In STAYAHEAD data-intensive approaches are being developed to ”decode the human immunome” with a focus on a global vaccine strategy. They have developed a rapid mass spectrometric test to analyse in real-time large numbers of variants of SARS-CoV-2 and the host immune response, and use these data to…

Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken

The outbreaks of AIDS and COVID-19 showed clearly how infectious viruses can influence people’s lives. Investigating the changes in the host metabolism may provide a paradigm shift to consider immune-metabolic interactions as therapeutic targets.

Following current regulations regarding the attempts to constrain the effects of the Corona virus outbreak, the University of Leiden has cancelled all physical forms of teaching until 6 April. As conference organisers, we will use this period to consider how to proceed with the conference. In the most…

Physicists, including Leiden researcher, Sanli Faes, have devised a new technique for studying processes at microscale rapidly and extremely precisely. This new method will make it easier to develop antiviral medication. And it doesn’t stop there. Publication in ACS Nano.

Although Ebola is a virus with significant fatality rates, we still lack effective countermeasures to battle it. To change this, Alireza Mashaghi and his colleagues from the Leiden Academic Centre for Drug Research have successfully developed an organ-on-a-chip model that imitates the most dangerous…

Data science is of vital importance in preventing future outbreaks of viruses, Professor of Data Science Aske Plaat argues. Inaugural lecture entitled ‘Data Science and Ebola’ on 13 April.

Joost Beltman (LACDR, Leiden University) has provided novel insights in the way T cells migrate towards virus-infected cells. This was accomplished by a combination of experimental research in the group of Ton Schumacher (Dutch Cancer Institute, NKI) and computer simulations in collaboration with Rob…

Due to the by now world-wide Covid19 restrictions on travelling and holding meetings, the committee has decided to cancel the conference in June. We are now looking into postponing the conference (either to a later date in 2020 or to 2021). We will keep you informed about any further developments. All…

A COVID-19 vaccine that specifically instructs the immune system to produce T-cells rather than antibodies is shown to provide good protection in a mouse model, Leiden University Medical Center (LUMC) researchers report in Nature Communications. According to them, the alternative vaccine may offer a…

Today, everybody and everything produces data. People produce large amounts of data in social networks and in commercial transactions. Medical, corporate, and government databases continue to grow. Sensors continue to get cheaper and are increasingly connected, creating an Internet of Things, and generating…

A flu virus could cause a pandemic. And then we would be poorly armed because flu viruses are starting to become resistant to flu medications like Tamiflu. Chemist Merijn Vriends successfully worked on an improved version of such medications. He will be awarded his doctorate on September 12th.

All acute care staff at Leiden University Medical Center have received their first and sometimes even their second dose of the coronavirus vaccine. But how long will you be protected after vaccination and what does the genetic material of the virus do in the vaccine? Our virologists Ann Vossen and Leo…

Moritz Jesse, Associate Professor at the Europa Institute Leiden, was a speaker at the International Conference European Constitutionalism And the Virus of Distrust Conference, which took place on 27 and 28 April in Prague. The Conference brought together academics from all over the European Union to…

Professor of Ecotoxicology Martina Vijver had planned an eight-week field work course for her students, but the corona virus threw a spanner in the works and Vijver had to come up with a new plan at short notice. ‘Without the help of my own network and that of my colleagues this would have been very…

Bacteria temporarily live without their cell wall if dangerous viruses are near. A remarkable feature, as the cell wall is a sturdy barrier against threats. Still, the discovery has a logical explanation ánd might be of a consequence for fighting pathogenic bacteria, according to Véronique Ongenae,…

Dying from viral infection due to organ failure and blood loss: we still know little about how it can happen. Among other things, Huaqi Tang developed an organ-on-a-chip to figure it out. 'These technologies can offer unprecedented opportunities to fight the viruses that threaten our society.' Tang…

Seasonal influenza vaccines provide protection against matching influenza A virus (IAV) strains mainly through the induction of neutralizing serum IgG antibodies. However, these antibodies fail to confer a protective effect against mismatched IAV. This lack of efficacy against heterologous influenza…

Phage therapy is a novel yet unmatured therapeutic approach in the face of the crisis of antimicrobial resistance (AMR). Dr. Tingjie Guo received a grant from the Elise Mathilde Fund and the LUF to develop innovative phage-antibiotic combination treatment strategy for combating AMR.

A team of students from Leiden won the iGEM international biology contest in 2020 with their Rapidemic mobile testing kit. The kit makes it easy to detect viruses. The team has now been nominated for the Most Innovative Student in the Netherlands prize. Cast your vote and help them develop their inv…

The genetic code of the new coronavirus has been found: it is closely related to the SARS virus from 2003. Professor of Molecular Virology, Eric Snijder, has been researching coronaviruses for years. We asked him a few questions about the outbreak. ‘It’s still unclear whether this new virus is more…

The potential of bioneedles to deliver influenza vaccines was investigated.

What are 'defects' and mechanical properties of mosaics of different shapes of tiles?

The Viral Vector Facility produces batches of lentivirus and adenovirus for preclinical research within the LUMC. And it assists researchers to produce their own virus.

VODAN Africa started as a platform to enable access to critical data needed from Africa to fight the novel COVID-19. The initiative was inspired by the experience from the Liberia Ebola Virus outbreak in 2014: early detection requires contact tracing. Inclusion of the most vulnerable is critical to…

Please find below links to articles / events that might be of interest.

New and reemerging infectious diseases call for innovative and efficient control strategies of which fast vaccine design and development represent an important element.

In the hunt for a vaccine against cervical cancer, fundamental knowledge about the immune system and organic chemistry have been brought together and have already resulted in a vaccine that is now being tested in clinical trials. Scientists are now working hard on an improved variant.

Leiden researchers are helping develop safe COVID-19 vaccines.

PhD defence

PhD defence

PhD defence

PhD defence

What Accounts for the Variety of National Policy Responses to the COVID-19 Pandemic in Europe?

Leiden chemists discovered a new mechanism which might explain how multiple sclerosis shifts to a more severe form. Their findings contribute to unravelling the mysterious course of the disease. They have published their findings in the journal Biochemistry.

Promotor: T.H. Oosterkamp

Promotors: Prof.dr. P.G.L. Klinkhamer, Prof.dr. P.M. Brakefield

Associate professor at the Natural Products Laboratory, Institute of Biology, Leiden University - the Netherlands

Are you graduating at the Faculty of Science? Or are you supervising a PhD student? At the Graduate School of Science you find support at every phase of your PhD.

Promotoren: G.F.A. Kersten, W. Jiskoot, Co-promotor: J-P. Amorij

The current hepatitis B vaccines need to be stored and transported under refrigerated conditions (2-8 degrees C). This dependence on a cold-chain is highly challenging in areas where hepatitis B virus infections are endemic.

Together with two other authors, Jaroslaw Kantorowicz from ISGA investigates the susceptibility to believing in misinformation.

Chapter 2 describes a post-synthetic methodology to introduce a fluorescent label in highly lipophilic, Pam3Cys based conjugates.

Natascha van der Zwan, Assistant Professor at Leiden Univeristy, together with two other authors, wrote a book that explored some of the ways coronavirus is impacting the global capitalist system – and how this could change for better and for worse.

The CMCB brings together microbial cell biology expertise in Leiden. It aims at optimal resonance between the groups and maximal exploitation of the available infrastructure and to develop innovative cross-boundary technology platforms.

Honorata Mazepus and Jaroslaw Kantorowicz are assistant professors at the Institute of Security and Global Affairs. Mazepus and Kantorowicz are one of the authors of this article in Nature on the role of national identity on public health support during global pandemics.

PURPOSE: The aim of the study was to develop a cheap and fast method to produce hollow microneedles and an applicator for injecting vaccines into the skin at a pre-defined depth and test the applicability of the system for dermal polio vaccination.

The CIGR brings together a diverse range of unique expertise in genome research rooted in biology, chemistry and physics. Members of the CIGR investigate genome folding and genome transactions. An important aspect is direct as well as long term relevance for medicine.

Dr. Foks obtained this fellowship for the project “Can promotion of efferocytosis induce regression of atherosclerosis?”, in which she aims to identify novel targets to promote regression of atherosclerosis. This research grant allows her to initiate independent research for the next three years.