Bas Rietjens en zijn collega's onderzochten de oorlog tussen Rusland en Oekraïne en onderzochten deze veelvoud aan facetten en hun onderlinge verbanden.

In this article, Jasmijn Boeken, explores in which ways the defining characteristics of the different zones can be found in the digital sphere.

O-Nitrobenzyl groepen worden veel gebruikt als moleculaire beschermgroepen die je met licht kunt verwijderen.

This thesis investigates how non-genetic factors, such as inflammation and concomitant medication, impact hepatic drug metabolism and subsequent drug metabolizing phenotype predictions.

Promotores: C.A.J. Knibbe; J.N. van den Anker, Co-promotores: H.P.A. van Dongen; B. van Ramshorst

Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction.

How are new drugs developed? This question is central to the Minor Modern Drug Discovery (MDD), which covers the entire trajectory from disease to drug molecule and vice versa. The various research groups involved offer a complementary and interdisciplinary perspective by connecting the diverse subjects…

Het primaire doel van de leerstoel is het uitvoeren en bevorderen van wetenschappelijk onderzoek naar de rol van het militaire instrument in hedendaagse conflicten en het verhogen van de kennis daarover in de Nederlandse maatschappij.

In previous studies at our laboratory it was demonstrated that drug exposure of HepG2 cells can lead to an altered TNFα-induced NF-κB oscillatory phenotype, concurrent with a synergistically increased sensitivity for TNFα-induced apoptosis.

Promotor: M. Danhof Co-promotor: O.E. Della Pasqua

In het onderzoeksprogramma Drug Discovery & Safety zijn we geïnteresseerd in de werkzaamheid en veiligheid van nieuwe medicijnen en nieuwe manieren om deze aspecten te bepalen. Daarvoor combineren we geavanceerde imaging en high-throughput screening technieken met computationele aanpakken zoals chem-…

In de specialisatie War and Peace Studies, onderdeel van MSc Crisis and Security Management, krijg je een grondig inzicht in de geschiedenis, theorieën en de huidige en toekomstige beleidsuitdagingen met betrekking tot oorlog, oorlogsvoering en de multidimensionale bevordering van vrede.

Hospital pharmacies face significant challenges: the demand for sterile drug reconstitutions is increasing, while specialized personnel remain scarce. Automation offers a potential solution, but its practical implementation in hospitals is still unclear.

De onderzoeksgroep War, Peace and Justice onderzoekt de samenhang tussen oorlog, vrede en gerechtigheid. Met een multidisciplinaire aanpak brengen onderzoekers en praktijkdeskundigen nieuwe inzichten in conflict, duurzame vrede en mensenrechten, met bijzondere aandacht voor gender en veiligheid.

A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.

De onderzoeksgroep Oorlog, Vrede en Rechtvaardigheid (WPJ) richt zich op de complexe vraagstukken van mondiale conflicten, vrede en rechtvaardigheid, waarbij onderwijskwaliteit een kernfunctie is. Theorie en praktijk komen hier samen, wat een dynamische leeromgeving creëert voor zowel stafleden als…

Promotor: B.van de Water, Co-promotor: L.S.Price

Glucocorticoids are potent anti-inflammatory drugs widely used clinically to treat various inflammatory and immune conditions. However, two main clinical problems limit their use. GCs trigger severe side effects and they induce acquired glucocorticoid resistance, especially during chronic systemic treatment…

In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.

Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.

Over several decades, a variety of computational methods for drug discovery have been proposed and applied in practice. With the accumulation of data and the development of machine learning methods, computational drug design methods have gradually shifted to a new paradigm, i.e. deep learning methods…

Promotor: Prof.dr. M. Danhof, Co-Promotor: J. de Jongh

The Minor Computational Approaches to Disease, Signaling and Drug Targets (CADSDT) is focused on fundamental scientific research required for discovery of new drug targets and development of new drugs.

During the course of drug discovery translational steps are made.

Heart failure is a major health care problem with high mortality.

This thesis describes the importance of being able to control the selectivity of potential drug candidates.

Dit artikel van Michaels onderzoekt hoe externe expertise de productie van inlichtingen en crisisbesluitvorming kan ondersteunen met de casus van Duitsland.

Glycosidases are important enzymes in the turnover of polysaccharides and glycoconjugates, and are involved in a range of human pathologies including genetic disorders such as Gaucher and Pompe disease, but also in various cancers.

This thesis focuses on the application of lipid-based nanomedicine in drug delivery, including small molecular antitumor drugs and biomacromolecules including mRNA, and evaluates their biological performance.

Promotor: A. Kros

Een pilletje op een festival, een biertje in de kroeg, of een sigaret bij de koffie. We wéten dat het slecht voor ons is, maar doen het toch. Hoe komt dat?

Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

Promotor: A.P. IJzerman Co-promotor: L.H. Heitman

The aim of this thesis is to expedite and ensure the systematic accuracy of clearance scaling from adults to paediatric patients, with a special focus on drugs undergoing hepatic metabolism.

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: R.G. Boot

Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.

Promotor: A.P.IJzerman, Co-Promotor: L.H. Heitman

Promotor: A.P.IJzerman Co-promotor: A. Bender

Promotor: B. van de Water

Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.

Promotie

Model based approaches, integrating physiological parameters or linking exposure with response, are powerful tools to quantify and evaluate the impact of genetic differences that are reflected as variability of drug exposure and/or clinical response(s). This thesis “Pharmacogenomics in Drug Development: …

The path to rational drug and dose selection

Verken ons wonderbaarlijke universum vanuit de plaatselijke kroeg!

Aan de hand van een reeks case studies in Irak, Moldavië en Servië gedurende het post-Koude Oorlogstijdperk, onderzoekt dit boek asymmetrische conflicten waarbij de strijdende partijen een grote ongelijkheid in machtsposities vertonen.

Promotores: Prof.dr. C.A.J. Knibbe, Prof.dr. M. Danhof, Prof.dr. K. Allegaert (Leuven)

The research described in this thesis has, using the zebrafish as a model system, shed new light on the intricate relationship between TB and DM2, in particular on the role of leptin, SHP-1 and glucocorticoids.