1,652 search results for “respiratory disease” in the Public website
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Open call to BRIN-LDE Academy
The 2022 Academy is co-organised by Leiden, Delft Erasmus Universities (The LDE Alliance) from the Netherlands and the National Research and Innovation Agency (BRIN). Aim of this five day programme is co-creation in the field of teaching and research on sustainable urbanisation. It also aims to facilitate…
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ImageInLife: Training European experts in multilevel bioimaging, analysis and modelling of vertebrate development
How can novel bioimaging technologies and vertebrate model species be used to gain a better understanding of early cellular behaviours with the ultimate goal to increase our understanding of human development and disease processes?
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Frits Rosendaal
Faculteit Geneeskunde
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Annemarie Meijer
Science
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Zebrafish: a new engraft model to study Ewing sarcoma progression
Can zebrafish provide a fast, sensitive in vivo vertebrate model for identifying novel mechanisms of Ewing sarcoma progression and for development of new anticancer compounds in a time- and cost-effective manner?
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Teeth Tell Tales
A multi-disciplinary approach to past lifestyles and cultural practices
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Distance-based analysis of dynamical systems and time series by optimal transport
Promotor: S.M. Verduyn Lunel
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Chemokine signaling in Tuberculosis and Salmonella infection
Who benefits from CXCR/CXCL chemokine signaling during infection: host or pathogen?
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Topic: Movement and mental functions
Our ability to learn and control movements is essential for engaging in goal-directed behaviour. From buttoning your shirt and driving a car, to cooking dinner and brushing your teeth -- our actions in daily life rely on this ability.
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Photocleavable activity-based acid glucosylceramidase probes
Lysosomal acid glucosylceramidase (GBA1) is a lysosomal enzyme that degrades glucolipids with its main substrate being glucosylceramide (GlcCer). Defects in the GBA1 gene lead to glycosphingolipidosis Gaucher disease (GD), in which the hydrolysis of GlcCer is impaired and therefore, it accumulates in…
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Small changes for long term impact: optimization of structure kinetic properties: a case of CCR2 antagonists
Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: Dr. L.H. Heitman
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Live or let die: the intracellular fate of pathogenic mycobacteria
How do mycobacteria subvert the defenses of host immune cells?
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Alumnus Charlotte Poot developed a hospital app for children
Charlotte Poot (31) is co-founder and chair of Hospital Hero, an app that prepares children for a hospital visit. She studied and obtained her PhD at the LUMC.
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Targeted biomolecule production for therapeutic use
We aim to develop a drug-delivery method based on the production of biomolecules directly at the target site.
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‘Seeing voices’: the role of multimodal cues in vocal learning
Can birds - like people- ‘see’ voices and learn how to sing by listening and watching?
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The serosa: an evolutionary novelty in insect eggs
What is the function of the insect serosa?
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MeRGeR: Physiological significance of the glucocorticoid and mineralocorticoid receptor signaling in the innate immune system
Does the mineralocorticoid receptor play a role in the effects of cortisol and synthetic glucocorticoids on the immune response?
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Polar auxin transport: translating environmental signals into plant developmental responses
1. What is the exact role of PIN proteins in PAT? 2. How is PIN polarity established, and how is it modulated by AGC kinase-mediated phosphorylation? 3. What is the role of the AGC kinase, as modulators of PAT, in translating environmental signals, such as gravity, light or mechanical stress, to plant…
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Conquering the fortress: New strategies for the treatment of tuberculosis
Can we exploit the cell death machinery of the host to develop new host-directed anti-TB treatments?
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The quest for new medicines against tuberculosis
Can drug screening for tuberculosis treatment be made more efficient?
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Modulation of the immune system for treatment of atherosclerosis
Cardiovascular diseases are the primary cause of death in the world with atherosclerosis as primary underlying cause.
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Topic: Stigmatization in patients with chronic health conditions
Imagine that you have a chronic skin condition, characterized by red patches of itchy, scaly skin. You regularly notice people staring at your skin and sense their reluctance to shake your hand. Or imagine that you have Parkinson's Disease, causing your hands to tremble and making it difficult for you…
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ERC-subsidie om uit te zoeken hoe kinderen luchtweginfecties te lijf gaan
De crèche en het klaslokaal zijn misschien wel de meest gunstige plekken voor ziekteverwekkers. Toch is er relatief weinig bekend over hoe kinderen reageren op virussen en bacteriën en hoe het komt dat sommige kinderen veel beter beschermd zijn dan anderen. Simon Jochems, onderzoeker aan het Leids Universitair…
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Treatment before patients develop rheumatism provides lasting relief
Early treatment benefits patients who have not fully developed rheumatoid arthritis but are in the preliminary stages of the disease. This is what researchers from the Leiden University Medical Centre (LUMC) have reported in The Lancet. Patients in the pre-arthritis stage who were temporarily prescribed…
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Leiden University Medical Center
In the Leiden University Medical Centre (LUMC) we strive to improve health care and the health of people.
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First patients start earning discounts with healthy living
Heart patients who maintain a healthy lifestyle can start earning discounts at shops or for trips out. The Tergooi Hospital is the first in the Netherlands to introduce this unique method that was co-developed by the research group headed by Professor of Health Psychology Andrea Evers and the Leiden…
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Research
Research at the Macromolecular Biochemistry group is comprised of the following research themes:
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Leiden Professor convenes precision medicine workshop at Harvard's Radcliffe Institute
Professors Simcha Jong (Leiden University) and Rifat Atun (Harvard University) convened an exploratory seminar to discuss challenges for health systems in realising the potential of precision medicine at Harvard University’s Radcliffe Institute for Advanced Studies in Cambridge, MA on 17 April 2017.
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Hypoxic Signalling and Tuberculosis
IBL-researcher Phil Elks in the group of Annemarie Meijer won the Cell Observatory Publication of the Year 2013. He received the award for his paper in PLoS Pathogens, showing that activation of hypoxia signaling protects against mycobacterial infection.
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Linking aboveground-belowground interactions and plant-soil feedback to improve pest control and sustainability in greenhouse cut-flowers
We examine how soil inoculation influences aboveground organisms (i) directly, and indirectly via (ii) its effects on plant chemistry or volatile emission, or via (iii) mediating the effects of belowground pathogens on aboveground organisms via the shared plant.
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Novel immunomodulatory drugs for tuberculosis treatment
Can drugs that target host signaling pathways be used to eradicate antibiotic-resistant bacteria?
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Imaging of biomaterial-associated inflammation and infection using zebrafish
Which immune mechanisms are involved in host defense against Staphylococcal infection?
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Inexhaustible source of human heart muscle cells allows strong reduction of animal testing
Researchers at the Leiden University Medical Centre (LUMC) have managed to culture human heart muscle cells on a massive scale. This is an exceptional achievement because it is very difficult to replicate heart muscle cells outside the body. Using a special technique, the researchers have now created…
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Education
Cooperation on education with China stimulates innovation and brings a different perspective and new content to classrooms.
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Understanding plant transgenesis
How is Pol θ responsible for T-DNA integration, and how do other DNA double-strand break repair pathways interact with Pol θ? How may we manipulate T-DNA integration to stimulate error-free integration at a predetermined genomic site?
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Development of new antibiotics from plant-originated products
Utilization of plant-originated products as new antibiotics
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Role of Chemokine Gradient Sensing in Ewing Sarcoma Progression, Angiogenesis and Immune Targeting
What are the biological and biophysical mechanisms that control chemokine gradient sensing and migration of immune, endothelial, and tumour cells in tumour development?
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Reducing daily-stress breaking a habit
With this thesis the PhD-candidate aims to enrich the body of evidence concerning the relation between stress and health, and the mediating role of (un)conscious perseverative cognitions, which is captured in the extended perseverative cognition hypothesis.
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Innovative Leiden research receives NWO grant
On January 24 Professor Annemarie Meijer and Dr Sander Wezenberg received a NWO grant for their research. The grant was awarded within the Open Competition Domaine Science-M programme and is intended for innovative research areas that can form the basis for the research themes of the future.
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Innate immune defence against intracellular pathogens
What are the host immune defence mechanisms that control intracellular infections and how are these subverted by pathogens?
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Biological and Soft Matter Physics
Research groups in the Biological & Soft Matter Programme unravel mechanisms in biological processes and develop novel bio-inspired soft materials.
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R-ELEVATION
How do plant defense genes get activated?
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Herman Spaink
Science
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Paul Hooykaas
Science
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Veronique de Gucht
Faculteit der Sociale Wetenschappen
- IBL Spotlight - Development & Disease
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How these young researchers are preparing for their first scientific conference
Three Psychology students will present a poster of their thesis research on Alzheimer’s and dementia at the international conference AAIC Neuroscience Next. ‘I remind myself to recognise - without fear or shame - when I don't know something.’
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Immunity, Infection and Tolerance
The LUMC has a longstanding tradition researching the role of the immune system in infectious diseases, transplantation and auto-immune diseases.
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Clinical applications of (pharmaco)metabolomics
The predication of the effect (efficiency and toxicity) of a drug in a patient is very important in (i) clinical decision support and (ii) the development of novel drug treatments. We apply our technology and methods to find biomarkers for key disease pathways and toxicity in clinical studies and in…
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Seminar: POPNET Connects with with Naja Hulvej Rod
Lecture