Whether a microbe is beneficial or harmful to a plant can now be predicted with high accuracy thanks to bacLIFE. This bioinformatic tool with an intuitive interface makes it much easier to unlock the secrets of bacterial genomes. A group of Leiden biologists presented it in Nature Communications.

The guardian of our genome, the protein MutS, scans the DNA for spelling errors and makes sure they are corrected. An essential process for our health. Researchers at Leiden University Medical Centre (LUMC) have discovered precisely how this protein works by making MutS visible with cryo-electron microscopy.…

Inaugural lecture

In november 2023 is Anne Fleur van Veenstra, wetenschappelijk directeur van TNO Vector, benoemd tot bijzonder hoogleraar ‘Governance van data en algoritmen voor stedelijk beleid’.

Sustainable biotechnology, new insights into genome evolution and combining forces in mathematics. The NWO has awarded grants to these three innovative Leiden research projects in the ENW-M Open Competition.

PhD defence

PhD defence

Early diagnosis, new treatments, and personalised care: all of these are possible if we can better unlock the wealth of information hidden in health data. Unfortunately, this data is often poorly organised, difficult to access, and not interoperable. The new international Leiden Institute for FAIR and…

Collaborating and learning from other fields – that is what bioinformatician Hannah Augustijn enjoys most about doing research. During her PhD at Leiden University, she developed new ways to search within bacteria for the antibiotics of the future.

In de maanden maart, april en mei organiseerde het programma Transparantie in Informatie, van de ministeries van Economische Zaken en Klimaat (EZK) en Landbouw, Natuur en Voedselkwaliteit (LNV), gesprekken over de veranderopgave naar een Open Departement. De sessies hadden als doel om een eerlijk en…

For the second year in a row, LACDR organized an international symposium on molecular fold topology. An afternoon program centered around the theme “circuit topology”, inspired and connected mathematicians, physicists and chemists. Scientists from USA, Europe, and Asia participated in this online ev…

Good research means looking beyond disciplinary boundaries, said Professor of Molecular and Cellular Biochemistry Remus Dame in his inaugural lecture on 10 May. Processes that take place on DNA shouldn’t only be researched in a test tube but also in living cells, for instance.

Assistant Professor Karlsson Linnér, who works at the Department of Economics, is one of the recipients of a Veni grant. His research on the accuracy of preventive genetic testing is a fine example of the intersection of economic science and law.

This month, the first part of the quality assurance audit (ITK) took place. A team of auditors from the Nederlands-Vlaamse Accreditatie Organisatie (NVAO) visited us to review how we ensure quality in education and how this aligns with our overall vision.

Paco Barona Gomez is the newest associate professor at the Institute of Biology Leiden (IBL). The Mexican researcher is fascinated by the evolution of natural products: compounds made by microbes, but also plants and animals. ‘It’s like we investigate chemical dark matter.’

Some bacteria, it turns out, have proteins much like ours that organise the DNA in their cells. They just do it a bit differently. This is revealed by new research from biochemists at the Leiden Institute of Chemistry and the Max Planck Institute for Biology. The discovery helps us better understand…

On the 8th of December 2021, Leiden Academic Centre for Drug Research (LACDR) organized “Circuit Topology 2021”, the first international symposium on circuit topology. The focus was on the mathematical notion of Circuit Topology, and its applications to physics, chemistry and biomedicine.

Identifying novel antibiotic compounds to tackle antibiotic-resistant bacteria. Researchers from Leiden University and VU Amsterdam will unite through a project now funded by NWO’s Open Technology Programme (OTP), which awarded the collaboration nearly one million euros.

For the third consecutive year, LACDR organized the international symposium on topology, Circuit Topology III, on November 29, 2023. The event aimed to bring together experts from diverse fields, including mathematics, computer science, physics, chemistry, and biomedical sciences, to discuss cutting-edge…

Sebastian Pomplun receives an ERC starting grant of 1.85 million Euros in five years. He wants to develop synthetic transcription factors that can enter cells and activate or deactivate specific genes. For example to disrupt cancer-related processes or to trigger the production of an important missing…

Transferring poo from healthy donors to the intestines of chronically ill people has beneficial effects on these recipients’ gut bacteria, also in the longer term. This is the conclusion of research by the Leiden University Medical Center (LUMC) and the Netherlands Donor Feces Bank (NDFB).

Conference

Debate, Seminar

PhD defence

To facilitate the search for new antibiotics. That is the aim of Gilles van Wezel, professor molecular biotechnology at the Institute of Biology Leiden (IBL). He wants to do this by looking at similarities in the DNA of antibiotic-producing bacteria. Van Wezel has been awarded an ERC Advanced grant…

Researchers from the Leiden University Medical Center (LUMC) have successfully used stem cell gene therapy to treat a baby with the severe congenital immune disorder SCID. An important milestone: it is the first time stem cell gene therapy of Dutch origin has been administered to a patient, and also…

What started as an idea during a social gathering led to an unexpected breakthrough in research on resistant bacteria. Biologists and chemists from Leiden developed a new substance that proves to be effective against bacteria resistant to antibiotics. They published their discovery in Nature Chemist…

How do animals choose their partners? The answer is simple: it’s all about quality. While humans tend to wear clothes that happen to be in fashion, animals do nothing without a reason. Behind beautiful plumage or a deafening roar is only one message: I am in great shape. The evolutionary courtship displays…

During illness, the stiffness or viscosity of cells can change. Tom Evers demonstrated this by measuring such properties of human immune cells for the first time. ‘The stiffness of certain cells could be a way to make a diagnosis,’ Evers said. He defended his thesis on March 26th.

No fewer than 55 applications were submitted for a Kiem seed grant, an initiative for developing new interdisciplinary, interfaculty research partnerships and encounters. The draw took place on Monday for the allocation of 22 seed grants. The Executive Board was so impressed with the number of applications…

How can we view societal challenges from a different perspective? At the EuroScience Open Forum (ESOF), Robert Zwijnenberg, Emeritus Professor of Art and Science Interactions, will call for more collaboration between artists and scientists.

In July, Leiden will be hosting the EuroScience Open Forum conference. Humanities scholars from Leiden will make use of the opportunity to stress the importance of art in science. ‘Artists have the ability to show the consequences of science.’

Rapid developments in DNA techniques allow researchers to find out more and more about human genetics. An international group of scientists has drawn up five ethical guidelines to ensure that this DNA research is better regulated. Leiden archaeologist Marie Soressi – one of the signatories - explains…

Festival

Lecture