Lysosomal glycosidases are acid hydrolases that fragment glycoconjugates in lysosomes.

Together with researchers from over the world, the ENIGMA-Anxiety Working Group endeavors to unravel the neurobiology of anxiety disorders and related constructs.

Young children, adolescents and students may experience learning difficulties as a result of lack of sleep. Dr Kristiaan van der Heijden investigates sleep problems and solutions for various age groups.

Health is a wonderful gift, both for humans and for society. If we are able to prevent both physical and mental illnesses, we can spare a lot of suffering and fight rising health costs. Social scientists and physicians in Leiden are working closely together to conduct research on the human mental, behavioural…

-

-

Speech Prosody 2024 includes seven special sessions. When making a submission, authors are asked to indicate whether they want their paper to be considered for a special session. You can find descriptions of each below.

What are the developmental pathways to social anxiety (disorder), the causal processes and maintaining factors? How do these factors interact in the development of social anxiety disorder? How can this knowledge be used to design and implement effective preventive intervention programs for youth?

In this project we followed children of parents with an anxiety disorder. We wanted to examine how these children develop and try to better understand why it is that some children develop fears, whilst other children do not. In this project, we mainly focus on social anxiety disorder and panic disor…

Through metabolism, biochemical processes give rise to the complexity of life. Acquired and inborn errors in metabolism underlie many diseases occurring in man. The challenge for present day medical biochemistry is to find, and integrate, pieces of information at molecular, cell and organismal level…

People already diagnosed with a mental disorder before the COVID-19 pandemic did not show a disproportionate increase in symptoms afterwards. This is one result from the first systematic review of longitudinal studies following their study population from before to during the first eighteen months of…

Clinical psychology is a discipline concerned with the application of psychological science to the assessment and treatment of mental disorders.

The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…

This thesis presents the results of a study on the interfaces of insulating oxides with and without the insertion of a magnetic layer.

The company Azafaros was established in 2018 to translate innovative science from Leiden University and Amsterdam University Medical Center into novel disease-modifying treatment modalities for rare genetic metabolic disorders such as lysosomal storage diseases.

Promotor: A. Doelman, Co-promotor: J.D.M. Rademacher

Developmental and Educational psychology is concerned with the developmental course and dynamics of cognition, self-regulation, and emotional competence, and the implications for educational and clinical practice.

Semiha Aydin is one of the three first-generation researchers who received a grant from the Leiden Empowerment Fund to stimulate their scientific career.

The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.

PhD defence

PhD defence

Can excessive worrying be reduced via stimulation of the vagus nerve?

FSW Professor Jan Dirk Blom has written a book on Alice in Wonderland syndrome. This is the first scientific book on this rare disorder, which was first described in 1955 by the British psychiatrist John Todd. Todd was inspired by the famous book by Lewis Carroll, in which Alice experiences all kinds…

Supervisor: Indira Nederpelt

In this research project, we aimed to obtain more insight in the role of mast cells in the immune driven disorders rheumatoid arthritis and atherosclerosis.

There is greater variety in the size of men’s brains than of women’s. This could help explain why some psychiatric disorders such as ADHD and autism are more prevalent in boys. Leiden brain researcher Lara Wierenga has published an article about this in the international journal Cerebral Cortex.

Undesirable associations with sex can be unlearned, but return if the circumstances change. They must therefore be unlearned in different situations. The drug D-cycloserine may help here. These are the findings of psychologist Mirte Brom.

In what way can new tools and techniques be used to develop drug candidates for the treatment of neurological disorders?

All living creatures have to cope with environmental demands and threats that challenge their physical or emotional homeostasis.

Can zebrafish larvae be used as a behavioural model for screening natural products as potential neurotropic drugs?

At this year's conclusion of the PRE-Class Psychology, the central hall of the Faculty of Social and Behavioural Sciences became a hub of knowledge exchange revolving around a central theme: emotions.

Can positive peer feedback break the cycle of negative self-relevant cognitive processes and reduce self-reported anxiety in early adolescents?

Within the LUMC medical research profile Translational Neuroscience innovative multidisciplinary research is performed on a number of severe disorders of the brain, nerves and muscles.

Overkleeft

The master’s specialisation BioTherapeutics at Leiden University is a two-year programme which trains students in research in specific drug delivery techniques. The programme also examines the development of new therapeutic approaches to treat immune-based disorders, such as atherosclerosis, metabolic…

Microbial rhodopsins are photosensitive pigments implemented in the growth and adaptation of a large population of microorganisms.

Are disturbances to the brain, such as Alzheimer's or autism, linked to specific defects in the underlying communication networks in the brain? If this is the case, subtle changes in the networks can act as a marker for brain disturbances. Neuroscientist Serge Rombouts will be investigating this, together…