Wat zijn de gevolgen van maatschappelijke trends zoals vergrijzing, individualisering en internationalisering voor regelgeving en instituties op het terrein van sociale zekerheid, pensioenen en de arbeidsmarkt?

Ontdek de actualiteitencursus Europese Regelgeving Artificial Intelligence en word in één dag expert van Europese AI-regelgeving. Lees hier meer!

Obesity may alter how a person absorbs, distributes, metabolizes or excretes medication. This thesis describes how obesity affects drug levels in the blood for antimicrobial agents, such as ciprofloxacin and fluconazole.

Promotor: Prof.dr. E. Bouwman, Co-promotor: S. Bonnet

Systems with local constraints is a new finding in recent researches on complex systems. The heterogeneous spatial interactions and the temporal dependencies among those numerous units make it difficult to describe by traditional statistical physics.

Promotor: A. Achúcarro Co-promotor: A. Boyarsky

In populations with a seed-bank, individuals can temporarily become dormant and refrain from reproduction until they can become active again. The repository of all dormant individuals in the population is called the seed-bank. Seed-banks are observed in many taxa, including plants, bacteria and other…

Promotors: C.A.J. Knibbe, Anthonius de Boer, Co-promotor: M.M.J. van der Vorst

Radio jets are important to the evoultion of galaxies. However, it is still not fully understood how a radio jet can be triggered.

In this work, I explore the creation of new methods that optimize simulations of the gravitational N-body problem. Specifically, I take advantage of the recent popularity of Machine Learning methods to find tools that can suit this problem.

This thesis develops a method for direction dependent calibration of the ionosphere in radio interferometric data.

Op 10 november 2021 verdedigde Carmel van Niekerk-Jacobs het proefschrift 'Realising the right to reproduce with assistance in South Africa'. Het promotieonderzoek is begeleid door prof.dr. J.J. Sloth-Nielsen en prof.dr. T. Liefaard.

Molecular materials have been a subject of interest in fundamental research and applications for decades, and have been studied as bulk crystals, (thin) films and as individual molecules, due to the large variety in their properties. This dissertation explores pentacene crystals near the two-dimensional…

Electron microscopy has become an extremely important techniquein a wide variety of elds.

Promotor: Prof.dr. D. Bouwmeester

Promotor: S.J. Edixhoven, A. Iovita

CONCLUSION: This study demonstrates that human macrophages can be induced to exert direct anti-tumor activity against osteosarcoma cells. Our observation that the induction of macrophage anti-tumor activity by L-MTP-PE required IFN-gamma may be of relevance for the optimization of L-MTP-PE therapy in…

This thesis focuses on the application of lipid-based nanomedicine in drug delivery, including small molecular antitumor drugs and biomacromolecules including mRNA, and evaluates their biological performance.

Promotor: F.S. de Boer, Co-promotor: M.M. Bonsangue

Promotor: Prof.dr. D. Bouwmeester, Co-Promotor: M.J.A. de Dood

In recent decades, climate change has led to more frequent and severe drought events, causing serious consequences such as increased forest mortality and significant crop yield losses. Understanding how drought affects plants, especially economically important herbaceous species, is crucial for predicting…

In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.

CrO2, a half-metal ferromagnet, has shown great promise for superconducting spintronics applications for nearly two decades.

With the rise of multi-drug resistant bacterial pathogens, the possibility of a post-antibiotic world is quickly becoming reality.

We are living in an information era where the amount of image and video data increases exponentially.

The ultimate goal of cosmologists is to find a cosmological model able to explain the current observational data.

Promotores: R. Tijdeman, K.J. Batenburg

The database research community has made tremendous strides in developing powerful database engines that allow for efficient analytical query processing.

Until the 1990s, the only known planets were those in our Solar System. Three decades later, several thousand exoplanets have been discovered orbiting stars other than the Sun, and substantial efforts have been made to explore these strange new worlds through spectroscopic analyses of their atmosphe…

Promotor: S.M. Verduyn Lunel, Co-promotoren: M.F.E. de Jeu, S.D. Silvestrov

To limit the effects of climate change, global average temperature since pre-industrial measurements are to be kept well below 2 °C preferably even at 1.5 °C.

This thesis is a collection of theoretical works aiming at adjusting quantum algorithms to the hardware of quantum computers.

OB associations are loose groups of young, massive stars. They constitute the last stage of the massive starformation process, and the context in which new stars are formed.

The focus of this thesis is how stars like our Sun and planets like Jupiter, Saturn, and Earth are formed.

The progressive loss and degeneration of dopaminergic neurons is a major pathological hallmark of Parkinson's disease (PD). The onset and progression of PD can be triggered by multiple risk factors, for instance, genetic mutation, environmental exposure, and aging.

Metal complexes and 2D materials like graphene were combined to produce structures that can function as sensors.

Almost three years after receiving her honorary doctorate, Dr Graça Machel returned to Leiden University. Over the course of two days she spoke with students, researchers, and other interested persons, about human rights – particularly those of women and children – in a world in which these are continually…

Promotor: W.Th.F. den Hollander, Co-promotor: F.R. Nardi

Een virtuele hand die voelt alsof het je eigen hand is. Je vrolijker voelen omdat een virtueel gezicht samen met jou glimlacht. Psycholoog Ke Ma ontdekte met virtual reality dat ons lichaamsgevoel flexibeler is dan gedacht. Ke Ma: ‘We kunnen fantastische applicaties bedenken.’

We explored the Universe using weak gravitational lensing, a phenomenon that occurs when light from distant galaxies is bent by the gravitational fields of closer cosmic objects, much like how a lens distorts light.

Promotor: S.J. Edixhoven

In this thesis we examine certain phenomena in symplectic topology which are related to the theory of isolated singularities.

In vitro disease models play a fundamental role in drug research. They enable the systemic identification and validation of disease mechanisms and the discovery of possible drug targets. However, more than often, drug candidates that are identified in vitro fail in the later clinical stages of drug…

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Promotor: Prof.dr. M. de Jong, Co-Promotor: A.J. Heijboer

In dit proefschrift wordt gekeken naar de produktie en consumptie van het reality-tv-programma ‘Nieuwe Wijze Oom’. Deze show, uitgezonden op het entertainmentkanaal van de provincie Shanghai, draait om mediation in conflicten tussen burgers. ‘Nieuwe Wijze Oom’ is geliefd bij het publiek én bij de autoriteiten.…

Improvements of weak gravitational lensing shape measurements are presented and some used for data analysis.

Op 8 oktober 2020 verdedigde Kartica van der Zon haar proefschrift 'Pleegrechten voor kinderen'. Het promotieonderzoek is begeleid door promotoren prof.mr. M.R. Bruning en prof.dr.mr. T. Liefaard.

Anthropogenic noise negatively affects wildlife in a wide range of taxonomic groups.

Materials with strongly correlated electrons show some of the most mysterious and exotic phases of quantum matter, such as unconventional superconductivity, quantum criticality and strange metal phase.