2,145 search results for “drug development” in the Public website
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Countering nerve pain caused by chemotherapy with new drug
Nerve pain is one of the most common side effects of chemotherapy. It is therefore one of the biggest reasons for cancer patients to stop treatment early. Darcy Reynolds worked on new drug candidates against this pain during her bachelor's thesis. She developed a new series of molecules that increase…
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the role of Dutch Intelligence Services (AIVD) in the fight against drug trafficking
Minister Grapperhaus wants to use intelligence services in the investigation of drug crime. There are many doubts about this wish in the intelligence world. Paul Abels, Professor by Special Appointment Governance of Intelligence and Security Services at the Institute of Security and Global Affairs (ISGA),…
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The body's own marijuana as inspiration for drug research
Endocannabinoids - the body's own marijuana - are promising departure points for drug research. Professor of Molecular Physiology Mario van der Stelt examines whether inhibiting their production can be a way to fight inflammatory brain disease and to combat obesity. Inaugural lecture 19 October.
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PROPER: ‘Near-patient’ prostate cancer models for the assessment of disease prognosis and therapy
How to identify patients at risk of developing devastating, metastatic disease and facilitate the development of personalised treatment for prostate cancer patients?
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How public money for science leads to new medicines
Public funding for fundamental research is essential for innovation and the development of new medicines. This is demonstrated by Professor Science Based Business Simcha Jong and his colleague Hsini Huang after studying US federal funding restrictions for stem cell research under President George W.…
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Champion in headwind and predictions
It is a stormy Sunday afternoon, with gusts of a whopping 110 kilometres per hour. Chemist Teun Sweere defies the enormous headwind on his city bike and wins the NK Headwind cycling after 22,5 minutes. A new highlight follows six months later: his PhD defence (14 June).
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Chemical Probe Facility
The Chemical Probe Facility is part of the Leiden Early Drug Discovery & Development (LED3) center. Activity-based protein profiling (ABPP) is one of the pillars of chemical biology. ABPP determines the activity of entire protein families in living cells and tissues under physiological conditions, such…
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Bob van de Water
Science
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The chemistry behind cancer drugs: searching for fewer side effects
PhD candidate Dennis Wander searches for the best of both worlds. That is to say: a cancer drug that is effective and also has minimal side effects. To this end, he makes new molecules inspired by two existing medicines. And not without result: ‘We have created a new variant that is very promising.’…
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Quantitative Systems Pharmacology
This research area is focused on the development and application of novel concepts and models in the emerging area of quantitative systems pharmacology (QSP).
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Bioactive Molecules in Animal Sciences
Animal Sciences’ contribution to the Bioactive Molecules research theme includes research on molecules from natural sources, such as plants, insects, and snake venom, with the aim to identify novel anti-cancer, anti-inflammatory, anti-microbial, and anti-diabetic agents.
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Maedeh Nasri
Faculteit der Sociale Wetenschappen
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Susanne Kamerling
Faculty Governance and Global Affairs
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Caroline Archambault
Faculty Governance and Global Affairs
- Research
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Sharing personal health data
Comparing individual health data with group data allows doctors to give personalised advice and patients to learn from one another's experiences. Wessel Kraaij, Professor of Applied Data Analytics, shows how personal data can have a valuable predictive function. Inaugural lecture 24 February.
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Predicting drug behaviour in the brain
Does a drug enter into the human brain once administered in the body?
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Role of leukocytes in metastasis formation in a zebrafish
How do macrophages and neutrophils contribute to metastatic onset?
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Quantitative systems pharmacology modeling of biotherapeutics in oncology
In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.
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First-pass and systemic metabolism of cytochrome P450 3A substrates in neonates, infants, and children
Growth and development affect the metabolism of drugs administered to neonates, infants, and children.
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Development of new antibiotics from plant-originated products
Utilization of plant-originated products as new antibiotics
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Psychologist writes sober book about psychedelic drugs
Psychedelic drugs like magic mushrooms and LSD are embraced by some and seen as lethal by others. Cognitive psychologist Michiel van Elk delved into the world of psychedelic drugs and wrote a surprisingly sober book about them. ‘Without first-hand experience my story wouldn’t be complete.’
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Targeted Therapy for Triple-Negative Breast Cancer
The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.
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Strategy
The Division of Systems Pharmacology and Pharmacy (SPP) aims to develop precision medicine approaches to characterize and predict variation in treatment response and enhance translational drug development strategies.
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Leiden University and LUMC strengthen ties with Janssen pharmaceutical company
Leiden University, the LUMC and Janssen have signed a partnership agreement stating that they will collaborate in different areas, including infectious disease prevention, clinical tests, drug production and e-health. By joining forces, the three partners will be able to provide better, more innovative…
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Mathematical model predicts drug concentration in the brain
Do medicines arrive in the right amount at the right spot in our brain? By making a model that depicts our brain in small 'brain blocks', Esmée Vendel tries to find an answer to this question. Her new, mathematical model predicts the concentration of medicines in the brain over time and space. Vendel…
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Microfluidic 3D cell culture for high throughput screening
There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.
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ZF-CANCER - Developing high-throughput bioassays for human cancers in zebrafish
How can zebrafish research help to understand and fight human cancer?
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Development of Comprehensive and High-throughput metabolomics techniques
A major goal of ABS research is to overcome one of the major bottle-necks in metabolomic research: the lack of a high-throughput infrastructure in which thousands of samples can be processed in a standardized and cost-effective way (max. a few tens of Euro’s per sample for a full metabolome profile).…
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The scientists behind LED3
LED3 is the combined effort of three excellent institutes of Leiden University. Through joined hands, we are able to give rise to a more effective early drug discovery pipeline. Let us briefly introduce the three institutes.
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The activation mechanisms of G protein-coupled receptors: the case of the adenosine A2B and HCA2/3 receptors
Promotor: A.P. IJzerman
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Bioprinting human tissues for drug testing
Bioprinters that enable scientists to engineer complex tissues and organs. It sounds like science-fiction, but not for the scientists of the Alireza Mashaghi lab at the Leiden Academic Centre for Drug Research. The lab has recently been equipped with two state-of-the-art bioprinters: BioX and LumenX+.…
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Ensnaring tumours in their own web
Erik Danen is looking at how to inhibit tumours that do not respond well to medicine – and he is making some headway. The Professor of Cancer Drug Target Discovery studies the interaction between tumour cells and their surroundings. Inaugural lecture on Friday 10 May.
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Parameter optimization toward optimal microneedle-based dermal vaccination
Microneedle-based vaccination has several advantages over vaccination by using conventional hypodermic needles.
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Mathematical modelling of adverse outcome pathways
In this project, we aim to develop mathematical models to mechanistically and quantitatively predict the dynamics of cellular stress pathway activation and its relation with toxic effects when cells are exposed to various toxicants.
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Intervention targets in cognitive development
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Single cell technologies for mechanobiology and mechanopharmacology
Mechanobiology is a major area in biology, however, mechanics is currently a missing element in drug development pipelines. This has led to a high cost for the society. Mechanotoxicity of drugs often appears as a long-term side effect of drugs, and has led to removal of drugs from the market. Furthermore,…
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Zebrafish embryos and larvae as a complementary model for behavioural research
Promotor: Prof.dr. M.K. Richardson
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Novel Chemical Modalities
The Novel chemical modalities research group is headed by Assistant Professor Sebastian Pomplun. Sebastian started at the division of Medicinal Chemistry within the LACDR in September 2021. His lab develops technologies for the discovery of novel chemical modalities that can address challenging drug…
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Examining teachers’ development during a school innovation: stimulating differentiated student talent development
How do teachers’ knowledge, practices, perceptions, job satisfaction and workload in secondary education develop during a school innovation in the context of differentiated student development?
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Targeted biomolecule production for therapeutic use
We aim to develop a drug-delivery method based on the production of biomolecules directly at the target site.
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Research with animals
At Leiden University, in both our biomedical and biological research, we use laboratory animals. Learn more about these specific areas of research and the goals we aim to achieve through these studies.
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Social Anxiety and Normal Development
Why does social anxiety increase in adolescence and how does it grow out of control in some adolescents?
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Research
Tuberculosis causes 1.5 million deaths yearly and anti-tuberculosis therapies are threatened by emergence of drug resistance. Development of innovative drug combinations should be accelerated with the use of translational pharmacological models. Moreover, host-directed therapies (HDT), which stimulate…
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Laura Heitman
Science
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How to develop cancer drugs with less side effects
Lecture, Tuesday Talks: Science Insights
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Tailor-made medicines
More and more medicines are becoming available that target a tumour’s specific traits. The use of chemotherapy is continually undergoing improvement.
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Systems Biomedicine and Pharmacology (MSc)
The two-years master’s specialisation System Biomedicine and Pharmacology at Leiden university focuses on predicting drug response with computational modelling, developing individualised therapies, and developing innovative analytical tools for personalised health strategies.
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Career prospects
In the Master’s programme in Bio-Pharmaceutical Sciences of Leiden University you are trained for a scientific career in drug research and development.
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Career prospects
In the Master’s programme in Bio-Pharmaceutical Sciences of Leiden University you are trained for a scientific career in drug research and development.