De ontwikkeling en bouw van de Cold Optics Bench van het MATISSE-instrument dat onder leiding stond van de Nederlandse Onderzoekschool voor Astronomie (NOVA), is afgerond. Deze Nederlandse bijdrage werd op donderdag 10 april 2014 op de Hannover Messe in Duitsland door ir. Felix Bettonvil van de Leidse…

Quantum hardware comes with a different computing paradigm and new ways to tackle applications. Much effort has to be put into understanding how to leverage this technology to give real-world advantages in areas of interest for industries such as combinatorial optimization or machine learning.

The path to rational drug and dose selection

Nanoparticles can be used as delivery systems for both small molecules and macromolecules such as proteins, peptides or oligonucleotides. This thesis focuses on the use of liposomes, nanometric vesicles formed by a lipid bilayer enclosing an aqueous core. Liposomes are highly versatile delivery syst…

Glycoconjugate vaccines are composed of microbial poly- or oligosaccharides covalently linked to a carrier protein.

The explosive radiation and diversification of the advanced snakes (superfamily Colubroidea) was associated with changes in all aspects of the shared venom system. Morphological changes included the partitioning of the mixed ancestral glands into two discrete glands devoted for production of venom ormucous…

Op 15 april promoveert Shaoyu Wang. Het Leiden University Centre for Linguistics feliciteert Shaoyu!

For optimization problems, it is often unclear how to choose the most appropriate optimization algorithm. As such, rigorous benchmarking practices are critical to ensure we can gain as much insight into the strengths and weaknesses of these types of algorithms.

Taxonomy as a science has accumulated data and knowledge for more than 250 years.

Promotor: P.D. Grünwald

Promotores: H.A. Udo de Haes, H.H.T. Prins, Co-promotor: H.H. de Iongh

Promotor: M.K. Richardson, Co-Promotor: F. Witte

Streptomyces are filamentous bacteria that produce more than two-thirds of known antibiotics.

In principe blijft evolutie altijd doorgaan, maar de factoren die evolutie beïnvloeden veranderen door de tijd heen legt dr. Dusseldorp uit.

The research aims to explore the evolutionary adaptability of enzymes and the impact of temperature on protein evolution pathways, using M. tuberculosis β-lactamase BlaC as the object of study. Enzymes inherently embody a delicate balance between activity and stability, and the acquisition of new enzymatic…

Hieronder vind je de antwoorden op een aantal veelgestelde vragen over toelating tot de klinische specialisaties van de Master Psychologie.

An Active Galactic Nucleus (AGN) is a highly luminous region at the center of a galaxy, powered by the accretion into a supermassive black hole and emitting energy from radio waves to gamma rays, often outshining the host galaxy.

Promotor: P.G.L. Klinkhamer, Co-Promotores: K. Vrieling, P.P.J. Mulder

This thesis involves three topics: benchmarking discrete optimization algorithms, empirical analyses of evolutionary computation, and automatic algorithm configuration.

This thesis investigates how quantum, quantum-inspired, and hybrid quantum-classical computation can enhance key points of the automated machine learning (AutoML) pipeline under the constraints of noisy intermediate-scale quantum (NISQ) devices.

In this thesis we investigate cosmology and the large scale structure of the Universe using cosmological simulations.

This thesis focuses on important life history traits and their trade-offs using two hexapod models. Particularly, the trade-off between immune defense and embryonic developmental speed is a central theme of this study.

Chapter 2 describes a post-synthetic methodology to introduce a fluorescent label in highly lipophilic, Pam3Cys based conjugates.

Promotor: A.W. van der Vaart

The focus of this thesis is on the technical methods which help promote the movement towards Trustworthy AI, specifically within the Inspectorate of the Netherlands.

During the course of drug discovery translational steps are made.

In this thesis, we use low-frequency and high-frequency radio observations to address the following questions regarding quasars: is the radio loud/quiet quasar dichotomy real?

In this work, I explore the creation of new methods that optimize simulations of the gravitational N-body problem. Specifically, I take advantage of the recent popularity of Machine Learning methods to find tools that can suit this problem.

It is a common technique in global optimization with expensive black-box functions to learn a surrogate-model of the response function from past evaluations and use it to decide on the location of future evaluations.

Promotor: Prof.dr. P.G.L Klinkhamer, Co-promotor: K. Vrieling

The main research question of this thesis was: Can nitrogen cycling on dairy farms on peat soil in the Dutch Green Heart area be improved by adapting management to the nitrogen supply from soil and by using other grassland species and crops without affecting milk production?

Promotor: Prof.dr. T.H.W. Bäck

There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.

The increasing resistance of pathogenic bacteria to antibiotics necessitates the discovery of new medicines.

Predictive maintenance (PdM) is a maintenance policy that uses the past, current, and prognosticated health condition of an asset to predict when timely maintenance should occur.

In this PhD-thesis several new and existing data science application are described that are particularly focused on applications for tax administrations.

Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.

Planeetvormingsgebieden, meervoudige sterren en de stofrijke schijven die superzware zwarte gaten voeden. En misschien zelfs vulkanen op de Jupitermaan Io. Al die objecten hopen wetenschappers te gaan waarnemen met de nieuwe supertelescoop MATISSE. De Leidse astronoom Walter Jaffe is onderzoeksleider…

Een internationaal team van sterrenkundigen onder Leidse leiding heeft een wervelwind van stof en gruis ontdekt in een baan rond een jonge ster. In het gruis is zich mogelijk een planeet aan het vormen. Het team van wetenschappers deed de ontdekking in de tijd die bouwers en bedenkers van een astronomisch…

Een internationaal team sterrenkundigen onder leiding van Violeta Gámez Rosas (Universiteit Leiden) heeft een superzwaar zwart gat waargenomen dat verscholen is in een ring van stof. Deze ontdekking past bij het idee dat de zogeheten actieve centra van sterrenstelsels veel meer op elkaar lijken dan…

Learning from small data sets in machine learning is a crucial challenge, especially when dealing with data imbalances and anomaly detection. This thesis delves into the challenges and methodologies of learning from small datasets in machine learning, with a particular focus on addressing data imbalances…

In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.

To gain more insight into the evolutionary development of orchid flowers and fruits, the orchid species Erycina pusilla was studied. The evolutionary origin of the median petaloid sepal, the callus on the labellum, and the stelidia was studied.

Our modern society thrives on chemicals, and demand is only growing with novel chemicals being introduced onto the market. However, with increasing demand, so come potentially increasing ecological consequences of these man-made chemicals.

Promotor: P.M. Brakefield

We have examined sequences from the ligand-binding domain of the nicotinic acetyl choline receptor (nAChR) in 148 vertebrate species. We are in interested in this receptor because the α-neurotoxins of many venomous snakes binds to this receptor in its location at the neuromuscular junction in all ve…

eLaw onderzoekt de rol van het recht in de informatiemaatschappij: hoe kan het recht bijdragen aan een goede werking van informatie- en communicatietechnologie, en het gebruik ervan door burgers, bedrijven en overheden?