Co-creatie en multidisciplinair leren over grenzen heen.

In this thesis, we have used numerical approaches to study the effects of translational symmetry breaking on strange metallic systems as realised by the holographic duality⁠.

Thesis focused on uncovering the underlying mechanisms of the lysosomal storage disorders Gaucher's disease using chemical tools, biochemical assays and lipidomics.

This thesis is devoted to an in-depth examination of the various effects of disorder in the cuprate high-temperature superconductors.

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Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.

Until the 1990s, the only known planets were those in our Solar System. Three decades later, several thousand exoplanets have been discovered orbiting stars other than the Sun, and substantial efforts have been made to explore these strange new worlds through spectroscopic analyses of their atmosphe…

Lysosomal glycosidases are acid hydrolases that fragment glycoconjugates in lysosomes.

Neurodegenerative diseases pose a large medical and societal challenge. The etiology of these diseases is still poorly understood, which makes drug discovery for these diseases difficult.

The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.

Advanced mass spectrometry of glycosphingolipids takes the central stage in this thesis. Investigations focus on characterization of glycosphingolipid metabolism in health and disease with emphasis to the detection and accurate quantitation of known and so far unknown glycosphingolipids and closely…

Emoties en de psychosociale ontwikkeling van kinderen met en zonder Taal Ontwikkelingsstoornis

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-promotor: B.I. Florea

The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.

N-acylethanolamines (NAEs), including N-arachidonoylethanolamine (anandamide, AEA), N-palmitoylethanolamine (PEA) and N-oleoylethanolamine (OEA), are signaling lipids that play an important role in different physiological process.

What physics controls the properties of quantum matter, such as how electrons flow inside high-temperature superconductors? This question has captivated the physics community and industry for decades, in part due to the great technological potential such materials have, but also because they have resisted…

The studies described in this thesis deal with glycosidases, in particular alpha-galactosidases.

Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.

The main aim of my Ph.D. thesis is to further explore the value of using early developing zebrafish larvae (up to 5 dpf) as a model to study anxiety-like behaviour and their pharmacological modulation with drugs.

Gaucher disease is a rare metabolic disorder, in which a mutation of the enzyme glucocerebrosidase (GBA1) causes buildup of its substrate glucosylceramide and the deacylated counterpart glucosylsphingosine in lysosomes.

Promotor: Prof.dr. C.W.J. Beenakker

The research described in this thesis has, using the zebrafish as a model system, shed new light on the intricate relationship between TB and DM2, in particular on the role of leptin, SHP-1 and glucocorticoids.

The ideas underlying this thesis are that lipidomics may improve the diagnosis of liver metabolic diseases, and can provide further insights into the underlying pathophysiology of these diseases.

Optimalisatie, werkingsmechanismen en voorspellers van het resultaat van lichttherapie bij depressie: Een multicenter gerandomiseerde trial

This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).

The research described in this thesis centered on retaining exo-β-glucosidases implicated in health and disease, in particular the human inherited lysosomal storage disorder, Gaucher disease (GD).

The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…

This Thesis describes the design, synthesis and evaluation as glycoprocessing enzyme inhibitors of focused libraries of iminosugars.

De Leiden Teachers’ Academy (LTA) wil de kwaliteiten van onze beste docenten zichtbaar maken, verder ontwikkelen en universiteitsbreed benutten. De LTA bestaat uit 26 Teaching Fellows, die alle een passie voor onderwijs hebben.

Samen met wetenschappers van over de hele wereld streeft de ENIGMA-Anxiety Werkgroep ernaar om meer inzicht te krijgen in de neurobiologische karakteristieken van angststoornissen.

In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.

Control of infectious diseases poses continuous challenges for human health.

The effective treatment of tuberculosis (TB) remains a major challenge to global health.

Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency

Tijdens de Leiden Science Family Day worden er vijf lezingen gegeven: twee kinderlezingen en drie lezingen voor volwassenen. Ben jij er bij?

Een lijst met wetenschappelijke publicaties samengesteld door het team van het TRIXY Expertisecentrum.

A neurocognitive investigation of the development of social performance monitoring in youth growing up in stressful versus non-stressful environments

Promotor: Prof.dr. J. den Hertog

Het Dappere Kleintjes onderzoeksteam heeft al meerdere artikelen gepubliceerd over angst en verlegenheid in jonge kinderen.

Ongewenste associaties met seks kunnen afgeleerd worden, maar terugkeren als de omstandigheden veranderen. Daarom moet het afleren in diverse situaties plaatsvinden. Het geneesmiddel D-cycloserine biedt mogelijk uitkomst. Dat ontdekte psychologe Mirte Brom.

Materials with strongly correlated electrons show some of the most mysterious and exotic phases of quantum matter, such as unconventional superconductivity, quantum criticality and strange metal phase.

Elk jaar reikt het Leids Universitair Studentenplatform (LUS) de Leidse Onderwijsprijs uit.

Cool Little Kids is een onderzoeksproject ter preventie van angstproblemen bij verlegen en teruggetrokken kinderen van 3-6 jaar die extreem verlegen of angstig zijn.

Studying the impact of urbanisation on the respiratory health of past Dutch populations (1200-1850 CE).

Despite substantial progress in understanding tuberculosis (TB), the eradication of the TB epidemic is still far from reach.

Glycosidases are important enzymes in the turnover of polysaccharides and glycoconjugates, and are involved in a range of human pathologies including genetic disorders such as Gaucher and Pompe disease, but also in various cancers.