In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…

Promotor: E. Bouwman, Co-promotor: S. Bonnet

Promotores: J. Jonkers, K.E. de Visser

Actinobacteria are well known for the production of bioactive natural products, many of which have applications in the fields of human, animal and plant health. Subject of this thesis are the anthracyclines, glycosylated aromatic polyketides with potent anticancer activity.

Promotores: Prof.dr. H Lenstra, Prof.dr. A Facchini (Padova University)

Promotor: Promotor: W.Th.F. den Hollander, Co-promotor: V. Sidoravicius.

Promotor: Prof.dr. R. Verpoorte, Co-Promotor: Dr. Young Hae Choi

In photoactivated chemotherapy (PACT), a biologically active compound is caged by a light-cleavable protecting group.

As leading cause of death worldwide, cancer is responsible for nearly 10 million deaths in 2020 according to World Health Organization (WHO). Cisplatin and its derivatives are commonly used chemotherapy agents for current cancer treatment in the clinics.

This thesis investigates the structural evolution and assembly of galaxies since the first few billions years after the big bang.

Promotor: F.H.J. Redig, Co-Promotor: W.T.F. den Hollander

It has been a long-standing mystery how complex biological structures emerge from such seemingly uncoordinated building blocks as cells and tissues, in the presence of only minimal environmental guidance.

Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar-Jagalska

Voormalig masterstudent Bio-Farmaceutische Wetenschappen Maddalena Centanni is dit jaar de winnaar van de Arenberg-Coimbragroep-Prijs voor Erasmusstudenten. Centanni bracht voor haar Erasmus-uitwisseling zes maanden door in Uppsala, Zweden. Hier onderzocht ze manieren om de dosering van anti-kankermedicijnen…

Cytotoxic T-cells (CTLs) are involved in the clearance of viruses and killing of tumor cells.

Cancer is considered the silent pandemic of the 21st century and the second leading cause of death worldwide.

One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.

Monoacylglycerol lipase (MAGL) is the principal enzyme responsible for hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-AG). MAGL inhibition provides several potential therapeutic opportunities, including anti-nociceptive, anti-inflammatory and anti-cancer activity.

Streptomyces bacteria are a valuable source of natural products, many of which are used in the clinic or in biotechnology.

Promotor: G.P. van Wezel, Co-promotor: D. Claessen

Promotor: G.P. van Wezel

Filamentous Actinobacteria, such as Streptomyces, produce a plethora of chemically diverse bioactive metabolites that have found applications across medicine, agriculture and biotechnology.

The goal of the research presented in this thesis was to explore the chemical space of ruthenium(II) photocages, investigate their ability to host potent chemotherapy drugs, and to red shift the activation wavelength of the most promising PACT candidates to conduct biological studies.

Metal complexes and 2D materials like graphene were combined to produce structures that can function as sensors.

Promotie

In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…

De Leidse promovendus Xuequan Zhou heeft een veelbelovend nieuw molecuul ontworpen dat effectief kankercellen kan bestrijden zonder hierbij ook de gezonde cellen aan te tasten. De truc: het medicijn wordt pas actief als je het bestraalt met licht. Zhou’s nieuwe molecuul is extra efficiënt, aangezien…

Promotores: H.W. Lenstra, B. Erez, Co-promotor: L. Taelman

In this Yearbook you will find some fascinating examples of what was done in 2021, not only by ourselves, but also by our international colleagues.

Promotor: S.M. Verduyn Lunel, Co-Promotor: O.W. van Gaans

In this thesis we study products of linear error correcting codes.

Promotores: H.W. Lenstra, A. Lucchini

Promotor: W.Th.F. den Hollander Co-Promotor: F.M. Spieksma

This thesis applies data mining in commercial settings in the telecommunications industry.

This thesis seeks to combine two different research topics; Multi-Objective Optimization and Complex Network Analysis.

What physics controls the properties of quantum matter, such as how electrons flow inside high-temperature superconductors? This question has captivated the physics community and industry for decades, in part due to the great technological potential such materials have, but also because they have resisted…

The main subject of this thesis is the design and synthesis of paramagnetic molecules for protein studies with NMR and EPR spectroscopy.

I have studied the hot, diffuse gas around and between galaxies. Specifically, I have used the EAGLE numerical simulations of galaxy formation to predict the properties of this gas, and I have used those properties to predict specific observables: soft X-ray absorption and emission lines.

Promotor: Prof.dr. B. van de Water

This PhD thesis concerns the topic of arithmetic geometry. We address three different questions and each of the questions in some way is about counting how big some set is or can be.

The haplolepideous mosses (Dicranidae) comprise about 4000 species distributed over a wide range of habitats, with great gametophytic and sporophytic morphological variation. Their monophyly is well supported by the results of several molecular phylogenetic studies, which shed light on their relationships…

The prevalence of obesity (BMI >40 kg/m2) has increased rapidly over the recent years, not only in adults, but also in children and adolescents.

Promotor: S.M. Verduyn Lunel, Co-promotor: S.C. Hille

Het doel van het RAISE Onderzoek is om te onderzoeken hoe veerkrachtige mensen omgaan met stress. We kijken specifiek naar hoe belangrijke biologische systemen, zoals de HPA-as en het immuunsysteem, samenwerken met de hersenen en de sociale omgeving om veerkrachtig functioneren na moeilijkheden in de…

Promotor: Prof.dr. C.W.J. Beenakker

Improvements of weak gravitational lensing shape measurements are presented and some used for data analysis.

Promotie

Promotie

The aim of this thesis is to present novel techniques for proving cryptographic schemes secure against quantum adversaries. Most results are within the context of an idealized model called the ‘quantum random-oracle model’.

Electrons in a crystal lattice have properties that may differ from those of a free electron in vacuum.