Cationic peptide amphiphile nanoparticles are employed for co-delivery of immune modulator CpG and antigen. This results in better targeting to the antigen presenting cells and eliciting strong Th1 response, which is effective against the intracellular pathogens.

High throughput microscopy

In order to gain a better insight into the basis of the rapid jasmonic acid (JA)-mediated stress response, an integrated approach using a targeted high-resolution mass spectrometry-based (HRMS) platform, was conducted to monitor the metabolism of JA using the model system of cell suspension cultures…

In this book, Sarah Giest, Assistant Professor at the Institute of Public Administration, provides insight into the collaborative and absorptive capacities needed to provide public support to local innovation through cluster organizations.

The decades around 1800 constitute the seminal period of European nationalism. The lin­guistic corollary of this was the rise of standard language ideology, from Finland to Spain, and from Iceland to the Habsburg Empire. Amidst these international events, the case of Dutch in the Netherlands offers…

Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn, Co-promotor: Dr. M.J.M. Schaaf

These three repors are part of a research project that assesses how military interventions can best prepare the ground for an effective long-term counter-terrorism policy. Three different cases have been studied, and they have each provided the input for the policy relevant recommendations that are…

This is the 2017 paperback release of William Michael Schmidli's The Fate of Freedom Elsewhere, which won the 2013 Foreign Affairs Magazine Best Book of the Year.

Bert Fraussen and Valérie Pattyn theoretically contribute to the existing literature on policy advice by drawing inspiration from niche theory.

My current research focuses on criminality and gender interactions in nineteenth-century Europe. This project uses a comparative methodology to explain gender constructions in a criminal and in a court setting.

This book compares the policies of Australia and Italy towards boat people who have arrived in the two countries since the early 1990s.

Many dangerous diseases such as COVID-19, Ebola and Q fever have jumped from animals to humans. But it is not only because of these diseases that we should include animals in our health policy, but also because of their right to health.

The European Research infrastructure for science, technology and innovation policy studies (RISIS2) aims at building a data and services infrastructure supporting the development of a new generation of analyses and indicators. To develop a deeper understanding of knowledge dynamics and policy relevant…

On December 12th, Andreas Krogull succesfully defended his doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Andreas on this great result.

How do people experience ‘inclusion’ in sports? How can experiential expertise enhance policies in sport and inclusion? This research internship at The Mulier Institute enables a student to investigate these issues from a qualitative research perspective.

In this article for Studies in Conflict & Terrorism, the authors analyse the evolution and interplay of national policies and international diplomacy on cyber terrorism within and across the UNSC’s permanent five members and the UN process on cyber norms (GGE and OEWG).

Despite the value of technology integration for educational equity and quality being emphasized by numerous studies, many gaps exist about how technology integration can be approached in policy plans, implemented in pedagogical practices, and embraced by teachers, students, and parents.

Does foreign aid promote human rights?

The lack of success of new CNS drugs in clinical development is in part due to the complexity of the CNS, unexpected side effects, difficulties for drugs to penetrate the brain, but also by the lack of biomarkers.

The power of personalized nutrition lies in being able to conduct clinical research on healthy people while capturing metabolic markers sensitive to the impact of environmental and metabolic stressors (e.g. diet, changing sex hormones and the menstrual cycle).

The main question addressed in this thesis is how we can best conceive the contrast between a priori and empirical truths.

The RISIS project aims at creating a distributed research infrastructure to support and advance science and innovation studies. This will give the field a strong scientific push forward, and at the same time, provide a radically improved evidence base for research and innovation policies, for research…

In December 2014, Leiden University’s Institute of Security and Global Affairs with the Australian National University’s Asia-Pacific College of Diplomacy and the International Centre for Counter-Terrorism, commenced a research project to assess how (temporary) military interventions can best prepare…

It is often said that the true character of a person is only revealed in a crisis. In these days, the coronavirus causes concern about the true state of the multilateral system. Political scientist Gisela Hirschmann (Leiden University) is worried about the future of multilateralism.

Across Europe, the need for a more dynamic governance and a better societal integration of research and innovation is increasingly appreciated. Internal drivers of change (such as the digitalization of science) and political will to better align with societal needs and concerns are bringing about aspirational…

The aim of this project is to explore the use of statistical interaction models to quantify cross-omics and omics-drug interactions in large-scale clinical and experimental datasets

This research project focuses on the thoughts of ethnicity and political orthodoxy in Medieval China by investigating Wang Tong’s works.

This research project focuses on the interaction of Buddhist institutions, Chinese central and local governments, and local gentry in the 'transforming temples into schools' movement.

How we think about and act on the usefulness of scientific research has epistemological and political implications: what knowledge consists of, how it comes about and to what ends. In this dissertation, I situate the usefulness of scientific research in concrete places for knowledge exchange. The exchange…

This paper written by Alexandre Afonso, Assistant Professor and Researcher at Leiden University, argues that gender norms and the political strength of the left were important structuring factors regarding why European countries choose migrant labour to expand their labour force in the decades that…

The project Going Dutch investigates why the link between being or becoming Dutch, and knowledge of Standard Dutch is so often taken for granted in public discourse, by diving into its historical roots.

Whilst government’s ability to design ‘context-specific’ regional innovation policy is generally assumed to depend on the region’s decision-making power, the aim of this study is to investigate how regional government matters. In order to open up the black box of policy design, the study develops a…

In online games conflicts between players may arise. Novin, Bos, Stevenson and Rieffe investigated factors that may explain why some adolescents react more angrily than others in this type of situation. In their realistically designed gaming environment, the (pre-programmed) fellow player suddenly started…

Promotor: Prof.dr. P. Hooykaas, Co-promotor: Dr. R. Offringa

PhD defence

Source: Biosens Bioelectron, Volume 74, pp. 233-42 (2015)

The aim of this work was to study the applicability of antigen-coated pH-sensitive microneedle arrays for effective vaccination strategies. Therefore, a model antigen (ovalbumin) was coated onto pH-sensitive (pyridine-modified) microneedle arrays to test pH-triggered antigen release by applying the…

This paper written by Vydra and Kantorowicz answers the research question ‘What policy-relevant information does Twitter contain?’ as well as the research question ‘How does this information change between a period of normalcy and a period of crisis?’

Using the principles of Industrial Ecology in Environmental Policy making in two cases: transition to a hydrogen economy and chlorinated compounds.

Policy Note Insecurity in Burkina Faso – beyond conflict minerals: The complex links between artisanal gold mining and violence

What drives the restrictiveness of immigration reforms? Political scientists Katharina Natter (Leiden University), Mathias Czaika (Danube University Krems) and Hein de Haas (University of Amsterdam) analysed immigration reforms in 21 Western immigration countries between 1970 and 2012. They found that…

Promotor: E.F. Smets Co-promotor: J. Geml

Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.

On 7 May 2020, Jolanda van der Vliet defended her thesis 'The International Legal Protection of Environmental Refugees. A human rights-based, security and State responsibility approach'. The doctoral research was supervised by Prof. N.J. Schrijver and Prof. J.J.C. Voorhoeve.

The shift from response to recovery is now noticeable as the world moves past the paralyzing effects of the COVID-19 pandemic. This book explores responses to the pandemic by international, regional, and local institutions, multilateral action, and crisis prevention efforts at different levels of governance,…