121 search results for “antimicrobi C3 ABle stoffen” in the Public website
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Finding and valorizing new antibiotics using AI
Antibiotics are a class of medicine most people take for granted. But pathogenic bacteria are becoming more and more resistant to our antibiotics, and this poses a great challenge for future treatments. There is thus a great societal need to identify new molecules that can address new targets and be…
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Overview
The Division of Systems Pharmacology and Pharmacy (SPP) aims to develop precision medicine approaches to characterise and predict variation in treatment response and enhance translational drug development strategies.
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Media attention inaugural lecture ecotoxicologist Martina Vijver
Time and again synthesised substances have been shown to pollute the environment more than lab tests predicted. In her inaugural lecture on 16 November, professor of Ecotoxicology Martina Vijver gives a warning for the risks of new, man-made chemical substances and nanomaterials. Various media payed…
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Plant Macro-Fossils and Climate Change
This part of the research programme is carried out by Prof. Dr. René Cappers. It focusses on the continuities and changes in the use of plants at Late Neolithic Tell Sabi Abyad, as well as on their implications as proxy evidence for the climate change c. 6200 BC. Parallel to the design of the other…
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Unwiring beneficial functions and regulatory networks in the plant endosphere
How do plants lure microscopically small 'support teams' into their roots for protection against diseases? And what functions are activated in the microbes and the plants?
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Bioactive Molecules in Plant Sciences
Plant Sciences' contribution to the Bioactive Molecules research theme is to identify new plant bioactive molecules, and unravel their mechanisms of action in plant development or health, and the regulatory networks and (bio)synthetic pathways required for their production.
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MARBLES - Marine Biodiversity as Sustainable Resource of Disease-Suppressive Microbes and Bioprotectants for Aquaculture and Crop Diseases
To explore the potential of marine microorganisms as producers of novel antimicrobial agents and as bioprotectants in aqua- and agriculture, using an integrative, ecology-based strategy for bioprospecting.
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From stress to success: how actinobacteria exploit life without a cell wall
The central question of this Vici proposal is to investigate if, and how actinobacteria exploit life without a cell wall.
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COMMUNITY: unraveling the regulatory networks in Streptomyces that switch on antibiotic production on demand
Through his project we will unravel the global regulatory networks that control gene expression in Streptomyces bacteria and allow them to properly respond to major changes in the environment; we will then harness this knowledge to activate and identify novel antibiotics
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Student projects
Are you looking for a research project?
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Young transgender people are able to decide about puberty blockers
Young transgender people are able to decide together with their parents on a reversible intervention with puberty blockers. These are the results of a study by LUMC Curium and Amsterdam UMC of 74 young people undergoing treatment. Ninety percent of the young people studied proved able to make an informed…
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Jonique van Hooff: 'I love being able to work independently'.
Between the humanities Dean Mark Rutgers and his busy schedule we can find board secretary Jonique van Hooff. Her task is to make sure that the Dean gets to smoothly do his job. 'I get very happy when, after trying to figure things out with busy schedules, I manage to properly arrange things.'
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ENW grant from the Dutch Research Council (NWO), Oct.30 2023
“Is it possible to restore antibiotic sensitivity in resistant bacteria?” Dr. Tingjie Guo wondered. “Watch me and learn”, phage responded. Dr. Tingjie Guo received an open competition XS domain ENW grant from the Dutch Research Council (NWO) to investigate the evolutionary trade-off of antimicrobial…
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Hit Discovery
The goal of hit discovery is to identify suitable chemical starting points to modulate a drug target. A hit can be, a.o., a small molecule, a protein or mRNA. Hit identification is performed via rational design, genome mining, (targeted) library screening, or in silico approaches.
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Animal Sciences
We perform multidisciplinary research at molecular, cellular, and organismal levels of animal biology to increase fundamental understanding of health and disease.
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Key publications
Key publications of the Quantitative Pharmacology group
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LED3 Drug Discovery Case Studies
To get a feeling of how we operate at LED3 when it comes to Early Drug Discovery, please browse through our case studies. When you select a case study you’ll find relevant contacts.
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2024
Elk jaar organiseert het LIBC in samenwerking met de gemeente Leiden een Publieksdag over hersenonderzoek.
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This week the National Antibiotic Development Platform, NADP, was officially launched via a meeting in Utrecht.
Antibiotic resistance is one of the major threats to human health. This week the National Antibiotic Development Platform, NADP, was officially launched via a meeting in Utrecht, with many of the stakeholders in the field present.
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Leiden University joins the Just Transitions for AMR Working Group
Leiden University joins the Just Transitions for AMR Working Group, an interdisciplinary team of social science and humanities researchers who are exploring ways to mitigate the growing threat of antimicrobial resistance in a just and equitable manner, with due consideration to the human rights of present…
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‘Citizens should be able to rely on information provided by Tax and Customs Administration’
Information provided by the Tax and Customs Administration is something that concerns every citizen. So it is not surprising that the Tax hotline receives around 10 million calls each year. The Benefits Affair emphasised the citizen’s perspective in communications with the Tax and Customs Administration.…
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Daan Weggemans in NRC: Locked-up terrorists should be able to earn an income
The Dutch Department of Justice will give imprisoned terrorists the opportunity to earn money. This should have an positive effect on the resocialisation of detainees.
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Career prospects
With a MSc in LST you are well prepared for a wide range of career opportunities. Life Science research and business is one of the fastest growing economic activities worldwide.
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Being able to host international organisations by taking that extra step
The number of international organisations has increased over the last decades. As has the number of cities interested in housing these organisations. International organisations bring wealth to cities and help improve their reputation. They often act as a magnet for other international corporations.…
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Is the Netherlands able to cope with a cyber-attack from Russia? Live on BNR news radio
On the 15th of March, the radio program “The World of BNR Nieuwsradio” was live broadcasted from the Spanish Steps at the Faculty of Governance and Global Affairs in The Hague. Jaap de Hoop Scheffer, associated with the Institute of Security and Global Affairs, was one of the radio show’s guests. Following…
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Researchers debunk earlier study: babies may not be able to learn language rules after all
For two decades, language experts were certain that babies were able to learn language rules from as young as the age of seven months. However, recent research carried out by a consortium of four Dutch baby labs led by researchers from Leiden cast doubts on this certainty. We spoke to researchers Andreea…
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The bite that heals: New antibiotics with help from venomous animals
Prof. Gilles van Wezel and Prof. Mike Richardson of the Institute of Biology Leiden received €1.4 million to find new antibiotics.
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New STW-grant to redirect the plant micro biome: “Back to the Roots”
Professors Jos Raaijmakers (NIOO) and Gilles Van Wezel (IBL) received an STW Perspectief- grant of €3 million from the Dutch Technology Foundation and several supporting companies.
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Nathaniel Martin new IBL professor in Bioorganic Chemistry
Nathaniel Martin has been appointed professor in the field of Bioorganic Chemistry within the Faculty of Science at the Institute of Biology Leiden, starting from 1 March 2018. His research focuses on using new (bio)chemical approaches to combat infectious disease, as well as on developing new molecular…
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Leiden University and LUMC join Netherlands Centre for One Health
Leiden University and Leiden University Medical Center have joined the Netherlands Centre for One Health (NCOH), further strengthening the academic network in which such problems as antimicrobial resistance are studied.
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master’s thesis to scientific article: ‘Really strange that people are able to quote me now’
Vivian van der Linde completed her masters Crisis & Security Management in the summer of 2020 by writing a thesis on Dieselgate. Freshly graduated, she felt she wanted to do more with her research. But how do you go about that, having just finished studying? Together with her thesis supervisor Wouter Jong…
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One last time 'AskBetty': 'The best part was being able to teach people something'
Betty de Jonge is a household name in our faculty. As the person behind AskBetty, she knew how to answer every question about Office. Starting this month, she has officially retired.
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The EPIC Alliance joins forces to combat antibiotic resistance
No, this isn’t about a Star Wars Alliance that wants to suppress The Resistance. Rather, the EPIC Alliance brings together scientific experts from seven countries to address the growing threat of antibiotic resistance. Leiden professor Nathaniel Martin is part of the 11-member consortium.
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What if superbugs were as tall as buildings?
In Sci-Fi comic book Resist NOW!, wondrous adventures will illustrate possibilities to combat antimicrobial resistance. But the comic book will only be produced if enough money is raised to make the project into reality.
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Quantitative paleodietary reconstruction with complex foodwebs: An isotopic case study from the Caribbean
William Pestle and Jason Laffoon recently published a new article entitled 'Quantitative paleodietary reconstruction with complex foodwebs: An isotopic case study from the Caribbean' in the Journal of Archaeological Science: Reports.
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One thesis research project: two articles and a fact sheet: 'I was able to get so much more out of my thesis'
How do you turn your thesis into an academic article? That's a question Floortje Fontein, who conducted research into inclusive leadership, can answer. She looked at how public managers manage a diverse team. She got a 9 for her thesis and is currently working on several articles based on the results…
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Six million boost to search for new antibiotics
Edith Schippers, Minister of Health, will be investing six million euros over the coming four years to boost research on new antibiotics. The programme will be set up by several different parties, including the Leiden Centre for Antimicrobial Research.
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Development of kinase inhibitors and activity-based probes
Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt
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Snake venom glands grown in lab
For the first time, researchers were able to grow organoids from snake venom glands. The lab-grown 3-D structures can produce snake venom molecules. This is a major step in finding treatments to tackle snakebite, which causes over 100,000 deaths each year. Publication in top journal Cell.
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Reports
Overview of the CML reports
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Lucien van Beek receives LUF grant: 'It is a great feeling to be able to work on my ideas'
University lecturer Lucien van Beek has been awarded a LUF Praesidium Libertatis Grant. He will use the sum of 75,000 euros to research the thinking of people in ancient and prehistoric times. To do that, he will look for unusual or striking metaphors in the earliest Indo-European languages.
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Localising global garment biographies
Discover the effects of clothing value and lifespan on buyer-user-producer relationships through collaborative research with Localising Global Garment Biographies.
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Goede redenen voor foute taal: Een open symposium over taalregels in het brein en in de maatschappij
Foute taal? Bestaat niet!
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Macrophages as drivers of an opportunistic infection
The opportunistic bacterium Burkholderia cenocepacia is feared by cystic fibrosis patients and is emerging in hospital-acquired infections. An international study sheds new light on the infection mechanism of this opportunistic pathogen that may have large implications for treatment strategies.
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NWO grant gives way to more sustainable production of antibiotics
The opportunity to explore a new, exciting research topic. That is how Lennart Schada von Borzyskowski describes his successful application for the NWO XS grant. It comprises 50,000 euros, which the researcher from the Institute of Biology Leiden (IBL) will spend on investigating a more sustainable…
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Rock art research at Qurta
Dirk Huyge (Director) & Wouter Claes (Vice-Director)
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What do complex molecules tell us about star formation?
How do you progress from an immense gas cloud somewhere in the universe to a star with planets? Research by Astronomy PhD student Martijn van Gelder sheds more light on the earliest phases of this process. He will receive his doctorate on November 24th.
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New Scientific Director for the Institute of Biology Leiden
Gilles van Wezel has been appointed the new Scientific Director of the Institute of Biology Leiden starting September 1st, 2018. Van Wezel succeeds Herman Spaink, who has been the Scientific Director since September 2014.
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Consortia awarded grant for research into pressing issues
Various consortia in which Leiden University is represented are beginning interdisciplinary research, which will bring scientific and societal breakthroughs within reach. Knowledge institutions, government and private parties are working closely together on the projects.
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Expanding Social Sciences & Humanities in African Global Health Discourse
LUNHA strives to redefine global health by prioritizing justice, fairness, and inclusion in Africa. Through collaboration with diverse stakeholders, LUNHA aims to reshape global health research and foster a broader engagement with social sciences and humanities.