A high performance computer or supercomputer owes its massive processing capacity to the fact that it chops a single overarching task into a whole series of smaller tasks. It simultaneously tackles each of those smaller problems.

Natural Computing investigates algorithms and phenonema based on nature to create better and new computer science innovations.

Promotor: S.J. Edixhoven, L.D.J. Taelman

The Computer Support group provides dedicated support for the computing infrastructure of Leiden Observatory

Research in this group, headed by Gerard van Westen, focusses on computational methods integrated in different parts of the drug discovery process. More specifically, topics include innovative treatments for cancer, selectivity modeling, translational research, allosteric modulation, drug resistance…

The master's specialisation Bioinformatics at Leiden University focuses on research, development and application of computational tools and approaches for expanding the use of biological, medical, behavioral and health data.

In ‘Dimensions of Free Speech’, Devrim Kabasakal Badamchi (Leiden University Institute of Political Science) offers a new theoretical framework for free speech by critically analysing the major justifications for free speech. Kabasakal Badamchi argues for a justification: namely the double-grounded…

High Performance Computing (HPC) is becoming ever more important as a research tool in many research areas across all research domains. A University facility, providing serious computational capabilities, combined with easy and flexible local access, is a strong advantage for these research areas. It…

Promotor: C.W.J. Beenakker, Co-Promotor: A.R. Akhmerov

Large-scale computing infrastructure, such as supercomputers, cluster, and clouds, are already pervasive, most members of our society interact with them daily: social networks, government services, media streaming services--all systems heavily interfacing with the members of our society--are powered…

The group Theoretical Physics of Life Processes, led by Helmut Schiessel, focuses on the physics of chromatin, the DNA-protein complex that fills the nuclei of eukaryotic cells.

Promotor: Roeland M.H. Merks

The goal of the MODOMA-project is to create a computer model of language acquisition.

This book brings together a collection of emergent research that moves the debate on desistance beyond a general consideration of individual and social structural influences.

LUMC Technology Focus Area (TFA) Data Analytics is een samenwerkingsverband van verschillende onderzoeksgroepen in het LUMC die nieuwe kwantitatieve en computationele methodologie ontwikkelen voor biomedisch en klinisch onderzoek.

Sewer pipes are an essential infrastructure in modern society and their proper operation is important for public health. To keep sewer pipes operational as much as possible, periodical inspections for defects are performed.

An algorithm is discussed to compute the exponential representation of principal units in a finite extension field F of the p-adic rationals.

The NEASQC project brings together academic experts and industrial end-users to investigate and develop a new breed of Quantum-enabled applications that can take advantage of NISQ (Noise Intermediate-Scale Quantum) systems in the near future. NEASQC is use-case driven, addressing practical problems…

Epithelial-mesenchymal plasticity (EMP) and tumor cell migration play an important role in cancer progression, and an improved understanding of the mechanisms underlying these concepts is essential for developing new targeted approaches.

Science, Leiden Institute of Advanced Computer Science (LIACS)

Audiovisual and Digital Ethnography is a state-of-the-art introduction to this dynamic and growing subject. The authors explain its fundamental aspects in a clear and systematic way.

In this research group, led by Dr. Joost Beltman, the aim is to employ mathematical and computational dynamical modelling approaches in order to quantitatively and mechanistically understand the dynamical behaviour and regulation of intracellular networks of genes, proteins and metabolites as well as…

This thesis covers various applications of topology in condensed matter physics and quantum information.

What tools can be applied to measure the output, outcome and impact of science communication efficiently and effectively?

Science, Leiden Academic Centre for Drug Research (LACDR)

Leiden Embedded & Real-time Computing (LERC) is an expert lab and leader in advanced research on embedded and real-time systems and software. The main mission of LERC is by its research to contribute in a highly innovative way to the system-level design of embedded and cyber-physical systems and software…

This dissertation presents new cryptographic protocols, which can be divided into two families.

Promotor: S.J. Edixhoven

The Dutch Research School for Theoretical Physics (DRSTP) has received excellent ratings from an independent international committee. The DRSTP is a school for PhD training which has grown out of a collaboration between the theoretical physics departments at six Dutch universities—including Leiden—and…

There is a need for alternative methods to replace, reduce and refine (3R) animal experimentation. Combining experimental data from high-throughput in vitro studies with in silico modeling is a promising approach to unravel the effect of chemicals on living cells and to gain a better understanding of…

The 18.8 million euro NWO Zwaartekracht grant for quantum software which Amsterdam, Delft and Leiden landed collectively, means for Leiden University among others the appointment of two new permanent scientific staff members, who will each form their own research group, divided among Computer Science,…

Design of a Linguistic System for Interstellar Communication Based on Logic

This dissertation provides an account of polar questions in Italian dialects from a typological, theoretical and empirical perspective.

Machine learning - on classical computers- has made great progress in the past five years. Computer translation of speech and text is just one example. In Leiden, some researchers expect that machine learning, empowered by quantum systems, even if they only contain a few dozen qubits, can lead to a…

In this project we study the properties of statistical- and rule-learning mechanisms in relation to the acquisition and evolution of language. We ask to what extent these mechanisms are unique to humans - or to human language - by comparing the acquisition of vocal structure in two species: humans (infants)…

In the current global context, there is a pressing need to address sustainable energy supplies to safeguard our Planet and its ecosystems. The choices made by human society have a significant impact on genetic evolution and climate.

The research programme Statistical Science is concerned with the analysis and interpretation of masses of data, the quantification of uncertainty using probability models, and the development and benchmarking of algorithms and methods with these aims.

In this thesis it is posed that the central object of preference discovery is a co-creative process in which the Other can be represented by a machine. It explores efficient methods to enhance introverted intuition using extraverted intuition's communication lines.

LIACS prof. Grzegorz Rozenberg is one of the world leaders in research on Theoretical Computer Science and Natural Computing. He is often called the guru of Natural Computing.

LIACS prof. Grzegorz Rozenberg is one of the world leaders in research on Theoretical Computer Science and Natural Computing. He is often called the guru of Natural Computing.

Simulations of galaxies help researchers understand astronomical observations better. The EAGLE simulation, a large project in which Leiden astronomers play a leading role, shows the evolution of the Universe, from just after the Big Bang to the present day.

In the traditional theory of linear elasticity, superposition dictates that the response of a material does not depend on the sequence of the applied mechanical actuations.

This thesis aims at contributing to our understanding of the semantic and prosodic properties of object foci in Greek, employing theoretical and experimental tools.

Promotor: Prof.dr. J.N. Kok

We review the state-of-the-art in the theory of dissociative chemisorption (DC) of small gas phase molecules on metal surfaces, which is important to modeling heterogeneous catalysis for practical reasons, and for achieving an understanding of the wealth of experimental information that exists for this…

Optical projection tomography (OPT) is a tomographic 3D imaging technique used for specimens in the millimetre scale.

With the recent rise and fall of IS, academics and policy makers around the world are expressing concerns about the fate of children of former foreign fighters. Will they follow in their parents’ footsteps? In this paper, Layla van Wieringen, Daan Weggemans and Marieke Liem argue that in light of this…

A P300-based Brain Computer Interface character speller, also known as P300 speller, has been an important communication pathway, under extensive research, for people who lose motor ability, such as patients with Amyotrophic Lateral Sclerosis or spinal-cord injury because a P300 speller allows human-beings…

Researchers of the Leiden Institute of Advanced Computer Science (LIACS) will develop a training programme the next generation of early stage researchers (ESRs). During a four years project they will be trained to approach industrial challenges in a holistic manner by developing solutions in an automotive…

This thesis proposes multiple paths towards the development of a performance practice in Computer Music.