Dying from viral infection due to organ failure and blood loss: we still know little about how it can happen. Among other things, Huaqi Tang developed an organ-on-a-chip to figure it out. 'These technologies can offer unprecedented opportunities to fight the viruses that threaten our society.' Tang…

Viral hemorrhagic fever (VHF) is a group of acute diseases caused by highly infectious viruses including Ebola, Lassa, Dengue viruses. Its high mortality rate poses high risk to public health, however, studies on VHF have been hampered due to the non-availability of proper models and incomplete knowledge…

Cytotoxic T-cells (CTLs) are involved in the clearance of viruses and killing of tumor cells.

Research in the Daniela Kraft Lab focuses on self-assembly in biological and soft matter systems, ranging from anisotropic colloidal particles to lipid membranes, emulsions, and viruses.

The outbreaks of AIDS and COVID-19 showed clearly how infectious viruses can influence people’s lives. Investigating the changes in the host metabolism may provide a paradigm shift to consider immune-metabolic interactions as therapeutic targets.

We aim to develop a microfluidic platform that can parallelize testing the performance and characteristics of pure, mixed and environmental bacteriophage samples.

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The ambition of the Medical Systems Biophysics and Bioengineering group led by Alireza Mashaghi is to develop and use physics and engineering concepts and tools for pathophysiology, diagnostics and therapy.

Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken

Several single-stranded RNA viruses make use of Xrn1-resistant RNAs in their 3’ untranslated regions of their genome RNAs in order to increase their pathogenicity.

Promotoren: G.F.A. Kersten, W. Jiskoot, Co-promotor: J-P. Amorij

How can we manipulate the biotic and abiotic environment to increase thrips resistance in tomato and chrysanthemum? More specifically we ask: How can plant secondary metabolites that are not soluble in water be delivered to plants in seed coating or root dipping treatment? Can bacteria be used to…

A main goal of MSBB research is to address the major bottle-necks in combatting viral diseases: the lack of experimental models that are representative of human pathology and are cost effective and versatile. Viral diseases such as those that cause viral hemorrhagic syndromes or severe acute respiratory…

The CIGR brings together a diverse range of unique expertise in genome research rooted in biology, chemistry and physics. Members of the CIGR investigate genome folding and genome transactions. An important aspect is direct as well as long term relevance for medicine.

The Risk and Regulation Lab from organises events and workshops in Leiden and The Hague. On this page you can read reports of the events that already took place.

During the Leiden Science Family Day, you will visit places that are normally closed to the public: go backstage at the Faculty of Science!

Physicists, including Leiden researcher, Sanli Faes, have devised a new technique for studying processes at microscale rapidly and extremely precisely. This new method will make it easier to develop antiviral medication. And it doesn’t stop there. Publication in ACS Nano.

Epithelial cells play a crucial role in the lungs. PhD student Ying Wang researched the effects of cigarette smoke and viruses such as COVID-19 on these epithelial cells. ‘We hope to reduce the risk of pandemics in the future.’

Isotopes on exoplanets, a more efficient memory for data centres or new molecules that work against the Zika virus and HIV. Which PhD candidate has written the most impressive dissertation of 2023? The jury of the C.J. Kok Jury Award faces the challenging task of deciding that. Meet the nominees of…

Leiden has a long history in the treatment of blood cell cancer. Research to find better therapies never stands still. One of the potential treatments currently being worked on is a ‘living medicine’.

We’re susceptible not only to viruses, but also to fear of viruses. What are the psychological principles at work here? Social and organisational psychologist Gert Jan Lelieveld on the Corona virus at the Dutch news website NRC. Read his 'behavior column' in English.

A flu virus could cause a pandemic. And then we would be poorly armed because flu viruses are starting to become resistant to flu medications like Tamiflu. Chemist Merijn Vriends successfully worked on an improved version of such medications. He will be awarded his doctorate on September 12th.

A single tiny molecule that can destroy flu, corona, HIV and Zika viruses? Yes, it really does exist. Biophysicist Niek van Hilten, who will receive his doctorate on 14 September, contributed to this discovery.

Professor of Ultrastructural Biology Ariane Briegel has received a grant in the NWO Open Competition Domain Science in the XS category. This grant emphatically encourages curiosity-driven and bold research with a maximum of 50,000 euros.

Researchers need to work in specialized environments when they work with dangerous bacteria and viruses. These microbes spread easily, so only in labs with a high biosafety levels they can be studied. Unfortunately, to look at the microbes properly, expensive microscopes are needed that are not always…

Ten Leiden researchers have been awarded a Veni grant by the Dutch Research Council (NWO). The grant, of up to 280,000 euros, will enable them to elaborate their ideas over a period of three years.

The genetic code of the new coronavirus has been found: it is closely related to the SARS virus from 2003. Professor of Molecular Virology, Eric Snijder, has been researching coronaviruses for years. We asked him a few questions about the outbreak. ‘It’s still unclear whether this new virus is more…

A team of students from Leiden won the iGEM international biology contest in 2020 with their Rapidemic mobile testing kit. The kit makes it easy to detect viruses. The team has now been nominated for the Most Innovative Student in the Netherlands prize. Cast your vote and help them develop their inv…

Vaccines are an extraordinary category of biopharmaceuticals. They are usually prophylactic and come in many types, from whole bacteria to peptides and nucleic acids. They are very cost effective and almost every human on the planet is vaccinated. The latter mandates that vaccines have to be extremely…

The research group of Eric Snijder, Professor of Molecular Virology (LUMC), has been conducting research on coronaviruses for decades. Then in March this year their work accelerated at an unprecedented rate. The first new results are now available: insight into how the virus replicates.

Infecting each other with viruses and bacteria while protecting yourself with medicines and vaccinations. Sounds like a fun evening, right? Master students Life Science & Technology Rafael Jezior and Dennis de Beeld certainly think so. Together, they developed ImmunoWars: an exciting card game based…

Many dangerous diseases such as COVID-19, Ebola and Q fever have jumped from animals to humans. But it is not only because of these diseases that we should include animals in our health policy, but also because of their right to health, writes PhD candidate Joachim Nieuwland. PhD defence on 13 May.

Bacteria temporarily live without their cell wall if dangerous viruses are near. A remarkable feature, as the cell wall is a sturdy barrier against threats. Still, the discovery has a logical explanation ánd might be of a consequence for fighting pathogenic bacteria, according to Véronique Ongenae,…

Phage therapy is a novel yet unmatured therapeutic approach in the face of the crisis of antimicrobial resistance (AMR). Dr. Tingjie Guo received a grant from the Elise Mathilde Fund and the LUF to develop innovative phage-antibiotic combination treatment strategy for combating AMR.

Our immune system protects us against disease, but every now and then, something goes wrong: an enemy invades our bodies or our immune system attacks our own cells and we become ill. Doctors and researchers at the Leiden University Medical Center (LUMC) want to be able to manipulate the immune system…

The Division of Systems Pharmacology and Pharmacy (SPP) aims to develop precision medicine approaches to characterise and predict variation in treatment response and enhance translational drug development strategies.

The EU proposal for a regulatory framework on artificial intelligence will not prevent the dangers of cybercrime or the spreading of fake news using ChatGPT. Cyber criminals can use the new technology to write harmful software, phishing mails and fake news.

Emeritus Professor Ben Lugtenberg edited a book on “Principles of Plant-Microbe Interactions” together with Paul Hooykaas, Eddy van der Meijden and Jos Raaijmakers, all from the IBL.

Evolution is all around you every day. This is the message of the new Massive Open Online Course (MOOC) of Leiden University and Naturalis that begins on September 19.

Evolution is all around you every day. This is the message of a Massive Open Online Course (MOOC) of Leiden University and Naturalis that is offered free of charge to anyone interested.

Did he dare take a gamble with his PhD research? Jeroen Methorst didn’t have to think long about it. It could fail or turn out very well. The latter is the case. Methorst developed a computer system that helps researchers find the protein they need. ‘Our whole group is now using this program.’ Methorst…

A night sky of more than 40 petabytes in size, simulating young star clusters and understanding how the body inhibits viruses: three Leiden projects have received computing time on one of the national computer systems.

PhD ceremonies in the Academy Building will be much easier for family, friends and other non-specialist audience members to follow after the summer. The Doctorate Board is pleased to have decided that as of 1 September, all Leiden PhD candidates will begin their PhD defence with a lay talk. ‘It can…

The Janssen-Cilag International N.V COVID-19 vaccine has received authorization for emergency use by the European Medicines Agency (EMA) on March 11. The vaccine was developed with fundamental support from the Molecular Virology group of the Leiden University Medical Centre (LUMC).

De crèche en het klaslokaal zijn misschien wel de meest gunstige plekken voor ziekteverwekkers. Toch is er relatief weinig bekend over hoe kinderen reageren op virussen en bacteriën en hoe het komt dat sommige kinderen veel beter beschermd zijn dan anderen. Simon Jochems, onderzoeker aan het Leids Universitair…

Just before Christmas, three talented scientists received good news: they are receiving a personal research grant from the Dutch Heart Foundation. Ilze Bot of the Leiden Academic Centre for Drug Research is one of those scientists. She will receive an Established Investigator grant of 650,000 euros.…

The European PANVIPREP research project started at the Leiden University Medical Center on 11 March. The participants are virologists, biochemists and pharmacists from 14 European countries. Their mission is to develop antiviral drugs to protect Europe during pandemics. At least two such antivirals…

Four university medical centres, including the LUMC, are joining forces to increase pandemic preparedness in the Netherlands.

Four researchers from Leiden University have been awarded prestigious Vici grants the Dutch Research Council (NWO) has announced. The honoured applications are from researchers at the Faculty of Social and Behavioural Sciences, Leiden Observatory, the LUMC and the Faculty of Archaeology.