In this thesis, we describe the latest advances in SQUID-detected Magnetic Resonance Force Microscopy (MRFM).

This thesis investigates the relations between metabolism and anatomy through the use of Magnetic Resonance Imaging (MRI).

Promotor: T.H. Oosterkamp

Zebrafish is an excellent model organism for studying various human diseases. Due to opaqueness of the adult phase, in vivo studies are restricted to early embryonic stages. This raises the need for rapid sensitive and non-invasive in vivo imaging methods to follow developmental processes, not only…

Promotor: H.J.M. de Groot, Co-Promotor: A. Alia

Alzheimer's disease (AD) is the most frequent neurodegenerative disorder and the primary cause of dementia. The neuropathological features of AD include the occurrence of senile plaques, neurofibrillary tangles, decreased synaptic density, and loss of neurons. An obstacle in the study and treatment…

In this thesis, we show how MRFM can usefully contribute to the field of condensed-matter.

The elementary excitations of magnets are called spin waves, and their corresponding quasi-particles are known as magnons. The rapidly growing field of Magnonics aims at using them as information carriers in a new generation of electronic devices, (almost) free of electric currents.

Ferritin is a spherical metalloprotein, capable of storing and releasing iron in a controllable way. It is composed of a protein shell of about 12 nm and within its cavity, iron is stored in a mineral form.

By detecting the tiny forces between a micrometer sized magnet and the spins of hydrogen nuclei, we can do MRI with a volume resolution that is approximately 12 orders of magnitude better than a conventional MRI.  

Analysis of neuroimaging data requires multiple steps where statistics play a crucial role. The MRI methods research group develops new statistical methods that are accurate, transparent and easy to use.

Promotores: Prof.dr. J. Aarts, Prof.dr. J.M. van Ruitenbeek

A network combining 9 academic research groups and 4 collaborating industrial companies will train the next generation of PhD students and post-doctoral researchers, in developing and applying novel experimental and theoretical methods in the NMR spectroscopy of systems containing paramagnetic metals.…

Our cantilevers have a low intrinsic damping rate: this enables us to measure with low noise, since damping is proportionate to noise. However, when the magnet is close to the surface of a sample we want to study, we measure a much higher effective damping rate. This is caused by magnetic interaction…

Promotor: Prof.dr. H. J. A. Röttgering, Co-Promotor: Dr. M. Haverkorn

Promotor: H.J.A. Röttgering, Co-promotor: M. Haverkorn

Promotor: Prof.dr.ir. J.W.M. Hilgenkamp, Prof.dr. J. van den Brink

Special amplifying agents can make MRI scanners and NMR techniques hundreds of times more sensitive. Leiden physicists have now found a method to test their efficiency. More sensitive MRI scans could for example improve our understanding of cystic fibrosis or Parkinson’s disease. Publication in PCCP…

A deceptively simple, complicated paper

In the Aarts lab we combine or structure materials, mostly in thin film form, in such a way that the hybrid has different and novel properties or functionalities.

Investigating neurobiological endophenotypes of Social Anxiety Disorder

For their research many neuropsychologists use the brain scanners at the LUMC. At the start of the pandemic, the rules for visiting the hospital became stricter and a large amount of psychology research looked as though it would fall through. Thanks to good protocols the researchers can now pick up…

You can still enroll for the master Magnetic Resonance Physics course. It starts at Monday, Nov. 13th 13:30 in HL 226. For more information go to https://studiegids.leidenuniv.nl/courses/show/76629/magnetic-resonance-physics

A computer can look at, and learn from, many more images than a human specialist. AI systems are rapidly becoming indispensable for medical and biological applications. But they still have to learn how to explain their decisions.

What is the relation between brain development and social and cognitive development across childhood, adolescence and adulthood?

What is the relation between brain development and social and cognitive development across childhood, adolescence and adulthood?

Over time Dutch and Indonesian composers, performers and music scholars have inspired each other and they continue to do so. The presence of the Dutch in the Netherlands East-Indies and Indonesia, but also the existence of large diasporic communities in the Netherlands have contributed to a mutual exchange…

Make more fluid: In condensed matter systems, electrons can acquire unusual properties from their interaction with the atomic lattice.

Social anxiety runs in families, but the neurobiology underlying this genetic vulnerability is until now largely unknown. The unique Leiden Family Lab study on Social Anxiety Disorder (LFLSAD) aims to broaden our knowledge with respect to this genetic susceptibility.

In this thesis, I studied the origin and evolution of the non-thermal radiation in merging galaxy clusters.

The main focus of this thesis is the behaviour of two-dimensional materials, namely (anti)-ferromagnetic materials in the first two chapters, which show topological phases, and energetic square ice in the third and fourth chapter.

Promotor: M.A.G.J. Orrit

This specialisation focuses on two important trends in health care: early diagnosis and developing the most targeted patient-specific treatment possible with the shortest possible recovery time and minimal side effects.

A new NMR microscope gives researchers an improved instrument to study fundamental physical processes. It also offers new possibilities for medical science, for example to better study proteins in Alzheimer patients’ brains. Publication in Physical Review Applied.

The imaging group focuses on bio-imaging, image analysis and visualization.

SMR can be used to measure the mass of adsorbed protein to nanoparticles with a high precision in the presence of free protein.

On the largest scale, the Universe resembles a cosmic spiderweb. Most galaxies coexist in small groups within the threads of this web. At the nodes of the threads are enormous groups of galaxies forming the largest structures in the universe still held together by gravity: clusters of galaxies.

The factors that dynamically sculpt the inter-regional correlation of brain patterns are poorly understood. Here, we test the hypothesis that they are shaped by the catecholaminergic neuromodulators norepinephrine and dopamine.

We explore the possibilities to combine magnetic resonance techniques with atomic force microscopy together in a single microscope: the MRI-AFM, also called Magnetic Resonance Force Microscopy (MRFM).

The rapid advances in imaging technology enable to see inside the body with ever increasing detail.

The old dummy MRI scanner in the LUMC was replaced by a 'new' one from Marktplaats (!) at the beginning of July 2020. This device is used specifically for children and adults suffering from claustrophobia, and to introduce the elderly to the scanner.

50 years ago Lauterbur published the basic principle of MRI. Sine then MRI has become more expensive. Professor Andrew Webb describes what is needed to make MRI available for everybody.

How and to what extent the historic house (re-)constructs identity through image-making in China.

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