Wat is mijn bijdrage aan onze wereld? Dat is de vraag die studenten en onderzoekers van het Leiden University College The Hague (LUC) zichzelf dagelijks stellen. Ze willen in hun onderwijs en onderzoek stappen vooruitzetten op het gebied van de vier global challenges ‘Peace and justice’, ‘Sustainability’,…

The extensive use of electronic communication channels and other devices has opened new possibilities for collecting data on human behavior. This information is sometimes openly accessible, but largely part of administrative registration systems that are not open to the broader public. The data provides…

What is the effect of light at night on plant phenology and physiology, and how does this affect plant interactions with other species?

In Leiden maak je eerst kennis met het vakgebied, daarna ga je je specialiseren.

In deze masterspecialisatie volg je naast de Nederlandstalige kerncursus en scriptieseminar een aantal Engelstalige vakken en keuzeseminars. In het programma is naast de politiekwetenschappelijke inhoud ook aandacht voor onderzoeksvaardigheden.

De maatschappij en de wetenschap veranderen in hoog tempo door grote ontwikkelingen in digitale informatieverwerking. Het LIACS staat hier middenin met vooraanstaand onderzoek in gegevensverwerking en kunstmatige intelligentie. Dat bereikt het instituut door een unieke combinatie van fundamenteel en…

In de toekomst kan een arts dementie wellicht veel eerder herkennen dan nu het geval is. Een computeralgoritme kan dan op basis van hersenscans voorspellen hoe ons geheugen zich gaat ontwikkelen.

Het LUMC staat voor de verbetering van de gezondheidszorg en de gezondheid van mensen. Deze missie brengen de medewerkers van het LUMC dagelijks in de praktijk met toonaangevend onderzoek, vernieuwend onderwijs en optimale, innovatieve zorg.

Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.

Het boek biedt verschillende theoretische perspectieven om het proces van publieke sector hervormingen te onderzoeken. Daarnaast geeft het een overzicht van de belangrijkste trends in publieke sector hervormingen in Europa en de Verenigde Staten.

Promotor: C.J. ten Cate, Co-promotor: H.W. Slabbekoorn

LIACS is a partner in RISE_SMA, an interdisciplinary, international network combining excellent scholars and practitioners to enable vigorous knowledge sharing and to develop solutions for contemporary challenges for Social Media Analytics (SMA).

Promotor: Prof.dr. G.R. de Snoo, Co-promotor: R. Heijungs

De programmagroep Onderwijswetenschappen verzorgt onderwijs op het gebied van onderwijs, het leren en de ontwikkeling van leerlingen in de schoolcontext. Studenten worden aangemoedigd uitkomsten van wetenschappelijk onderzoek te gebruiken om hun mening over het onderwijsbeleid en de onderwijspraktijk…

The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.

Promotor: P.J.J. Hooykaas, Co-Promotor: E.J. van der Zaal

Cardiovascular syndromes are the major cause of death in Western societies.

How the global distribution of vegetation stands dominated by arbuscular and ectomycorrhizal plants relate to principle aspects of belowground carbon accumulation processes?

Promotor: B. van de Water

This thesis describes the synthesis and biological evaluation of TLR2/6, TLR4, TLR7/8 and TLR9 ligands, of which the activity can be conditionally controlled.

The aim is to discover where differently shaped metal nanoparticles distributes in Danio rerio, linking the distribution with genomic responses and so come up with a Mode of Action.

Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek

In this work, we attempt to answer the question:

Humans and songbirds learn their vocalizations early in life by exposure to the vocalizations of adult conspecifics. Often, better learning outcomes are achieved with live, social, tutors than with audio-only exposure to vocalizations.

Herkennen huisartsen kinderen die (een verhoogd risico voor) angststoornissen hebben en is er een patroon dat kan helpen om kinderen met en zonder angststoornissen te onderscheiden in de huisartsenpraktijk?

Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken

The book ‘Bestrijdingsmiddelen en Milieu' gives a transparent overview of facts and figures concerning pesticide use in the Netherlands and the impact of pesticides on the environment.

The objective of this study was to investigate the expression and function of GRHL2 in different breast cancer subtypes.

The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.

In this Yearbook you will find some fascinating examples of what was done in 2021, not only by ourselves, but also by our international colleagues.

Promotor: Prof.dr. B. van de Water

In this thesis we will explore the use of fuzzy systems theory for applications in bioinformatics.

Promotores: C. J. ten Cate; M. A. Ainslie. Co-promotor: W. Slabbekoorn

Humans perceive the real world through their sensory organs: vision, taste, hearing, smell, and touch. In terms of information, we consider these different modesalso referred to as different channels of information or modals.

The way organisms develop from the initial single-cellular state to a complex final assembly like the human body, and how the final body is maintained throughout life, is one of the greatest mysteries and it’s understanding one of the biggest scientific challenges.

The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.

Source: Structure , Volume 22, Issue 8, pp. 1120-1139 (2014)

Filamentous Actinobacteria, such as Streptomyces, produce a plethora of chemically diverse bioactive metabolites that have found applications across medicine, agriculture and biotechnology.

Promotores: Prof.dr. J.N. Kok, Prof.dr. C.A. Mandemakers, Co-Promotor: G. Bloothooft

Promotores: Prof.dr. M. Danhof, Prof.dr. D.R. Stanski

Lysosomal glycosidases are acid hydrolases that fragment glycoconjugates in lysosomes.

Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.

Bet v1, the major allergen in birch pollen, is one of the main causes of allergies such as asthma and rhino-conjunctivitis. It is the main cause of birch pollen allergy in humans.

Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.

Op 1 april 2020 verdedigde Marc Broekema zijn proefschrift 'Cognitive Bias in the Judgment of Business Valuations and Valuators'. Het promotieonderzoek is begeleid door promotor prof. dr. J.I. van der Rest.

LIBC PUBLIEKSDAG 'HUMAN POTENTIAL; OPTIMALISEER JEZELF, TRAIN JE HERSENEN' (in Dutch)

Promotor: J.N. Kok, P.E. Slagboom Co-promotor: J.F.J. Laros

Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez

Promotores: J.A.van Veen, P.L.G.Klinkhamer. Co-promotor: E.E.Kuramae

The marine shipping industry is one of the strongest emitters of nitrogen oxides (NOx), a pollutant detrimental to ecology and human health. Over the last 20 years, the pollution produced by power plants, the industry sector, and cars has been decreasing.