Ferritin is a spherical metalloprotein, capable of storing and releasing iron in a controllable way. It is composed of a protein shell of about 12 nm and within its cavity, iron is stored in a mineral form.

Promotor: T.H. Oosterkamp

This thesis explores how electron paramagnetic resonance (EPR) spectroscopy can be used to investigate key biochemical processes.

Multicopper oxidase, laccase, can efficiently reduce oxygen to water and are mostly used in the enzymatic biofuel cells.

Promotor: Prof.dr. M. Ubbink

Promotor: Prof.dr. M. Ubbink

The main subject of this thesis is the design and synthesis of paramagnetic molecules for protein studies with NMR and EPR spectroscopy.

There are many interpretations of quantum mechanics, and ultimately experiments are needed to verify or falsify these interpretations.

The aim of the research presented in this thesis was to develop new methods forchallenging systems in liquid-state NMR using paramagnetic effects generated by thetwo-armed probe CLaNP-5.

Promotor: Prof.dr. M. Ubbink

In this thesis, we describe the latest advances in SQUID-detected Magnetic Resonance Force Microscopy (MRFM).

In this thesis, we show how MRFM can usefully contribute to the field of condensed-matter.

Promotor: Prof.dr. E.J.J. Groenen, Co-Promotor: M. Huber

The thesis describes the use of electron paramagnetic resonance (EPR) spectroscopy, in continuous wave and pulse modes, to address the interaction of α-Synuclein (αS) with membranes and the aggregation of αS.

Dit onderzoekscluster maakt deel uit van het onderzoeksprogramma ‘Institutions, Decisions and Collective Behaviour’.

Protein–protein complexes are formed via transient states called encounter complexes that greatly influence the formation of the stereospecific complex.

Promotor: Prof.dr. H.J.M de Groot, Co-Promotor: A. Alia

The primary goal of this research is to deepen our understanding of substrate-enzyme interactions in Glycoside hydrolases. For this purpose, Bacillus circulans xylanase (BcX) has been selected as a well-established model to examine the Michaelis complex and glycosyl-enzyme adduct.

Binnen het Graduate Programme van Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO) is de aanvraag voor de 'Netherlands Magnetic Resonance Research School' gehonoreerd. Deze onderzoeksschool is een van de 18 gehonoreerde aanvragen. Vier Leidse Graduate Schools zijn gehonoreerd.

Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.

A difficulty of studies on chemical kinetics are the reaction time scales and detection of their intermediates.

Advanced UHF MRI techniques provide powerful tools for studying the zebrafish brain, an emerging model in neurological research. In this work, various MRI and localized MRS methods are optimized and employed for UHF strength for studying the zebrafish brain.

De Tweede Kamerverkiezingen die staan gepland voor maart 2017 zullen resulteren in een versnipperd parlement en een lastige kabinetsformatie, aldus de politicoloog Hans Vollaard (Universiteit Leiden) in een bijdrage aan het EUROPP-blog.

Dit artikel onderzoekt de effecten van de invoering van proportionele vertegenwoordiging (PR) op de politieke vertegenwoordiging van vrouwen.

This article examines how immigration from Central and Eastern Europe influences political support for Eurosceptic parties.

This thesis focuses on amyloid proteins, a class of proteins that convert into amyloid fibrils.

This thesis investigates the relations between metabolism and anatomy through the use of Magnetic Resonance Imaging (MRI).

Speciale versterkstoffen kunnen MRI-scanners honderden malen gevoeliger maken. Leidse fysici hebben nu een methode gevonden om hun efficiëntie te toetsen. Gevoeligere MRI-scans kunnen bijvoorbeeld taaislijmziekte of Parkinson begrijpelijker maken. Publicatie op 18 januari in PCCP.

Light-Harvesting Complex II (LHCII) is responsible for light absorption and excitation energy transfer in plants and photosynthetic algae, while in high light it undergoes conformational changes by which it quenches excitations to prevent photodamage.

Promotor: M. Ubbink, Co-promotor: G. Siegal

Promotores: Prof.dr. J. Aarts, Prof.dr. J.M. van Ruitenbeek

Mocht de PVV bij de Tweede Kamerverkiezingen van 15 maart a.s. als grootste partij uit de stembus komen, moet zij dan – zoals de staatkundige conventie dat wil - ook het initiatief krijgen in de kabinetsformatie?

By growing in a soil plants change the biotic and abiotic properties of the soil in which they grow.

The recently introduced nature-originated deep eutectic solvents, so-called natural deep eutectic solvents (NADES) are considered as truly green solvents, which composed of natural ingredients found abundantly in organisms.

The challenge of achieving fast quantification in metabolomics is the presence of severe matrix effects during the MS analysis of complex samples.

Marcellus Ubbink, hoogleraar Eiwitchemie, heeft een ECHO-subsidie van NWO ter waarde van 260 duizend euro in de wacht gesleept. Met het geld gaat hij onderzoek doen naar enzymremmers.

De tussentijdse verkiezingen in de Verenigde Staten worden een motie van goed- of afkeuring over president Donald Trump en zijn politiek van verdeeldheid, zegt Brendan Carroll, universitair docent Bestuurskunde. In dit blog legt hij uit waarom de opkomst wellicht een beslissende factor wordt.

Promotor: S.M. Verduyn Lunel

‘Legitimacy and Justice’ is een onderzoekscluster binnen het programma ‘Institutions, Decisions and Collective Behaviour’. De wetenschappers die hierin actief zijn houden zich bezig met de legitimiteit en rechtvaardigheid van politieke instituties. Zij kijken in het bijzonder naar de relaties tussen…

We investigate how radiation pressure can be used to influence the mechanical motion of a micro-mirror suspended from springs.

Promotor: M.A.G.J. Orrit

In this Ph.D. thesis we study the interaction of low energy electrons with thin materials, namely layered materials (graphene, hexagonal boron nitride, molybdenum disulfide) and organic films. At these low energies the quantum mechanical wavelength of the electron wave function is in the order of a…

Nature uses a special class of histone proteins, histone variants, to modulate the properties of chromatin at defined genomic locations.

Op vrijdag 25 mei is de oratie van Tjerk Oosterkamp over zijn leeropdracht 'Experimentele Natuurkunde'.