Systems with local constraints is a new finding in recent researches on complex systems. The heterogeneous spatial interactions and the temporal dependencies among those numerous units make it difficult to describe by traditional statistical physics.

In this thesis we will explore the use of fuzzy systems theory for applications in bioinformatics.

We have studied the impact of particle shape anisotropy, multivalent interactions and flexibility on systems of micron-sized colloidal particles.

Electoral Systems and Turnout: Evidence From a Regression Discontinuity Design. In this article, published on the website SAGE research methods, authors Jaroslaw Kantorowicz and Tobias M. Hlobil discuss how a Regression Discontinuity Design can be executed.

In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.

We have developed a microfluidic platform for complex 3D organotypic cell cultures (so-called organ-on-a-chip systems) which are suited for integration in 96 or higher well plate format.

In the hunt for a vaccine against cervical cancer, fundamental knowledge about the immune system and organic chemistry have been brought together and have already resulted in a vaccine that is now being tested in clinical trials. Scientists are now working hard on an improved variant.

Promotor: Prof.dr. J. Kuiper

What is the environmental impact of different waste collection systems across Europe? How can the collection be improved when considering collection, sorting, and treatment, as well as use options for secondary materials?

Haunted Europe offers a comprehensive account of the British and Irish fascination with a Gothic vision of continental Europe, tracing its effect on British intellectual life from the birth of the Gothic novel, to the eve of Brexit, and the symbolic recalibration of the UK’s relationship to mainland…

In this book liposomes are explored as delivery system for allergen-specific immunotherapy. Both cationic and anionic formulations are prepared with Bet v 1, one of the allergens in birch pollen.

Pathways of toxicity

Knowledge and culture subproject 2:

In autoimmune diseases such as rheumatism and diabetes the immune system attacks autologous proteins. Leiden researchers are trying to discover how this comes about.

Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.

Promotor: W.Th.F. den Hollander Co-Promotor: F.M. Spieksma

On 25 January 2018 Yannick van den Brink defended his doctoral thesis titled ‘Voorlopige hechtenis in het Nederlands jeugdstrafrecht’ (‘Pre-trial detention in the Dutch juvenile justice system’). The doctoral research is supervised by Professor Ton Liefaard and Professor Mariëlle Bruning.

The key characteristic of active matter is the motion of an emergent collection (such as a flock of birds), which is driven by the consumption of energy by its active components (i.e. individual birds).

Tax scandals, like the Panama Papers, the Paradise Papers, and the Pandora Papers, have made taxation a major topic of public debate. Learn more about this in the new minor Tax and Society: Building a Sustainable and Fair Tax System.

Promotor: Prof.dr. M. Ubbink

This thesis deals with the use of sound in interactions in the context of participatory systems and data sonification. We investigate an interactive environment where participants perceive information of the data through sound elements.

Does powerlessness and dependence lead to the legitimation of the social, political, and economic status quo and of those in authority?

The Collective Experience of Empathic Data Systems (CEEDs) consortium developed novel integrated technologies that support experiencing, analysing and understanding of very large datasets.

The United Kingdom’s relationship with the European Union was supposed to be definitively settled several times during the past decade – yet it was not. The 2016 referendum brought about a surge in interest in legal questions, especially of EU law and international economic law. This presented scholars…

Academic writing: it’s something that all students have to face. And it can be really quite difficult. The writing coaches at the Humanities Writing Center will therefore support you at every stage of your studies.

The Horizon 2020 project Sybil-AA (Systems Biology of Alcohol Addiction) focuses on modeling and validating disease state networks in human and animal brains for understanding pathophysiology, predicting outcomes and improving therapy in alcohol addiction. Alcohol addiction, the most severe form of…

On 17 December 2018, Dejian Kong defended his thesis 'Civil Liability for Damage caused by Global Navigation Satellite System'. The doctoral research was supervised by Prof. dr. P.M.J. Mendes de Leon.

Generations of Leiden students and academics have done archaeological research into the early medieval history of Oegstgeest. This makes this old settlement one of the best-documented sites from that era. In a new book, Leiden researchers take stock.

The first objective is to create a catalogue raisonée, i.e. a structured database that will store the main attributes of each town in a standardized format database, which will be freely accessible when completed; the second objective is to exploit theories and methods that can help us to understand…

The overall objective of this project is to identify novel drug candidates that are capable of slowing down the progression of neurodegeneration in the subset of Parkinson’s disease (PD) patients with overt mitochondrial dysfunction. Multimodal phenotypic characterisation of cohorts of monogenic PD…

This thesis presents insights from our study of various correlated electron systems with a scanning tunneling microscope (STM). In ordinary metals, electron-electron interactions exist, but get substantially screened due to the sheer number of electrons.

To what extent is the legislation and use of pre-trial detention of juveniles in the Netherlands in compliance with international children’s rights standards?

On 11 November 2021, Mariana Gkliati defended the thesis 'Systemic Accountability of the European Border and Coast Guard'. The doctoral research was supervised by Prof. P. Rodrigues and Prof. L. Besselink (UvA).

Promotor: Prof.dr. E.F.A. Deprettere, Co-promoter: Todor P. Stefanov

Students with learning problems experience difficulties in reading, writing, and content-area learning into and throughout their secondary-school years

This thesis focuses on two processes involved in fighting infections: metabolism and immune cell motility and navigation.

A tidal basin is an inland sea which is almost entirely enclosed by land and connected to the open sea by a tidal inlet. Through the tidal inlets interaction takes place between the tidal basin and the open sea.

Cardiovascular diseases are the primary cause of death in the world with atherosclerosis as primary underlying cause.

Intelligence of the crowd, or in other words, intelligence of a large, random collective, exists mostly in social media platforms such as twitter. The collective does not comprise (at least not necessarily) experts on crises, just regular people mostly. Nevertheless, there is valuable intelligence to…

Promotor: F.H.J. Redig, Co-Promotor: W.T.F. den Hollander

We are aiming to develop novel technologies to allow better sample preparation or coupling of analytical methods to (i) analyse ultra small samples, (ii) to analyse more metabolites in a quantitative manner and/or (iii) increase the sample throughput.

This thesis examines silicon pore optics (SPO), a technology that exploits silicon wafers from the semiconductor industry to create extremely high quality X-ray optics, by studying its manufacturing process, applications, and prospects.

Molecular complexes can be used as electrocatalysts for oxygen reduction, water oxidation, and/or hydrogen peroxide production.

We are developing biology-driven platforms to measure metabolites based on liquid chromatography-mass spectrometry (LC-MS), gas chromatography-MS (GC-MS), and capillary electrophoresis-MS (CE-MS).

This thesis describes the synthesis and biological evaluation of TLR2/6, TLR4, TLR7/8 and TLR9 ligands, of which the activity can be conditionally controlled.

FAIRDOM consortium is an open initiative of various partners including funding programmes, large-consortia, institutes, small groups as well as individuals.

PURPOSE: To determine the effect of elasticity on the skin permeation of ketoprofen from surfactant-based vesicular formulations and elastic liposomes.

New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.

PhD candidate Lilo Nein investigates relations between texts and performances from the perspective of visual art.

This is a study of Plateau Shimakonde, a sub-dialect of the Makonde language which is spoken on the Makonde Plateau in northern Mozambique.