Promotores: Prof.dr. J. Kuiper, Prof.dr. P.H.A. Quax, Co-promotor: I. Bot

This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).

Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.

Promotor: Prof.dr. J. Kuiper

Soil is a home for an unbelievable diversity and abundance of microbial life that is essential for supporting life on our planet.

Gaucher disease is a rare metabolic disorder, in which a mutation of the enzyme glucocerebrosidase (GBA1) causes buildup of its substrate glucosylceramide and the deacylated counterpart glucosylsphingosine in lysosomes.

Promotie

This minor is focused on fundamental scientific research required for discovery of new drug targets and development of new drugs. Students learn how disease and drug-induced alterations in signaling pathways can be used for the discovery of new drug targets and the development of personalized drugs.

Groeiende gezondheidsverschillen, toenemende zorgkosten, de vergrijzing en het tekort aan zorgpersoneel zijn slechts enkele voorbeelden van uitdagingen waar de gezondheidszorg voor staat, zowel in Nederland als daarbuiten. Deze vraagstukken overstijgen de grenzen van de medische sector en raken aan…

Promotor: Prof.dr. H.J.M de Groot, Co-Promotor: A. Alia

Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang

One of the major limitations in culturing complex tissues or organs is the lack of vascularization in the cultured tissue. Development of a functional capillary bed could overcome this problem.

Promotor: J. Kuiper

The majority (80%) of e-waste generated globally are recycled informally in developing countries.

The research provides insight into disease behavior in both rural and semi-urban areas in Serengeti in Tanzania.

The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.

Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…

Cardiovascular disease is the number one cause of death worldwide. The most important risk factor for developing this disease is high cholesterol levels in the blood.

Promotie

Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen

Promotor: Prof.dr. R.M.H. Merks

The emergence of complex diseases resulting from abnormal cell-cell signaling and the spread of infectious diseases caused by pathogens are significant threats to humanity. Unraveling the dynamic mechanisms underlying cell-cell signaling and infectious disease spreading is crucial for effective disease…

Discover the master program population Health Management at Leiden University and contribute to a more integrated health care system. Learn more!

In this thesis, two potential therapeutic targets for diabetic nephropathy were dentified and investigated. First, we show that glomerular clusterin is upregulated in diabetic nephropathy and demonstrated that recombinant clusterin protein can protect the podocytes against oxidative stress in vitro.…

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof.dr. A.H. Meijer

Promotor: Prof.dr. J.N. Kok, Co-promotor: A.J. Knobbe

The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.

Het Leiden Leadership Centre werkt samen met de onderzoeksgroep Population Health Governance (LUMC-Campus Den Haag) op onderwerpen die raken aan governance en leiderschap in de zorg. Deze onderzoeksgroep is onderdeel van het stimuleringsgebied Population Health van de Universiteit Leiden. Onder de eerste…

De hedendaagse gezondheidszorg staat voor vele uitdagingen. De nieuwe interdisciplinaire master PHM leidt je in twee jaar op om een bijdrage te kunnen leveren aan een meer geïntegreerd gezondheidszorgsysteem.

Binnen dit focusgebied staat gezondheidsbevordering en het stimuleren van fysieke, mentale en sociale veerkracht van de burger centraal.

Discover the Summer School Program Population Health Management by LUMC and learn about strategies to deal with current issues and developments in healthcare.

Binnen dit focusgebied staat de sociale context van gezondheid en welzijn centraal en in het bijzonder sociale ongelijkheid.

Inflammatory skin diseases such as psoriasis and atopic dermatitis can severely impact both the physical and social aspect of a patient’s life. Aberrant inflammatory responses are thought to be a major causative factor in these disorders, but an abundance of different factors contribute to the development…

Discover the master program Health, Ageing and Scoiety at Leiden University and contribute to a future proof health care system. Read more.

The ideas underlying this thesis are that lipidomics may improve the diagnosis of liver metabolic diseases, and can provide further insights into the underlying pathophysiology of these diseases.

De masteropleiding Health, Ageing and Society bereid studenten voor op een betekenisvolle rol in het verbeteren van de kwaliteit van leven van ouderen, en de kwaliteit en organisatie van de zorg voor een verouderende samenleving. Onze studenten voelen zich sterk betrokken bij maatschappelijke vraagstukken…

Binnen dit focusgebied staat het mentale welzijn gedurende het levensloopperspectief centraal. We hebben vooraanstaande onderzoeks- en onderwijsprogramma’s op het gebied van mentale klachten, zoals depressie, angst en stress, in verschillende levensfases, van baby’s tot ouderen, en verschillende contexten,…

This study has been carried out in the community of Sukamiskin, a kelurahan (‘village’) in Bandung, the Capital of West Java Province, located in the Sunda Region of Indonesia.

Promotor: Jan van der Greef; Co-promotors: Mei Wang; Eduard van Wijk

The different kinds of cultural perspectives on health and disease of the participants are related to their knowledge, beliefs, values and practices manifested in various forms of lifestyle in Indonesia. The cultural diversity of the population is also related to differences in health behaviour.

Het thema 'Health and well-being in a healthy society' is één van de speerpunten van de Faculteit der Sociale Wetenschappen (FSW). We zetten ons in voor het bevorderen van gezondheid en welzijn voor mensen van alle leeftijden.

In this thesis, we describe the potential of cell mechanical phenotyping for immune cell characterization, diagnosis, drug testing, as well as treatment of disease.

Promotie

Breast cancer (BC) is a clinically and biologically heterogeneous disease.

Plants and soils from natural ecosystems harbor great diversity of soil microorganisms, which could potentially contribute to the sustainability of horticulture. The knowledge about using wild plant species and soil from natural ecosystem to improve the crop health will advance the application of ecological…

Op donderdag 15 december is Elisavet Alexiadou gepromoveerd op haar proefschrift: ‘The Right to Health. A Human Rights Perspective with a Case Study on Greece'. Promotor was hoogleraar gezondheidsrecht Aart Hendriks.