The Life in Custody (LIC) Study comprises a large-scale research project into prison climate and the quality of prison life in Dutch prisons.

New Chinese CSC PhD’s are welcomed at the Leiden Institute of Chemistry. On the 28th of September 2012 a three week introduction program started especially for this new incoming group of scientists.

Starting 1 August Lies Bouwman has been appointed as Director of Education at the LIC. She will combine this role with her position as the Programme Director of the Master's programmes in Life Science and Technology (LST) and Chemistry. By doing so, she joins the new collegial institute board of the…

As of July 1, Professor of Bio-organic Synthesis Hermen Overkleeft will be appointed as the Scientific Director of the Leiden Institute of Chemistry (LIC). He will succeed Jaap Brouwer, who has been managing the institute for the past twelve years. Overkleeft has been appointed for a period of four…

As of 1 July, Marcellus Ubbink is the new Scientific Director of the Leiden Institute for Chemistry. He will succeed Hermen Overkleeft, who led the institute since 2017. Ubbink has been appointed for a period of four years.

Lecture

Discover the outstanding researchers and educators recognised by our faculty. This page gives an overview of all prize winners.

We would like to invite you to a new seminar series that aims to bring together all researchers in Leiden that are interested in biophysics and structural biology. L(SB)2, the Leiden Seminars in Biophysics and Structural Biology, takes place monthly and combines presentations of talented PhD students…

On this page you can learn more about the history of our Faculty Awards and view the previous winners.

Contact information & address

An overview of awards and prizes granted to our staff and students in 2018, as well as special appointments and royal distinctions.

An overview of awards and prizes granted to our staff and students in 2019, as well as special appointments and royal distinctions.

Contact Medical Biochemistry

This is an Erasmus+ International Credit Mobility project of the Faculty of Science with the Taras Shevchenko National University of Kyiv.

Are you a PhD or postdoc at the Leiden Institute of Chemistry? Join our community to amplify your voice, grow professionally, and build lasting connections within our institute.

An overview of awards and prizes granted to our staff and students in 2020, as well as special appointments at Leiden University and other institutions.

The Leiden Institute of Chemistry (LIC) is the basis for research and collaborations of the Leiden chemistry groups. Chemistry is the central science enabling a healthy future in a sustainable society. Chemistry researchers at Leiden University take a fundamental approach in finding tailored solutions…

An overview of awards and prizes granted to our staff and students in 2021, as well as special appointments at Leiden University and other institutions.

The chemical industry must continue to innovate for a more sustainable, healthier society. The reseachers from the Leiden Institute of Chemistry (LIC) contribute by applying their knowledge to themes such as sustainability, energy and health.

Education & outreach

In CCLS several subgroups have formed, below you can find an overview of these groups with the names of the leading researchers and a short outline of the project.

Conference

This 1.0 version of FitDis! is an archive containing the tool, a quick manual and a test dataset. The FitDis_M.zip package contains the sourcecode Matlab M-files.

The drug BIA 10-2474 inhibits fatty acid amide hydrolase (FAAH), a lipase that degrades a specific endocannabinoid. On the basis of this activity, BIA 10-2474 was being developed as a potential treatment for anxiety and pain. In a phase 1 trial of the drug, one subject died, and four others suffered…

A high-end label: Cyclophellitol aziridine-type activity-based probes allow for ultra-sensitive visualization of mammalian β-glucosidases (GBA1, GBA2, GBA3, and LPH) as well as several non-mammalian β-glucosidases (see picture). These probes offer new ways to study β-exoglucosidases, and configurational…

Three at the same time: a ligation strategy combining tetrazine–norbornene cycloaddition, Staudinger–Bertozzi ligation, and copper(I)-catalyzed click reaction was used to label the three catalytic activities of the proteasome simultaneously in a single experiment. The orthogonality of the three ligation…

On this page you will find an overview of awards and prizes granted to our staff and students in 2025, as well as special appointments at Leiden University and other institutions.

The Leiden Institute of Chemistry (LIC) offers a unique tailor-made programme in Chemistry. You can customize the programme to your own interests and ambitions with the help of your own personal mentor. Your study will focus on either Chemical Biology or Energy & Sustainability. During the Master's…

LED3 is the combined effort of three excellent institutes of Leiden University. Through joined hands, we are able to give rise to a more effective early drug discovery pipeline. Let us briefly introduce the three institutes.

The thesis describes the development, synthesis and biological evaluation of several proteasome inhibitor designs. Mainly, this work focusses on designing proteasome inhibitors that selectively inhibit the immunoproteasome, while leaving the constitutive proteasome mostly, if not completely, untouch…

In this thesis the combinatorial use of bioorthogonal labelling and Electron Microscopy (EM)-based imaging techniques is explored to enable observations of specific molecular targets in their ultrastructural context within the cell.

This thesis has shed light on some of the ways in which the local electrolyte composition can differ from the bulk and how these changes in the local reaction environment can determine the activity and/or selectivity of two important electrocatalytic reactions, namely, electrochemical CO2 reduction…

This thesis describes the design and synthesis of novel small molecules based on sulfur-containing heterocycles for the inhibition of glycosidases and glycosyltransferases related to Fabry and Pompe disease.

The cannabinoid receptor type 2 (CB2R) is associated with several inflammatory diseases with an unmet medical need (e.g. Alzheimers, multiple sclerosis, reumatoid arthritis). Development of new chemical biology strategies to study this protein is essential to aid future development of drugs for these…

A deceptively simple, complicated paper

Het proefschrift omschrijft de chemische synthese van fenolische glycolipiden van verschillende mycobacteriën met het doel om deze te kunnen gebruiken voor immunologisch onderzoek.

Several techniques are explored for going beyond the born-oppenheimer static surface model for molecule-surface reactions.

Design and synthesis of two 3-substituted swainsonine derivatives with the aim to improve the potency and selectivity towards Golgi alpha-mannosidase II.

The loss of T-cell homeostasis and tolerance towards self-antigens is the underlying cause of autoimmune and inflammatory diseases like atherosclerosis, rheumatoid arthritis or type I diabetes. Traditionally, the treatment of these diseases consisted on systemic immune suppression, which can entail…

Hass

Synthetic methodlogy is described, aiding in the synthetic preparation of putative inhibitors of retaining and inverting glycosidases and glycosyl transferases. All constructs are cyclophellitol-based cyclitols.

The chemical synthesis of inhibitors and probes targeting endo-glycosidases.

The aim of the research described in this thesis was to use structure-based design to optimise multiple properties of aryl sulfoxide monoacylglycerol lipase inhibitors as anti-inflammatory analgesics.

Thesis focused on uncovering the underlying mechanisms of the lysosomal storage disorders Gaucher's disease using chemical tools, biochemical assays and lipidomics.

Do you have any questions about the Chemistry master’s programme? Please contact us!

Do you have any questions about the Life Science and Technology master's programme? Please contact us.

This thesis focuses on the application of lipid-based nanomedicine in drug delivery, including small molecular antitumor drugs and biomacromolecules including mRNA, and evaluates their biological performance.

Now online in Molecular Microbiology our studies on the motility of Sulfolobus acidocaldarius and its unique swimming organelle, the archaellum.

This Thesis describes the synthesis of D-alanylated ribitol-based wall teichoic acids from S. aureus to probe their interaction with immune-binding partners.