The loss of T-cell homeostasis and tolerance towards self-antigens is the underlying cause of autoimmune and inflammatory diseases like atherosclerosis, rheumatoid arthritis or type I diabetes. Traditionally, the treatment of these diseases consisted on systemic immune suppression, which can entail…

Few researchers see potential in research on glioblastoma, an incurable brain tumour. Alexander Kros brought together colleagues who are up to the challenge. European research funder ERC recently made 10.6 million euros available, a year earlier NWO provided 3 million euros. ‘In six years, we certainly…

In eight chapters, the thesis of Rafaël Vos covers the effect of temperature and pressure on the electrochemical CO2 reduction.

Promotors: Prof.dr. E. Bouwman, Prof.dr. E. Drent

This dissertation was to develop effective graphene-based nanofluidic devices by developing scalable fabrication methods and elucidating proton transport mechanisms.

The dissociative chemisorption of methane on metal surfaces is of fundamental and practical interest, being a rate-limiting step in the steam reforming process. The reaction is best modeled with quantum dynamics calculations, but these are currently not guaranteed to produce accurate results because…

This thesis focuses on the application of lipid-based nanomedicine in drug delivery, including small molecular antitumor drugs and biomacromolecules including mRNA, and evaluates their biological performance.

Viral diseases constitute one of the major challenges in modern medicine. Membrane-targeting have broad-spectrum potential and could distinguish viral membranes from the host cell plasma membrane by the difference in membrane curvature.

This thesis describes the development of a variety of mannosylated conjugates. Antigen presenting cells bear mannoside recognizing receptors that actively transport antigen into the cell. This thesis exploits this feature for the development of improved vaccines.

The adsorption of D2 and CO2 on catalyst surfaces is studied using a molecular beam in ultra-high vacuum.

To be eligible for Chemistry at Leiden University, you must meet the following admission requirements.

The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.

Former Leiden Observatory PhD candidate Danna Qasim has won no less than two prestigious prizes with her thesis, titled 'Dark ice chemistry in interstellar clouds'. Qasim received the IAU PhD Prize from the IAU. The Astrochemistry Subdivision of the American Chemical Society (ACS) honoured her work…

Leiden researchers Arko Ghosh and Enea Ceolini analysed the usage data of hundreds of mobile phones and discovered that our body has rhythms ranging between 7 and 52 days. These cycles influence how we behave. Their research resulted in an article in npj Digital Medicine journal, a Nature Portfolio…

Huiselijk geweld is een ingrijpend probleem in Nederland, met jaarlijkse fatale gevolgen. De impact gaat verder dan alleen de slachtoffers zelf en raakt ook nabestaanden en de samenleving als geheel. Tot nu toe/Momenteel ontbreekt het echter aan een gestructureerde manier om fatale gevallen systematisch…

Contact Supramolecular & Biomaterials Chemistry

Promotor: M.T.M. Koper, Co-Promotor: L.B.F. Juurlink

Theorists have recently made substantial progress in simulating reactive molecule-metal surface scattering but still face major challenges. The grand challenge is to develop an approach that enables accurate predictive calculations of reactions involving electronically excited states with potential…

The probability for dissociation of molecules on metal surfaces, which often controls the rate of industrially important catalytic processes, can depend strongly on how energy is partitioned in the incident molecule. There are many example systems where the addition of vibrational energy promotes reaction…

In this thesis, the researcher developed a nanosystem based on the metallophilic Interaction between cyclometalated complexes.

M.T.M. Koper, Co-promotor: D.G.H. Hetterscheid

Contact Theoretical Chemistry

Promotor: E. Bouwman Co-Promotor: S. Bonnet

An accurate description of reactive scattering of molecules on metal surfaces often requires the modeling of energy transfer between the molecule and the surface phonons. Although ab initio molecular dynamics (AIMD) can describe this energy transfer, AIMD is at present untractable for reactions with…

Photocatalysis has emerged as a powerful tool for enabling challenging transformations in organic synthesis. This thesis explores the development of several photocatalytic reactions designed to form carbon-heteroatom bonds from less-functionalized precursors.

The Leiden Institute of Chemistry (LIC) offers a unique tailor-made programme in Chemistry. You can customize the programme to your own interests and ambitions with the help of your own personal mentor. Your study will focus on either Chemical Biology or Energy & Sustainability. During the Master's…

Op donderdag 17 april 2025 neemt prof. dr. Marco Mostert, Hoogleraar Middeleeuwse Geschiedenis aan de Universiteit Utrecht afscheid.

The Leiden Institute of Chemistry organises and participates in several programmes for high school students and teachers.

Synthetic hydrogels that mimic the natural extracellular matrix in the biophysical and biochemical cues it provides to cells are in high demand, however the cell phenotypes as they are observed in vivo in numerous cases have yet to be attained.

The chemical industry must continue to innovate for a more sustainable, healthier society. The reseachers from the Leiden Institute of Chemistry (LIC) contribute by applying their knowledge to themes such as sustainability, energy and health.

Coordination chemistry is the chemistry of metal atoms

Molecular Physiology is a research group at the Leiden Institute of Chemistry dedicated to the design, synthesis and application of chemical tools to study important biological and biomedical questions. The group is headed by Prof. Dr. Mario van der Stelt and includes the research lines of Assistant…

The master’s specialisation Bio-Pharmaceutical Sciences and Education at Leiden University combines fundamental chemistry research with an excellent education in becoming a Chemistry teacher.

Promotor: J.G.E.M. Fraaije, Co-Promotor: A. Kros

The role of the interfacial environment during electrochemical reactions has been increasingly valued, especially for those reactions involving protons or hydroxyl ions.

Promotor: G.A. van der Marel, Co-promotor: D.C. Codée

Curved single crystals provide variable, but well-defined surface structures.

Promoter: J.G.E.M.Fraaije, Co-promotor: A. Kros

This thesis systematically analyzes the physical-chemistry of lipid-graphene interactions with the major objective of reconciliating the variety of results reported in the literature.

Overkleeft

Promotor: A. Kros

Single-layer graphene (SLG) has attracted considerable interest as a proton exchange membrane for direct methanol fuel cells (DMFCs), owing to its atomic thickness, mechanical robustness, and unique proton permeability.

This 1.0 version of FitDis! is an archive containing the tool, a quick manual and a test dataset. The FitDis_M.zip package contains the sourcecode Matlab M-files.

Do you have a question about studying at Leiden University or student life in Leiden? Do you want more information about the Chemistry programme? Chat with a current student for answers to your questions!

Oncode Investigator Mario van der Stelt and his colleagues have discovered a new potential drug that suppresses chemotherapy induced neuropathic pain.

In this thesis we have discussed several parameters that affect the electrochemical conversion of enviromentaly harmful molecules such as nitrates and carbon dioxide to more valuable and less deleterious compounds, in order to cast light onto the mechanism of the reaction to achieve an efficient and…

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: J.D.C. Codee

This dissertation contains four works during my PhD. Different biomaterials have been designed based on coiled-coil peptides. These biomaterials have a range of applications, inclusing drug delivery, cell sorting to cell-cell fusion.

A new type of tripodal squaramide-based supramolecular hydrogels is developed and studied.

This doctoral thesis is an effort to understand how lipid phase-separation induced by diacylglycerol analogues in lipid-based nanoparticles affects their in vivo behavior, leading to specific nanoparticle-protein communications and selective cell targeting.