Promotores: C.A.J. Knibbe, D. Tibboel, Co-Promotor: P. Bruins

Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang

Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen

In this thesis, two potential therapeutic targets for diabetic nephropathy were dentified and investigated. First, we show that glomerular clusterin is upregulated in diabetic nephropathy and demonstrated that recombinant clusterin protein can protect the podocytes against oxidative stress in vitro.…

Op 1 juli 2020 verdedigde Niek Strohmaier zijn proefschrift 'Making Sense of Business Failure'. Het promotieonderzoek is begeleid door promotoren prof.dr. J.A.A. Adriaanse en dr. H. Pluut.

Dr. Nikki Ikani daagt de binaire visies op inlichtingenwaarschuwingen uit en stelt een typologie voor om de effectiviteit van waarschuwingen te evalueren.

Promotor: Prof.dr. M. Danhof, Co-promotor: O.E. Della Pasqua

Our modern society thrives on chemicals, and demand is only growing with novel chemicals being introduced onto the market. However, with increasing demand, so come potentially increasing ecological consequences of these man-made chemicals.

Promotor: Prof.dr. M. Danhof

Nierfalen is een serieus probleem omdat nieren zichzelf niet kunnen regenereren na ernstige beschadiging. Een mogelijke oplossing bestaat uit het kunstmatig laten groeien van gezond nierweefsel. Daarvoor moeten wetenschappers eerst de ontwikkeling begrijpen tijdens de allereerste fase, in de foetus.…

The aims of the project are to: further clarify 'inhibition by safety'; explore and describe all possible sagety factors, with a special focus on the primary human safety source: social connectedness; reviewing prolonged stress responses without stressors.

Promotie

Promotor: S.M. Verduyn Lunel

Heart failure is a major health care problem with high mortality.

Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken

The last decades it is increasingly recognized that acute as well as chronic postoperative pain is an important problem. Treatment and prevention of postoperative pain is a challenge, especially in special patient populations where there is only limited guidance on how to optimally use opioids.

A New Technology-Based Firm (NTBF) is a significant enabler of job creation and a driver of the economy through stimulating innovation.

Promotor: G.J.B. van Ommen

Hoe meer we leren over een (neuro-)psychologische of lichamelijke aandoening en de hieraan gerelateerde gedragsfactoren, hoe beter we deze niet alleen kunnen signaleren, maar ook behandelen. Het is dus belangrijk dat recente inzichten over (neuro-)psychologische problemen en daaraan gerelateerde gedragsfactoren…

In this top-rated course, you will learn how the European Union prepares and decides on policy, and how policy is transferred to member states and implemented by various authorities. It discusses the challenges of the European multi-level governance structure and the main causes of policy failure or…

The impact of the phenotypic plasticity of P. aeruginosa and the distinct CF lung microenvironments on antibiotic drug effects and resistance remains poorly understood.

Somatische symptomen, zoals pijn, jeuk en vermoeidheid, blijken in twee richtingen samen te hangen met psychische symptomen. Hoewel acute somatische symptomen bepaalde adaptieve eigenschappen hebben, kunnen chronische symptomen in plaats daarvan leiden tot verstoring van dagelijkse activiteiten en vermindering…

Het laatste nieuws over diversiteit en inclusie binnen de Universiteit Leiden en een overzicht van komende activiteiten

Cardiovascular diseases are still a major concern for the global health.

Hoe kunnen nierpatiënten geholpen worden een gezonde leefstijl aan te nemen? Gezondheidspsycholoog Sandra van Dijk gaat dit onderzoeken met een persoonsgebonden subsidie van de Nierstichting.

Errors are everywhere, and mechanical failures are especially common: buckled grain silos and cracked support columns are, justly, seen as an issue to be avoided.

Search and conversational systems have become central to how people access information and perform tasks.

Aangezien jeuk en pijn zeer belastend kunnen zijn, vooral wanneer mensen chronisch aan (een van) deze symptomen lijden, is het belangrijk te weten door welke factoren deze gewaarwordingen worden beïnvloed. Het wordt steeds duidelijker dat psychologische factoren een belangrijke rol spelen bij het ervaren…

Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.

Cardiovascular syndromes are the major cause of death in Western societies.

Promotor: W. Jiskoot, Co-promotor: A. Hawe

Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik

Promotor: Prof.dr. B. van de Water

Atherosclerosis is the most prominent underlying pathology of cardiovascular disease and an important cause of major adverse cardiovascular events.

Promotores: Prof.dr. J. Kuiper, Prof.dr. P.H.A. Quax, Co-promotor: I. Bot

Promotor: Johan Kuiper, Co-promotor: Saskia C.A. de Jager

Cardiovascular disease is the leading cause of death worldwide.

Promotor: Prof.dr. J. Kuiper

Schistosomiasis is an acute and chronic disease caused by blood dwelling parasitic trematodes of the genus Schistosoma, and it is classified as the second most socioeconomically devastating parasitic disease, second only to malaria.

This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).

Fungal infections pose a significant threat to individuals with compromised immune systems and despite advancements in diagnosis and treatment, they continue to jeopardize patient’s health.

Promotor: C.A.J. Knibbe, Co-promotor: J.J. Boelens, R.G.M. Bredius

Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.

Developing new medicines is one of modern science's most significant hurdles, a process marked by high costs, long timelines, and frequent failures of promising candidates.

Promotor: G.R. de Snoo

Obesity may alter how a person absorbs, distributes, metabolizes or excretes medication. This thesis describes how obesity affects drug levels in the blood for antimicrobial agents, such as ciprofloxacin and fluconazole.