In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…

Promotor: E. Bouwman, Co-promotor: S. Bonnet

Promotores: J. Jonkers, K.E. de Visser

Promotor: P.J.J. Hooykaas, Co-Promotores: P.B.F. Ouwerkerk, M. Wang

Actinobacteria are well known for the production of bioactive natural products, many of which have applications in the fields of human, animal and plant health. Subject of this thesis are the anthracyclines, glycosylated aromatic polyketides with potent anticancer activity.

Promotor: Promotor: W.Th.F. den Hollander, Co-promotor: V. Sidoravicius.

Promotores: Prof.dr. H Lenstra, Prof.dr. A Facchini (Padova University)

Promotor: Prof.dr. R. Verpoorte, Co-Promotor: Dr. Young Hae Choi

'Foundations 1' takes place on 1-3 March. Do you want to learn more about different types of sources and methods for source analysis in the Dominican convent in Huissen? Register now by sending an email to ozsmed@hum.leidenuniv.nl!

In photoactivated chemotherapy (PACT), a biologically active compound is caged by a light-cleavable protecting group.

As leading cause of death worldwide, cancer is responsible for nearly 10 million deaths in 2020 according to World Health Organization (WHO). Cisplatin and its derivatives are commonly used chemotherapy agents for current cancer treatment in the clinics.

This thesis investigates the structural evolution and assembly of galaxies since the first few billions years after the big bang.

Promotor: F.H.J. Redig, Co-Promotor: W.T.F. den Hollander

Mmmonk en het Henri Pirenne Instituut voor Middeleeuwse Studies (UGent) organiseren eind 2024 de tweede editie van Mmmonk School: Lessen voor gevorderde beginners rond het middeleeuwse boek. Mmmonk School biedt een interdisciplinair praktijkgericht programma over middeleeuwse Vlaamse manuscripten. Experts…

Rector magnificus Carel Stolker neemt op 8 februari afscheid. Als er één thema als een rode draad door zijn carrière loopt, dan is het de verbinding tussen universiteit en maatschappij. In deze serie afscheidsgesprekken gaat Stolker nog eenmaal in gesprek met mensen van binnen en buiten de universiteit.…

It has been a long-standing mystery how complex biological structures emerge from such seemingly uncoordinated building blocks as cells and tissues, in the presence of only minimal environmental guidance.

Op donderdagmiddag 15 mei 2025 organiseert Universitaire Bibliotheken Leiden het symposium ‘De Middeleeuwen als inspiratiebron’. Aanleiding voor dit symposium is de publicatie van het rijk geïllustreerde publieksboek 'Schatten op schrift, 50 manuscripten uit middeleeuws Europa'.

Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar-Jagalska

Theoretisch onderzoek geeft ons niet altijd de beste oplossing voor een probleem in de maatschappij. Dit is de boodschap die wordt verkondigd tijdens de eindpresentaties van de Master Honours Class 'Social Innovation in Action'.

The Vallesian, 11.1-9 Ma, was a special time in the Vallès-Penedes basin near Barcelona, where a biodiversity hotspot existed. Europe had a subtropical climate, with rhinos, forest giraffes, lions, hyenas, flying squirrels and primates.

Promotor: Prof.dr. E.F. van Dishoeck, Co-Promotor: M.R. Hogerheijde

This thesis explores the theoretical and observational properties of distant massive galaxies that harbour active black holes in their centres and shine brightly at radio wavelengths.

This thesis is about the study of hydrocarbons via infrared spectroscopy.

Tijdens deze studiedag zullen – onder voorzitterschap van prof. mr. drs. Mariëlle Bruning – de bevindingen uit de beide dissertaties over gesloten jeugdhulp worden gepresenteerd en zal er vanuit verschillende perspectieven worden gereflecteerd op deze bevindingen en aanbevelingen.

Het Institute of Security and Global Affairs (ISGA) nodigt u van harte uit voor haar openingsconferentie ‘Towards new strategies for contemporary security challenges’ van woensdag 9 tot vrijdag 11 november 2016 in Den Haag.

Voormalig masterstudent Bio-Farmaceutische Wetenschappen Maddalena Centanni is dit jaar de winnaar van de Arenberg-Coimbragroep-Prijs voor Erasmusstudenten. Centanni bracht voor haar Erasmus-uitwisseling zes maanden door in Uppsala, Zweden. Hier onderzocht ze manieren om de dosering van anti-kankermedicijnen…

Cytotoxic T-cells (CTLs) are involved in the clearance of viruses and killing of tumor cells.

Promotor: G.P. van Wezel

Cancer is considered the silent pandemic of the 21st century and the second leading cause of death worldwide.

Promotor: G.P. van Wezel, Co-promotor: D. Claessen

Monoacylglycerol lipase (MAGL) is the principal enzyme responsible for hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-AG). MAGL inhibition provides several potential therapeutic opportunities, including anti-nociceptive, anti-inflammatory and anti-cancer activity.

One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.

Streptomyces bacteria are a valuable source of natural products, many of which are used in the clinic or in biotechnology.

The goal of the research presented in this thesis was to explore the chemical space of ruthenium(II) photocages, investigate their ability to host potent chemotherapy drugs, and to red shift the activation wavelength of the most promising PACT candidates to conduct biological studies.

Metal complexes and 2D materials like graphene were combined to produce structures that can function as sensors.

Filamentous Actinobacteria, such as Streptomyces, produce a plethora of chemically diverse bioactive metabolites that have found applications across medicine, agriculture and biotechnology.

Na bijna veertig jaar keert het tweejaarlijkse congres van de Internationale Federatie van Europees Recht (FIDE) terug naar Nederland!

Promotie

Studievoorlichting

Studievoorlichting

Studievoorlichting

In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…

Studievoorlichting

Studievoorlichting

Studievoorlichting

Studievoorlichting

This project uses archaeological, literary and epigraphic evidence to investigate urban development in Roman-period North Africa, compiling this in a GIS-linked database in order to analyse the development of urban settlement spatially over time.