1,375 search results for “biomarker discovery” in the Public website
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Mast cell-mediated immune modulation in experimental Rheumatoid Arthritis and Atherosclerosis
In this research project, we aimed to obtain more insight in the role of mast cells in the immune driven disorders rheumatoid arthritis and atherosclerosis.
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Medicinal Chemistry
The mission in this division, headed by Laura Heitman, is to design and synthesize novel and better ligands for drug targets. Drug discovery is a lengthy but inspiring adventure. It is often an interplay between academic institutes and pharmaceutical industry, in which scientists at university develop…
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Novel Chemical Modalities
The Novel chemical modalities research group is headed by Assistant Professor Sebastian Pomplun. Sebastian started at the division of Medicinal Chemistry within the LACDR in September 2021. His lab develops technologies for the discovery of novel chemical modalities that can address challenging drug…
- Leiden Loves Science
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About the programme
Drug Discovery and Safety consists of 120 European Credit Transfer System (EC) points.
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Science
The Faculty of Science
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Data Science
The majority of scientists, from archaeologists through to zoologists, collect huge volumes of data. Their massive databases contain large amounts of information which is difficult for humans to filter. With a solid grounding in statistics, we can develop algorithms for analysing and identifying patterns…
- YAL at Night of Discoveries 2023
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Small changes for long term impact: optimization of structure kinetic properties: a case of CCR2 antagonists
Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: Dr. L.H. Heitman
- About this minor
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NMR studies of protein-small molecule and protein-peptide interactions
Promotor: M. Ubbink, Co-promotor: G. Siegal
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Knowledge for the public
Knowledge is everywhere at Leiden University. It is also accessible for those who do not study or work at the University.
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Career prospects
In the Master’s programme in Bio-Pharmaceutical Sciences of Leiden University you are trained for a scientific career in drug research and development.
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LED3 Lecture: Molecular glues in drug discovery
Lecture
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Education that connects to market needs: new course for master’s students focuses on quality in drug development
Immediately connect with the needs of industry with your master’s degree. The new course Practical Aspects of Quality Management in Pharma and Biotech provides just that. The LACDR and LUMC set up the course together with the Biotech Training Facility, located at the Leiden Bio Science Park. The first…
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Curious Minds
At the Leiden Curious Minds Centre, our research focuses on the relationship of exploratory behaviour and discovery learning to curiosity and the way children regulate their behaviour and emotions. We want to improve our understanding of how children can and do become more and more the captain of their…
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Causal Discovery: Challenges and Opportunities
Lecture
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Plan B for particle physics: finding long lived particles at CERN
This thesis discusses the discovery potential of Intensity Frontier experiments.
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The activation mechanisms of G protein-coupled receptors: the case of the adenosine A2B and HCA2/3 receptors
Promotor: A.P. IJzerman
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Structural and functional analysis of proteins involved in natural product biosynthesis and morphological differentiation in Streptomyces
Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.
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LED3 PhD-Postdoc Symposium 2024
Conference
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European Lead Factory
The European Lead Factory has been created with the ultimate goal to develop lead drug candidates to address neglected diseases including bacterial infections, psychiatric disorders and oncology.
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Time is of the essence: investigating kinetic interactions between drug, endogenous neuropeptides and receptor
Promotor: A.P. IJzerman Co-promotor: L.H. Heitman
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Ecology and genomics of Actinobacteria and their specialised metabolism
Filamentous Actinobacteria, such as Streptomyces, produce a plethora of chemically diverse bioactive metabolites that have found applications across medicine, agriculture and biotechnology.
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Phenotypic screening with 3D cell-based assays
Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.
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The molecular secrets of medicinal cannabis
Chronic pain, nausea or vomiting due to chemotherapy. If you suffer from such ailments, medicinal cannabis can be a godsend. Though a downside is that it can make patients high. Therefore, Leiden researchers from the Oncode Institute are investigating alternatives that do not make you high. In Nature…
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Systems pharmacology-based optimization of postoperative morphine treatment
Previous research has found important inter-individual differences in the pharmacokinetics (PK) of morphine in special populations such as children, the morbidly obese or the critically ill.
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Thrips resistance in strawberry: more fruits with less pesticides
Can thrips resistance in strawberry be explained based on secondary metabolite profiles and plant morphological traits?
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Metabolomics and Analytics Centre
The ambition of the Metabolomics and Analytics Centre led by Thomas Hankemeier is to develop innovative analytical strategies for metabolomics-driven health monitoring and systems biology studies. Understanding the intricate balance between health, disease and adaptation to challenges relies on the…
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Research
Knowledge on how to adjust a drug dose in special patient populations such as (prematurely born) neonates or children, obese individuals or critically-ill patients, is not only crucial for novel compounds, but also for existing drugs which are often used in an off-label manner in these special patient…
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Development of a consistent methodology for assessment of the combined effects of metal-based chemicals to lettuce (Lactuca sativa L.)
How to improve the method in quantifying the combined effects of metal-based chemicals?
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Research projects
An overview of research themes and projects at ABS.
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Student projects
Are you looking for a research project?
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Flagships
In CCLS several subgroups have formed, below you can find an overview of these groups with the names of the leading researchers and a short outline of the project.
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To explore the drug space smarter: Artificial intelligence in drug design for G protein-coupled receptors
Over several decades, a variety of computational methods for drug discovery have been proposed and applied in practice. With the accumulation of data and the development of machine learning methods, computational drug design methods have gradually shifted to a new paradigm, i.e. deep learning methods…
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Using AI to improve the Design-Make-Test cycle with Galapagos
Researchers at LED3 are working together with biopharmaceutical company Galapagos to develop software for use in early drug discovery (funded by NWO). This software is able to design molecules with several simultaneously optimized characteristics and will also take prediction reliability into consideration…
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Molecular Pharmacology
In this research group, headed by Laura Heitman, novel receptor concepts in drug discovery are studied, aiming to increase the effectivity of medicines. Many drugs act via so-called G protein-coupled receptors (GPCRs) and therefore our research is mainly focused on understanding and improving drug-receptor…
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Research
The research conducted at the Leiden Academic Centre for Drug Research is clustered within the divisions of BioTherapeutics, Drug Discovery & Safety and Systems Biomedicine and Pharmacology, and the Metabolomics and Analytics Centre.
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Tom van der Wel
Science
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Discovery of Reversible Monoacylglycerol Lipase Inhibitors
PhD defence
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Discovery and characterization of new glucosylated metabolites
PhD defence
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Witnessing the Process of Bacterial Cell Death: Novel Antimicrobials and Their Mechanisms of Action
This thesis describes the antimicrobial discovery strategy developed in our group, the den Hertog Group at the Hubrecht Institute. It includes a cultivation-based screening approach for novel antimicrobial agents from the source of fungi, and a bacterial time-lapse imaging approach for antimicrobial…
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Spectroscopic characterization of exoplanets: From LOUPE to SINFONI
Over the past years it has been discovered that the population of extra-solar planets is large and diverse.
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Drug-target residence time: a case for the adenosine A1 and A2A receptors
Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: Dr. L.H. Heitman
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Societal impact
Research from the Living Lab is important for society. For example, scientists from the Living Lab discovered that the pesticide thiacloprid is up to 2,500 times more harmful to insects than was thought on the basis of regular lab research. Partly because of this discovery, the European Commission decided…
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Beyond the Site
The Saalian archaeological record at Maastricht-Belvédère (the Netherlands).
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CEEDs, the Collective Experience of Empathic Data Systems
The Collective Experience of Empathic Data Systems (CEEDs) consortium developed novel integrated technologies that support experiencing, analysing and understanding of very large datasets.
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Inhibitor Selectivity: Profiling and Prediction
Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.
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Exploring the chemical space of post-translationally modified peptides in Streptomyces with machine learning
The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.
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Pascal chair 2023
Peter Flach is Professor of Artificial Intelligence at the University of Bristol. An internationally leading scholar in the evaluation and improvement of machine learning models using ROC analysis and calibration, he has also published on mining highly structured data, on knowledge-driven and explainable…