Het is voor scholen in toenemende mate een forse uitdaging om uitval van docenten op te vangen. Het lerarentekort benadrukt het belang van een ondersteunende werkomgeving en sterke binding tussen docent en school.

Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction.

Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: L.H. Heitman

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman

Stemwijzers—applicaties die kiezers helpen te bepalen welke partij of kandidaat het beste past bij hun politieke voorkeur—spelen een steeds belangrijker rol in verkiezingen. De politicologen Martin Rosema (Universeit Twente) en Tom Louwerse (Universiteit Leiden) onderzoeken of het ontwerp van deze publicaties…

De Universiteit Leiden vindt de aanpassing van het bindend studieadvies geen verstandig plan.

The present thesis focuses on the pharmacological concept of drug-target interaction, which dates back to the beginning of modern pharmacology.

In the emerging field of small-molecule RNA targeting, there is a growing demand for new high-throughput screening methods.

Leiden University offers a unique range of summer courses where you can broaden or deepen your knowledge or share your expertise with fellow students. The choice of academic courses is very diverse, ranging from Law, Big Data, Languages and Linguistics to Maths and Natural Sciences, Biology, Biomedical…

The Study Information Committee works to create a positive and accurate picture of the bachelor and master programs offered by the Institute of Biology Leiden (IBL). The committee consists of IBL staff members and study ambassadors. We reach out to future and current students, high school biology teachers,…

For each living organism health is ensured by correct functioning of its cells. Cells therefore have elaborate methods for regulation of their proteins.

D1.3 describes a set of five case studies relevant in the context of the EuDEco project. Case studies are considered relevant if they are initiatives focusing on the promotion of big data and data reuse or pilots facilitating data reuse in one form or the other. The case studies were expected to allow…

Kinase inhibitors are key therapeutic agents, particularly in oncology, yet their clinical efficacy is often hampered by off-target effects and limited understanding of their cellular target profiles.

During the course of drug discovery translational steps are made.

Endothelial dysfunction and microvascular diseases are key drivers of cardiovascular disease, the world's leading cause of death.

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The cellular metabolism of immune cells constitutes an important part of their proper function and activation. Using T cells as an example, this phenomenon is highlighted by the metabolic reprogramming that occurs in these cells upon activation.

The aim of this thesis is to study cell-cell interactions and the development of an assay to explore and quantify the exchange of membrane compounds.

In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.

Een ambtenaar die wordt vervolgd, kan worden ontslagen ondanks dat hij is vrijgesproken. En soms kan een burger die een vergunning heeft gekregen hier toch geen gebruik van maken zonder onrechtmatig te handelen jegens zijn buurman. Hoe gaat een rechter om met een uitspraak van een collega-rechter?

The studies presented in the work show the potential of the integrative use of biophysical data in defining the structural basis of protein interactions.

Sphingolipids are important membrane compounds with a variety of functions. In mammalian cells, different enzymes are involved in the metabolism of sphingolipids, but interruption of this metabolism process leads to different diseases.

De Universiteit Leiden stopt per direct met het experiment bindend studieadvies in het tweede studiejaar (BSA-2). Studenten moesten in BSA-2 binnen twee jaar 90 studiepunten halen, inclusief hun propedeuse.

In this thesis, the research focuses on the properties of dark matter and dark matter haloes and how they connect with the galaxies we can observe in the Universe.

Zowel de universiteiten als het ministerie van Onderwijs willen dat studenten op tempo studeren. Hoe zorg je daarvoor? De bacheloropleiding Life Science and Technology heeft de laatste jaren een flinke vooruitgang geboekt.

Promotores: F.H.J. Redig, W.T.F. den Hollander

Early time-resolved experiments by Frauenfelder on the ensemble of the kinetic rebinding of CO to myoglobin molecules resulted in a stretched exponential relaxa-tion due to a very large spread of the reaction rates of individual molecules.

This thesis advances our understanding of lipid uptake, a vital first step in lipid metabolism, by developing innovative click chemistry-based tools to study how immune cells internalize lipids.

Promotor: A.P. IJzerman Co-promotor: L.H. Heitman

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

The ideas underlying this thesis are that lipidomics may improve the diagnosis of liver metabolic diseases, and can provide further insights into the underlying pathophysiology of these diseases.

This Thesis focuses on the design and synthesis of ADP-ribosylated compounds that can be applied in biological studies.

This thesis describes a study from both a theoreticaL and an experimental point of view.

Trillende koolstofmonoxide moleculen die zich binden aan het oppervlakte van een zoutkristal, stoppen binnen enkele milliseconden met bewegen. Wetenschappers hebben nu ontdekt dat dit voornamelijk komt door de emissie van elektromagnetische golven. De rol van de chemische binding met het oppervlakte…

The main aim of my Ph.D. thesis is to further explore the value of using early developing zebrafish larvae (up to 5 dpf) as a model to study anxiety-like behaviour and their pharmacological modulation with drugs.

In this thesis we have discussed several parameters that affect the electrochemical conversion of enviromentaly harmful molecules such as nitrates and carbon dioxide to more valuable and less deleterious compounds, in order to cast light onto the mechanism of the reaction to achieve an efficient and…

The endocannabinoid receptors CB1R and CB2R are involved in a plethora of processes, and consequently are involved in many pathological conditions. Their wide distribution makes the CBRs both an interesting therapeutic target and hard to study.

Of all the mass in our Universe, 80% is thought to consist of a hypothetical and invisible substance called dark matter (DM).

This thesis explores how electron paramagnetic resonance (EPR) spectroscopy can be used to investigate key biochemical processes.

Academici hebben op het gebied van inlichtingen geworsteld met de vraag onder welke voorwaarden internationale samenwerking op het gebied van inlichtingen plaatsvindt. De meeste richten zich op transactionele motieven en gegarandeerde opbrengsten, de zogenaamde ‘Quid pro Quo’. Tegelijkertijd wordt vertrouwen…

In this thesis I describe the results of Pulsed Interleaved Excitation and Fluorescence (Cross) Correlation Spectroscopy (PIE-F(C)CS) combined with single-pair Förster Resonance Energy Transfer (spFRET) used to study dynamics in single nucleosomes, which depends on subtle differences in the length of…

This thesis seeks to investigate how cancer-associated mutations affect the pharmacological properties of selected GPCRs—primarily A2AAR and 5-HT2CR—through a combination of ligand binding assays, signaling readouts, kinetic profiling, and cellular functional assays.

Whilst government’s ability to design ‘context-specific’ regional innovation policy is generally assumed to depend on the region’s decision-making power, the aim of this study is to investigate how regional government matters. In order to open up the black box of policy design, the study develops a…

Promotor: Prof.dr. H.V.J. Linnartz

A difficulty of studies on chemical kinetics are the reaction time scales and detection of their intermediates.

The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…

This thesis describes the synthesis and biological evaluation of TLR2/6, TLR4, TLR7/8 and TLR9 ligands, of which the activity can be conditionally controlled.

Promotor: B.van de Water, Co-promotor: L.S.Price

Promotor: Prof.dr. G.P. van Wezel

The cannabinoid receptor type 2 (CB2R) is associated with several inflammatory diseases with an unmet medical need (e.g. Alzheimers, multiple sclerosis, reumatoid arthritis). Development of new chemical biology strategies to study this protein is essential to aid future development of drugs for these…