user facility offering basic and advanced microscopic techniques to scientists of the LACDR.

• Evaluation of synergistic effects of Chinese herbal medicine and natural compounds on cancers Research project

  What are the biological effects of Chinese herbal medicine in regulation of cancer cell metastasis?

• Mathematical modelling of adverse outcome pathways Research project

  In this project, we aim to develop mathematical models to mechanistically and quantitatively predict the dynamics of cellular stress pathway activation and its relation with toxic effects when cells are exposed to various toxicants.

• New imaging technology to assess early drug success Leiden Early Drug Discovery & Development

  Human and animal cells are very complex: very different chemical processes are going on at the same time, but they are separated from each other because the cells are divided in compartments. These compartments may also have a profound effect on the potential efficacy of therapeutics, because the drug…

• Personalized Medicine Research project

  Getting personal

• About the program Regenerative medicine: curing patients by regenerating organs, tissue and cells

  In 2020, Leiden University launched its stimulated interdisciplinary programs, including one focused on regenerative medicine.

• Flow and Vasculature in Organ-on-a-Chip systems Research output

  Drug development critically depends on preclinical models that mimic human physiology, yet traditional two-dimensional cultures and animal models often lack predictive power.

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  Cecile Herbermann Project-based technician

  Faculty of Science

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  Nina Schulten Research analyst

  Faculty of Science