Promotor: Prof.dr. J.N. Kok, Co-promotor: F.J. Verbeek

Onderzoeksgroepen in het Biological & Soft Matter onderzoeksprogramma ontrafelen de mechanismen in biologische processen en ontwikkelen nieuwe zachte materialen die geïnspireerd zijn door de natuur.

Shape and biological function are tightly connected. Physical descriptions are used to connect the shape of a biological system with its function.

In deze master specialisatie ligt de focus op het begrijpen van biologische processen in hun natuurlijke context, zoals cellen en weefsels.

Promotores: H. Schiessel, G.T. Barkema

This thesis investigates how cell shape and collective behavior influence the dynamics and structure of biological tissues, which are crucial for understanding processes like embryonic development, tissue regeneration, and metastasis.

This dissertation contains four works during my PhD. Different biomaterials have been designed based on coiled-coil peptides. These biomaterials have a range of applications, inclusing drug delivery, cell sorting to cell-cell fusion.

It has been a long-standing mystery how complex biological structures emerge from such seemingly uncoordinated building blocks as cells and tissues, in the presence of only minimal environmental guidance.

Sinds deze zomer is Coen Modderman als fellow verbonden aan de Thorbecke-leerstoel van de Universiteit Leiden.

De prijzen voor de allerbeste masterscripties van de faculteit werden uitgereikt tijdens de internationale conferentie Interaction between Legal Systems.

Op woensdag 15 mei 2013 werd de winnaar bekend gemaakt van de Siegenbeek Scriptieprijs 2012, die dit jaar voor de vijfde keer werd uitgereikt. Coen van Beelen, alumnus Nederlandse taal en cultuur, mocht de prijs in ontvangst nemen voor zijn masterscriptie 'Schrijven met de hamer; het Europese nihilisme…

Antibioticaresistente bacteriën rukken op: mogelijk sterven in 2050 jaarlijks 10 miljoen mensen aan infecties door deze bacteriën. Farmacoloog Coen van Hasselt (LACDR) doet onderzoek naar effectieve behandeling met antibiotica. Hij vertelde over de wapenwedloop tussen bacteriën en nieuwe antibiotica…

Resistentie tegen antibiotica is een groot probleem in de gezondheidszorg. In Van Goed naar Beter vertelt LACDR-farmacoloog Coen van Hasselt over zijn onderzoek naar slimmere manieren om die resistentie te bestrijden.

This PhD-thesis presents a study on micron-sized particles, so-called colloids. By controlling the chemical and physical properties of these particles, such as the interparticle interaction and the particles’ shape, colloids can act as building blocks that self-assembly into larger structures.

Begin juni is bekend geworden dat dr. mr. C. (Coen) Maas is toegelaten tot het Visiting Scholar / Visiting Researcher Program van Harvard Law School. Maas zal daar in het academisch jaar 2016/2017 als visiting researcher werken aan zijn onderzoeksproject 'Debating and Judging Corporate Tax Avoidance:…

The major and ultimate aim of metabolomics is to obtain an answer to a specific biological or clinical question.

Promotor: Prof.dr. P.G.L Klinkhamer, Co-promotor: K. Vrieling

The emergence of complex diseases resulting from abnormal cell-cell signaling and the spread of infectious diseases caused by pathogens are significant threats to humanity. Unraveling the dynamic mechanisms underlying cell-cell signaling and infectious disease spreading is crucial for effective disease…

Parkinson's disease is the second most common neurodegenerative disease in the world. One of its symptoms is the loss of dopaminergic neurons in the substantia nigra pars compacta.

In this thesis, we show how MRFM can usefully contribute to the field of condensed-matter.

Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.

Promotor: A. Kros

Promotor: Prof.dr. J.N. Kok

This work has described synthetic strategies towards well-defined structures resembling capsular polysaccharide (CPS) fragments, CPS mimics, teichoic acid (TA) fragments as well as a third-generation ring-closing tandem metathesis (RCM) linker to better exploit the potential of automated synthesis.

Advanced mass spectrometry of glycosphingolipids takes the central stage in this thesis. Investigations focus on characterization of glycosphingolipid metabolism in health and disease with emphasis to the detection and accurate quantitation of known and so far unknown glycosphingolipids and closely…

Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.

Promotor: Prof.dr. T. Hankemeier, Co-promotor: Theo Reijmers

Promotor: J.G.E.M. Fraaije, Co-Promotor: A. Kros

Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…

Promotor: Prof.dr. T. Hankemeier

Marine sponges are important members of reef ecosystems, as they play ecological roles that are essential for the health of the reef.

Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency

The recently introduced nature-originated deep eutectic solvents, so-called natural deep eutectic solvents (NADES) are considered as truly green solvents, which composed of natural ingredients found abundantly in organisms.

Exploring metabolomics-based biomarkers for diagnosis and treatment response monitoring of community-acquired pneumonia

Kleinere computerchips, smallere cameraatjes; ze worden steeds moeilijker om te maken. Maar wat als de bouwstenen zichzelf opbouwen? Natuurkundige Daniela Kraft bedacht een methode om deeltjes aan te sturen in samenklonteren. Publicatie in ACS Nano.

Op een ogenschijnlijk gewone kubus verschijnt onder druk een patroon van hollingen en bollingen. Er is nu een methode ontwikkeld om zulke 3 dimensionale structuren te ontwerpen en maken met eenvoudige bouwstenen. Publicatie in Nature.

In this thesis an activity-based probe was discovered that could visualize the activity of PLAATs. With an optimized gel-based ABPP assay in hand, screening of a compound library led to the discovery of alpha-ketoamides as a hit for PLAAT3.

Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.

Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

De verklaring van natuurkundige Scott Waitukaitis voor de gillende en stuiterende hydrogelballetjes is door verschillende media overgenomen. Zo was Waitukaitis te zien op het RTL 4 journaal van maandag 24 juli.