Promotor: J.N. Kok, Co-Promotor: A.J. Knobbe

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In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.

In this thesis, we extend the concept of null models as canonical ensembles of multi-graphs with given constraints and present new metrics able to characterize real-world layered systems based on their correlation patterns.

All crested and marbled newts (the genus Triturus) suffer from an unusual genetic abnormality, called a balanced lethal system, that kills exactly half of their offspring. How can a trait so disadvantageous have survived millions of years of natural selection?

Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.

Systems with local constraints is a new finding in recent researches on complex systems. The heterogeneous spatial interactions and the temporal dependencies among those numerous units make it difficult to describe by traditional statistical physics.

This dissertation is part of a broader research project that revolves around unraveling the evolution of balanced lethal systems.

Promotor: Prof.dr. J. Kuiper

For many system in statistical physics the microcanonical and canonical ensemble are equivalent in the thermodynamic limit, but not for all.

Promotor: Prof.dr. L.J. Slikkerveer

Promotor: S.M. Verduyn Lunel

According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).

Stars like the sun are born in large molecular clouds existing from gas and dust. During the formation process, the chemical composition of the material can be altered drastically by the changing physical conditions.

Promotor: Prof.dr. M. Danhof

This study has been carried out in the community of Sukamiskin, a kelurahan (‘village’) in Bandung, the Capital of West Java Province, located in the Sunda Region of Indonesia.

Promotor: C. W. J. Beenakker, Co-promotor: J. K. Asboth

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

Dynamical systems describe the evolution of objects in a space over time and may be used to model physical phenomena. Due to this, much research is dedicated to understanding the mathematics of dynamical systems.

This thesis tackles the difficulty of predicting the liver’s clinical response to novel therapies, a challenge arising from interspecies differences and limitations of existing in vitro models.

Systems are called real-time systems, if the correctness of the system does not only depend on the correctness of the system output but also on whether the output is delivered on time.

Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik

Het doel van het onderzoeksprogramma Systems Pharmacology ligt in de ontwikkeling van strategieën voor gepersonaliseerde geneesmiddelen en de ontwikkeling van nieuwe systeemgebaseerde benaderingen in de translationele en klinische farmacologie.

We have studied the impact of particle shape anisotropy, multivalent interactions and flexibility on systems of micron-sized colloidal particles.

Adenosine is an endogenous ligand which exerts its action by activating adenosine receptors (ARs), while its circulating levels are controlled via a variety of mechanism and proteins, amongst others the equilibrative nucleoside transporters (ENTs).

Gold nanorods are biocompatible nanoparticles that present an excellent two-photon signal that can be used to get high spatial resolution inside living cells. Gold nanorods are photostable and therefore can be followed inside cells for long time, with possible applications as trackers in live cells.

In this thesis I describe the results of Pulsed Interleaved Excitation and Fluorescence (Cross) Correlation Spectroscopy (PIE-F(C)CS) combined with single-pair Förster Resonance Energy Transfer (spFRET) used to study dynamics in single nucleosomes, which depends on subtle differences in the length of…

This thesis describes the genetic and prokaryotic diversity of giant barrel sponges.

Promotor: A. Doelman, Co-promotores: P.J.A. van Heijster; A. Zagaris

This thesis explores how electron paramagnetic resonance (EPR) spectroscopy can be used to investigate key biochemical processes.

Promotor: Arjen Doelman, Co-promotor: Vivi Rottschäfer

In this thesis, we show that we can use Shimura’s CM theory to explicitly compute the Hilbert class field of any primitive quartic CM field.

This dissertation aims to advance understanding of amoeboid single cell migration under the influence of changing physicochemical environmental properties. The particular focus is on the relatively unknown influence of differing physical properties in the extracellular environment, such as the migratory…

In the traditional theory of linear elasticity, superposition dictates that the response of a material does not depend on the sequence of the applied mechanical actuations.

This thesis provides explicit expressions for the density functions of absolutely continuous invariant measures for general families of interval maps, that include random maps and infinite measure transformations, not necessarily number systems.

Het onderzoek van dit programma is gecentreerd rond dynamische systemen, functionele analyse en hun interactie.

Promotor: A. Doelman, Co-promotor: J.D.M. Rademacher

Het Computer Systems, Imagery & Media (CSI) onderzoeksprogramma voert fundamenteel onderzoek uit naar methoden en technieken voor het ontwerp, de implementatie en de applicatie van geavanceerde computersystemen.

This thesis studies operator-algebraic aspects of subproduct systems, a generalization of product systems of Hilbert spaces.

In condensed matter systems electron-electron interactions, negligible in everyday metals, can dramatically alter the electronic behavior of the system. Examples of such altered behavior include high-temperature superconductivity and modulation of the electron density.

Immunotherapies for cancer are an emerging class of therapeutic strategies which aim to treat cancer via augmentation of the immune system.

Thermodynamics is one of the founding scientific pillars that has helped us better understand heat engines, biology, ecosystems, and even black holes. While it fundamentally describes large systems by examining the bulk behavior of their constituents, it is anchored in the statistical equivalence of…

Protein–protein complexes are formed via transient states called encounter complexes that greatly influence the formation of the stereospecific complex.

We use DNA strands to stabilize few-atom silver clusters, which show unique optical and chemical properties. This thesis involves the study of these constructs for various applications.

Promotor: M.A.G.J. Orrit

Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen

Promotor: Prof.dr. M. Ubbink

This thesis seeks to combine two different research topics; Multi-Objective Optimization and Complex Network Analysis.

Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.