This thesis describes how different colours of light affect various aspects of the growth and development of Arabidopsis and tomato plants⁠.

Onderzoekers van het LUMC hebben, in samenwerking met de TU Delft, een manier gevonden om een op hol geslagen hart, automatisch en direct te resetten met een geïmplanteerd LED-lampje.

Door niet samen te werken met buureilanden blijft Sint Eustatius gevangen in de relatie met Nederland, betoogt de Leidse politicoloog Wouter Veenendaal in de Volkskrant.

Luuk de Ligt heeft met zijn projectvoorstel 'An Empire of 2000 cities: urban networks and economic integration in the Roman Empire' een prestigieuze ERC Advanced Grant binnengehaald. Het project, dat in 2013 van start zal gaan, gaat plaats bieden aan in ieder geval zes aio's en twee postdocs.

The energy system is at the heart of two of the greatest challenges of the 21st century: decreasing CO2 emissions to meet the ambitions of the Paris agreement while fulfilling the growing energy demand associated with the economic aspirations of a growing world population.

This thesis focuses on the social dimensions of crane and wetland conservation in rural landscapes in Kenya, Uganda and Zimbabwe.

The investigations described in this thesis lay out strategies aimed at advancing antibiotic research and development. The examples presented revolve around two main approaches: understanding drug-target interactions and target identification.

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof.dr. A.H. Meijer

The thesis explores how interstellar chemistry evolves as a function of time and changing physical architectures during the formation of stars.

This study has been carried out in the community of Sukamiskin, a kelurahan (‘village’) in Bandung, the Capital of West Java Province, located in the Sunda Region of Indonesia.

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Endocannabinoids are lipid messengers that modulate various physiological functions by activating the cannabinoid CB1 and CB2 receptors. While the metabolism of endocannabinoids and their action at the CB receptors is fairly well studied, the molecular mechanisms governing their release and transport…

Promotor: Erik F. Smets, Co-promotores: Barbara Gravendeel, Niels Raes

Tijdens de ontwikkeling van de Humanities Campus komen veel aspecten van duurzaamheid samen. Denk bijvoorbeeld aan:

The main theme of this thesis is the theoretical study of Gaussian processes as a tool in Bayesian nonparametric statistics.

There are many interpretations of quantum mechanics, and ultimately experiments are needed to verify or falsify these interpretations.

Geometric phases lead to a nontrivial interference result when an electron's different quantum mechanical paths choices encircle a magnetic coil in an Aharonov-Bohm experiment.

Microbiome composition of the spermosphere and the rhizosphere of wild and modern bean accessions grown in an agricultural and a native soil from Colombia was characterized by metagenomics and cultivation-dependent approaches.

Plant-microbe interaction resulted in different physio/chemical responses by host plant and interacting rhizobacteria.

The spindle-assembly checkpoint (SAC) is a safety mechanism which secures accurate chromosome segregation during mitosis.

Increasing the efficiency of gene targeting (GT) as a genome editing tool in plants has been an important goal in plant biotechnology.

Large carnivore population is globally declining as a result of the fragmentation of habitat, large prey depletion and retaliatory killing by pastoralists.

Promotor: Prof.dr. I.A.G. Snellen, C.U. Keller

Inspired by natural photosynthesis, perovskite-based photoelectrochemical (PEC) systems are being developed for artificial photosynthesis, aiming to enhance solar-to-hydrogen conversion for green energy.

Balsaminaceae is a diverse plant family characterized by a huge floral morphological diversity.

Promotor: J.G.E.M. Fraaije, Co-Promotor: A. Kros

Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…

Promotor: J.M. van Ruitenbeek, Co-Promotor: S.J. van der Molen

The focus of this thesis is how stars like our Sun and planets like Jupiter, Saturn, and Earth are formed.

Promotor: A.P. IJzerman

This dissertation presents the results of the importance of creativity for ICT-students of Dutch universities of applied sciences (in Dutch: hogescholen), and the functioning of training courses that aim to promote creative abilities is highlighted.

Several single-stranded RNA viruses make use of Xrn1-resistant RNAs in their 3’ untranslated regions of their genome RNAs in order to increase their pathogenicity.

Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.

Promotor: Prof.dr. T. Hankemeier, Prof.dr. J.C.T. Eijkel (Twente University)

In the emerging field of small-molecule RNA targeting, there is a growing demand for new high-throughput screening methods.

De wetenschappelijke geschiedenis van Leiden ‘stad van ontdekkingen’ is nu op elke straathoek te vinden. Dankzij 27 nieuwe informatieborden én een app kan iedereen die Leidse ontdekkingen leren kennen.

In this thesis an activity-based probe was discovered that could visualize the activity of PLAATs. With an optimized gel-based ABPP assay in hand, screening of a compound library led to the discovery of alpha-ketoamides as a hit for PLAAT3.

In order to gain a better insight into the basis of the rapid jasmonic acid (JA)-mediated stress response, an integrated approach using a targeted high-resolution mass spectrometry-based (HRMS) platform, was conducted to monitor the metabolism of JA using the model system of cell suspension cultures…

Promotores: Prof.dr. F. van Lunteren, Prof.dr. F.S. Gaastra

Kunst en vrije tijd, Kunst en vrije tijd

Adenosine diphosphate ribosylation (ADP-ribosylation) is a fascinating post-translational modification (PTM) that plays a role in a variety of cellular processes and is associated with several diseases, including cancer and viral infections.

In Leiden zijn veel sporen te vinden van het slavernijverleden, maar die zijn niet bekend bij een groot publiek. De initiatiefnemers van Mapping Slavery in Leiden willen dat veranderen met rondleidingen en markeringspunten. Op herdenkingsdag Keti Koti, 1 juli, kregen vertegenwoordigers van de universiteit…