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This study proposes a theory for the encoding of specificity and definiteness in the Chinese nominal based on Cantonese, Mandarin and Wenzhou data.

A structural investigation of coiled coil peptides used as membrane fusogens, mimicing naturally occuring coiled-coil fusion proteins. Synthetic modifications have been made to alter lipid attachment, secondary structure and to insert photoactive azobenzene moieties for active control over coiled coil…

In the master’s specialisation Molecular Genetics and Biotechnology at Leiden University students are trained by experts in the areas of molecular biology, microbiology, plant genetics, cellular imaging, animal disease models, and various –omics technologies and the corresponding bioinformatics.

Promotor: Prof.dr. T. Schmidt, Co-Promotor: Dr. ir. S.J.T. van Noort

Investigating neurobiological endophenotypes of Social Anxiety Disorder

PhD defence

Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.

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Are traces of fire use detectable in ancient hominin genomes?

This study analyses the prehistory of a northeastern Siberian population, the Sakha, from both a molecular-genetic and a linguistic perspective.

How does invasive hybridization affect threatened native species?

A collaboration between the IBL and LUMC has resulted in the discovery that the polymerase theta enzyme is essential for the integration of Agrobacterium T-DNA into the genome of plants. The finding means a break-through for the development of more efficient systems for targeted genome modification…

Promotor: Prof.dr. G.R. de Snoo

How do genetic and environmental factors make us vulnerable to depression?

Promotor: P.M. Brakefield

Which adolescents are more at risk of developing social anxiety disorder later in life?

Description of Triple bottom line approach for risk-benefit analysis of genetically modified crops.

DNA carries various forms of information. Out of these forms of information the most well-known is classical genetic information.

The four possible segments A, T, C and G that link together to form DNA molecules, and with their ordering encode genetic information, are not only different in name, but also in their physical and chemical properties.

The applications of studying the early development of insects range from agriculture to material science.

This dissertation and the corresponding films and recordings presented here are an effort to distil an approach to performing the orchestral music of Johannes Brahms that is significantly different from what has hitherto been produced in the fields of both Mainstream Orchestral Performance Practice…

In this project, we will study the genetic and environmental drivers of woodiness and stem lignification at the level of plant‐to‐gene‐to‐molecule.

Fungal food spoilage often starts with a contamination with spores. Experimental data strongly indicate the existence of subpopulations of spores with different levels of resistance to preservation methods.

Freshwater is an important resource, but at a great risk of species decline due to habitat loss, pollution and over-exploitation, and invasive alien species.

Starting from Husserl’s somewhat controversial claim about the immortality of the constituting subjectivity, this thesis uses the limit-case of death in order to present a phenomenological exploration of the notion of subjectivity and its relationship to nature. It also offers a second-order discussion…

Chemical tools to monitor drug-target engagement of endogenously expressed protein kinases are highly desirable for preclinical target validation in drug discovery. Here, we describe a chemical genetics strategy to selectively study target engagement of endogenous kinases.

Are there elements of the lost performance practice of the nineteenth century that we can rediscover and use to shed new light on the performance of Brahms’ music for orchestra today?

The main aim of this research is to understand the dynamics of identity within indigenous Caribbean communities as expressed through the practice of intentional cranial modification. A multidisciplinary approach will be applied to achieve this aim, combining current anthropological and sociological…

What is the population size/structure and distribution of tiger and leopard inside the Bardia National Park (BNP) compared with the population outside? What is the movement and home range and conflict pattern in time and space of tigers and leopards inside the BNP compared with outside? What constitutes…

The mission of the Plant Science research programme is to contribute to the sustainable production of high quality crops, flowers and high-value bio-based products. This is realised by generating fundamental knowledge of basic biological processes related to development of plants and their interaction…

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Human measures to protect lions have an impact on the genetic health of populations. Leiden and Kenyan scientists discovered this by analysing the DNA of 171 Kenyan lions. ‘By fencing reserves, for example, the chance of inbreeding increases.’ With the knowledge and tools from the research, management…

In an innovative study, Radboudumc and LUMC jointly tested a candidate vaccine based on a genetically weakened malaria parasite. The results of this clinical trial, published in Science Translational Medicine, show that the vaccine is safe and elicits a defense response against a malaria infection.

Supervisor: P.J.J. Hooykaas Co-Supervisor: R. Offringa

It was already known that social anxiety disorder often affects more than one person in the same family. But research by PhD student Janna Marie Bas-Hoogendam has now shown that there are genetic brain characteristics that are associated with social anxiety. The PhD ceremony will take place on 14 Ja…

How is Pol θ responsible for T-DNA integration, and how do other DNA double-strand break repair pathways interact with Pol θ? How may we manipulate T-DNA integration to stimulate error-free integration at a predetermined genomic site?

This report investigates the different approaches in the authorization process of GMOs for commercial use in the European Union and the United States of America. Three main aspects are considered and analyzed as potential causes of differences in the authorization process of GMOs for commercial use.…

This thesis describes the genetic and prokaryotic diversity of giant barrel sponges.

The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.