2,339 zoekresultaten voor “mathematical and statistical modelling” in de Publieke website
-
Mass Spectrometry-Based Degradomics Analysis of Toxoid Vaccines
The chemical and structural heterogeneity of toxoid vaccines makes their analysis challenging. However, detailed insights on a molecular level can be obtained by mass spectrometry.
-
Linking the gene regulatory network with the functional physical structure of whole-genome engineered Arabidopsis mutants : an HR-MAS NMR-based
Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.
-
Resolving the building blocks of galaxies in space and time
We investigate the buildup of galaxies from various vantage points. The first two chapters focus on the stellar content of galaxies, especially the distribution of stellar masses at birth and potential variations therein in various galactic environments.
-
The early stress response of jasmonic acid in cell suspension cultures of Catharanthus roseus
In order to gain a better insight into the basis of the rapid jasmonic acid (JA)-mediated stress response, an integrated approach using a targeted high-resolution mass spectrometry-based (HRMS) platform, was conducted to monitor the metabolism of JA using the model system of cell suspension cultures…
-
Like me or else...
Nature, nurture and neural mechanisms of social emotion regulation in childhood
-
Evolutionary diversification and historical biogeography of Orchidaceae in Central America with emphasis on Costa Rica and Panama
In this thesis, I targeted the orchid genus Lepanthes, one of the six genera of angiosperms that surpasses 1,000 species in the Neotropics, as a study model to investigate the evolutionary processes that promoted species diversifications.
-
Substances from Cradle to Grave
Materials balances have been used in the recent past for the analysis of substance oriented environmental problems and the formulation of measures for environmental policy. In this study an integrated tool, based on the materials balance principle, has been developed for the analysis of both environmental…
-
Solving multiplication and division problems
Latent variable modeling of students' solution strategies and performance
-
Systems pharmacology of the endocannabinoid system
In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).
-
How to scale clearance from adults to children for drugs undergoing hepatic metabolism?
The aim of this thesis is to expedite and ensure the systematic accuracy of clearance scaling from adults to paediatric patients, with a special focus on drugs undergoing hepatic metabolism.
-
Enlightening the Primordial Dark Ages
This thesis is dedicated to the exploration of the primordial dark ages: unknown physics during the earliest stages of the Universe’s expansion that have not yet been directly probed by observations. Cosmic inflation is a burst of exponential expansion of space after the “Big Bang”.
-
representation: An experimental study on teacher-student gender congruence and students’ perceived abilities in math
Onderzoek naar representatieve bureaucratie heeft vaak de positieve prestatie-effecten bevestigd van bureaucratieën die de demografische kenmerken van hun cliënten weerspiegelen. Er is echter weinig bekend over de onderliggende mechanismen op individueel niveau die tot deze resultaten leiden.
-
Anthropomorphic Hegemony of Subjectivity: Critical Reflections on Law and the Question of the Animal
Op 16 december 2019 verdedigde Jan-Harm de Villiers zijn proefschrift 'The Anthropomorphic Hegemony of Subjectivity: Critical Reflections on Law and the Question of the Animal'. Het promotieonderzoek is begeleid door promotor prof.dr. P. Cliteur.
-
Corporate venture management in SMEs: evidence from the German IT consulting industry
Promotor: Prof.dr. B.R. Katzy, Prof.dr. H.J. van den Herik, Prof.dr. G.H. Baltes (University of Applied Sciences Konstanz)
-
Stap 4. Vergelijken en beslissen
Hoe maak je nu de definitieve keuze voor een masteropleiding?
-
Does it still hurt?
The last decades it is increasingly recognized that acute as well as chronic postoperative pain is an important problem. Treatment and prevention of postoperative pain is a challenge, especially in special patient populations where there is only limited guidance on how to optimally use opioids.
-
Morphodynamic equilibria in tidal inlet systems: sensitivity to geometrical variations
A tidal basin is an inland sea which is almost entirely enclosed by land and connected to the open sea by a tidal inlet. Through the tidal inlets interaction takes place between the tidal basin and the open sea.
-
Systems diagnosis of chronic diseases, explored by metabolomics and ultra-weak photon emission
Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang
-
Towards a mechanistic understanding of nanoparticle behavior using zebrafish
The work described in this dissertation contributes to a better mechanistic understanding of nanoparticles in vivo. To achieve that goal, we used the zebrafish as a highly predictive pre-screening model of nanoparticles.
-
Evolution and development of orchid flowers and fruits
To gain more insight into the evolutionary development of orchid flowers and fruits, the orchid species Erycina pusilla was studied. The evolutionary origin of the median petaloid sepal, the callus on the labellum, and the stelidia was studied.
-
Drie Leidse wetenschappers ontvangen NWO ENW-KLEIN subsidie voor vernieuwend onderzoek
De herkomst van Surinaamse rijst, een digitale tweeling van de aarde en een groot big-data project aan de Chileense hemel: drie Leidse wetenschappers ontvangen een ENW-KLEIN subsidie voor vernieuwend, fundamenteel onderzoek.
-
Deze onderzoekers lossen met wiskunde medische problemen op
Twee Leidse wetenschappers laten zien hoe ze met wiskunde onze gezondheidszorg kunnen verbeteren. Daniel Gomon ontwikkelde een model om de kwaliteit van de zorg in ziekenhuizen te monitoren. Marta Spreafico werkt aan een app die artsen helpt bij de behandeling van een type kanker. ‘Het is geweldig wanneer…
-
Prof.dr. Willem Heiser koninklijk onderscheiden
Hoogleraar psychologie Willem Heiser (statistische methoden en datatheorie) is op 31 januari 2014 benoemd tot Ridder in de Orde van de Nederlandse Leeuw. Na zijn afscheidsrede ontving hij de koninklijke onderscheiding wegens uitzonderlijke wetenschappelijke, maatschappelijke en bestuurlijk-organisatorische…
-
NWO subsidie voor IOPS
Het 'Interuniversity Graduate School of Psychometrics and Sociometrics' (IOPS) heeft een bedrag van 800.000 euro toegekend gekregen van NWO voor het opleiden van jonge onderzoekers. Met de financiële impuls kan de onderzoeksschool vier beginnende onderzoekers de ruimte bieden om hun eigen ideeën te…
-
EuDEco Report on the legal analysis (D2.2)
D2.2 comprises the in-depth legal analysis of the initial heuristic model, focused on addressing, in more detail, the main legal concerns for data reusers in the European data economy. This detailed analysis of the legal propositions presented in D2.1 is supplemented by an analysis of the technological,…
-
Innovative (electro-driven) sample preparation tools for metabolomics study of muscle aging
This thesis focuses on the development of sample-preparation methods for small amounts of samples and applying the developed methods to muscle tissues to investigate the mechanisms involved in sarcopenia.
-
Assessing the link between television consumption and the attitudes toward people living with HIV/AIDS in Chile
We analyse the link between media consumption and the attitudes toward people living with HIV/AIDS in Chile. We used data from a sample of 1000 people, obtained in the 2011 wave of the World Values Survey (WVS). We use a logistic binary regression model by maximum likelihood. Our results suggest that…
-
Single-molecule microscopy in zebrafish embryos
Single-Molecule Microscopy (SMM) techniques constitute a group of powerful imaging tools that enable researchers to study the dynamic behavior of individual molecules.
-
Lezingen bij Science
Van zwarte gaten tot kunstmatige intelligentie en van medicijnonderzoek tot data science: welkom in de fascinerende wereld van de Faculteit der Wiskunde en Natuurwetenschappen. Geregeld geven onze onderzoekers, studenten en gasten publieke lezingen over hun werk. U bent van harte uitgenodigd.
-
Search for cosmic neutrinos with ANTARES
Promotor: Prof.dr. M. de Jong, Co-Promotor: A.J. Heijboer
-
Exploring the mechanisms of metastatic onset for novel treatment strategies
This thesis represents a comprehensive investigation into the control of cancer stemness and metastatic initiation using a combination of advanced zebrafish xenograft models and in vitro assays.
-
Economie en transities: ongelijkheid, klimaat en globalisering
Analyse van maatschappelijke vraagstukken vanuit een economisch perspectief.
-
Roland van der Veen ontvangt MAA Beckenbach Book Prize
Het boek ‘The Riemann Hypothesis: A Million Dollar Problem’ is door de Mathematical Association of America (MAA) beoordeeld als een van de beste wiskundeboeken. Op 13 januari ontvangen Leids universitair docent Roland van der Veen en co-auteur Jan van de Craats de MAA Beckenbach Book Prize voor dit…
-
Shekhar Kolipaka
Faculteit der Sociale Wetenschappen
-
Gitta Veldt
Faculteit Rechtsgeleerdheid
-
Simon Portegies Zwart
Wiskunde en Natuurwetenschappen
-
Ewine van Dishoeck
Wiskunde en Natuurwetenschappen
-
Lioe-Fee de Geus-Oei
Faculteit Geneeskunde
-
Hans de Iongh
Wiskunde en Natuurwetenschappen
-
Nieuw onderwijsaanbod 2009
Vanaf september 2009 komt de faculteit met een aantal vernieuwingen in het onderwijsaanbod. Nieuwe leerlijnen zoals Informatica & Economie, Statistical Science, Physics of LIfe, Evolutionary Bio Sciences, Molecular Bio Sciences, colleges van Econophysics verrijken het onderwijs van de faculteit.
-
Onderzoek
Steden, Voedsel, Water, Biodiversiteit, Bronnen en Energie: dit zijn de belangrijkste onderzoeksthema’s voor het CML. Ons doel is altijd om wereldwijd voorop te lopen in ons vakgebied. En echte impact te hebben met onze onderzoeksprogramma’s.
-
Towards artificial photosynthesis: resolving supramolecular packing of artificial antennae chromophores through a hybrid approach
Promotor: H.J.M. de Groot
-
The future of women's health: bioengineered 3D ovarian models
Lezing, NGL-lezing
-
Security in Transnational Spaces
This book focuses on transnationalism as a key concept to evaluate how Europe responds to cross-border security challenges.
-
Computational modeling of non-native phonetic learning and spoken word processing
Lezing
-
Pascal Professor 2015
In 2015 the Pascalchair of the Faculty of Science, Universiteit Leiden and in particular of Leiden Institute of Advanced Computer Science, is held by Prof. Dr. Natasa Jonoska, University of South Florida, Tampa, USA.
-
Meerdere KHMW-prijzen voor Leidse Bèta studenten
Maar liefst zeven eerstejaarsstudenten van de Faculteit Wiskunde en Natuurwetenschappen zijn als jonge talenten in de prijzen gevallen. Daarnaast lauwerde de Koninklijke Hollandsche Maatschappij der Wetenschappen ook drie masterstudenten en een Sterrenkundeproject tijdens een bruisende uitreikingsmiddag…
-
Resolving a bioindicator diatom species complex using genomic approaches for freshwater biomonitoring
This thesis pioneers diatom molecular identification and quantification through genome-scale methods, with four key aims: (i) reviewing DNA/RNA sequencing methods in aquatic biomonitoring to highlight their strengths and limitations;
-
Accelerating the Photocatalytic Water Splitting in Catalyst−Dye Complexes
As a virtually inexhaustible source, solar energy plays a major role in future global energy scenarios.
-
Omics data integration with genome-scale modelling of dopaminergic neuronal metabolism
Promotie