In this thesis integral points on affine del Pezzo surfaces are studied.

This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).

In times of hardships or crisis, local people know how to deal with it using their resourcefulness. Although efforts are sometimes made by the government to help them, they are fully aware that community support is at least equally important.

Promotor: T.H. Oosterkamp

Promotor: Prof.dr. M. Danhof

Phospholipase A/acyltransferase 3 (PLAAT3) and PLAAT4 are enzymes involved in the synthesis of bioactive lipids. Despite sequential and structural similarities, the two enzymes differ in activity and specificity.

Promotor: R.D. Gill, F. Taroni

Op 16 december 2021 verdedigde Lisanne van Houten het proefschrift 'Flexing the Slot Regime'. Het promotieonderzoek is begeleid door prof.dr. P. Mendes de Leon en prof. L. Pierallini (Luiss University Of Rome).

Cathodic corrosion is a relatively unknown phenomenon that can severely etch metallic electrodes at cathodic (negative) potentials.

Childhood obesity is an increasing health issue. In the first part of this thesis comorbidities in children with obesity were studied, concerning the diagnostic process and dosing regimens.

Promotores: Prof.dr. G.W. Canters, Prof.dr. T.J. Aartsma

Promotor: A. Doelman, Co-promotor: J.D.M. Rademacher

Advanced sensing techniques require graphene with high quality and well-controlled surface chemistry.

Promotor: Prof.dr. P.G.L. Klinkhamer, Co-Promotor: T.J. de Jong

The transition to electric vehicles (EVs) reduces vehicle emissions to combat climate change. EVs raise concerns regarding the production of lithium-ion batteries and related emissions; while batteries can also provide energy storage services for the electricity system.

The main research question of this thesis was: Can nitrogen cycling on dairy farms on peat soil in the Dutch Green Heart area be improved by adapting management to the nitrogen supply from soil and by using other grassland species and crops without affecting milk production?

In most applications, electrocatalysts exhibit a large surface area to volume ratio, for example using nanoparticles.

Promotores: Prof.dr. J. Kuiper, Prof.dr. P.H.A. Quax, Co-promotor: I. Bot

The growing demand of energy indicates that global energy resources in the form of fossil fuels will not be sufficient in the future. In order to solve potential future energy problems development of a sustainable hydrogen economy is highly desirable.

The research aims to explore the evolutionary adaptability of enzymes and the impact of temperature on protein evolution pathways, using M. tuberculosis β-lactamase BlaC as the object of study. Enzymes inherently embody a delicate balance between activity and stability, and the acquisition of new enzymatic…

Promotores: J.A.van Veen, P.L.G.Klinkhamer. Co-promotor: E.E.Kuramae

We find ourselves in an era of transition, not just towards a more computing- and data-driven society but also away from unsustainable fossil fuels as an energy source.

Climate change is one of the largest challenges faced by humanity. To combat this research into alternatives to fossil fuels is ongoing. Dihydrogen is considered a good alternative fuel, since its burning only forms water.

Onder de gezamenlijke titel ‘Scarcity and the State’ verschenen onlangs twee Engelstalige boeken over de verdeling van schaarse publieke rechten (Intersentia 2016). Paul Adriaanse (UL), Frank van Ommeren (VU), Willemien den Ouden (UL) en Johan Wolswinkel (Tilburg University) voerden de redactie. Aan…

De Universiteit Leiden houdt haar drinkwaterverbruik zo klein mogelijk.

In recent decades, climate change has led to more frequent and severe drought events, causing serious consequences such as increased forest mortality and significant crop yield losses. Understanding how drought affects plants, especially economically important herbaceous species, is crucial for predicting…

Promotor: Ronald Cramer, Co-promotor: Serge Fehr

Decarbonizing the building stock is critical for realizing the climate-neutral target for the Netherlands.

It has now been well established that shocks and turbulent motions in the intra-cluster medium (ICM) generated through cluster mergers can produce large-scale synchrotron emission.

Chapter 2 describes a post-synthetic methodology to introduce a fluorescent label in highly lipophilic, Pam3Cys based conjugates.

This study attempts to understand how indigenous community institutions pose an important role in sustainable community-based development, including the integration between local culture and development.

The focus throughout this thesis will be on gathering fundamental studies of the detailed structure and composition of the electrode/electrolyte interface effect on the rate and mechanism of key electrocatalytic reactions.

Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar-Jagalska

The aim of this project was to estimate emissions from lead products-in-use for the past, the present and the future and assess the development of toxicological risks associated with these products.

The experiments described in this thesis employ local lentiviral knockdowns in brain areas of female zebra finches followed by behavioural assays consisting of preference and Go/Nogo tasks.

Promotor: Prof.dr. E. Bouwman, Co-Promotor: S. Bonnet

Promotor: Prof.dr. H. J. A. Röttgering, Co-Promotor: M. Haverkorn

Voor de omzetting van zonlicht naar brandstof

De Universiteit Leiden staat midden in de maatschappij, en wil bijdragen aan een duurzame samenleving. De universiteit kleurt de komende jaren daarom groener.

De duurzame productie van waterstof kan mogelijk efficiënter door slim gekozen zout aan het proces toe te voegen. Onderzoekers van het Leids Instituut voor Chemisch onderzoek hebben in samenwerking met natuurkundigen van de Universiteit Twente ontdekt dat het type zout dat aanwezig is bij de productie…

Promotie

Wat doet de Universiteit Leiden om haar gebouwen en campussen toekomstbestendig en onafhankelijk van fossiele energie te maken?

De Universiteit Leiden is zich bewust van haar rol in de samenleving en wil bijdragen aan een groene, gezonde en inclusieve campus met een positieve impact op het gebied van klimaat en circulariteit.

Een bankier die geld verdienen op de tweede plaats zet én winst maakt. Een boer die stopte met ploegen en insecticiden, maar toch goed oogst. Een nieuw white paper van Leiden-Delft-Erasmus en Naturalis laat zien hoe de ontmoeting van disciplines oplossingen biedt voor klimaatverandering en biodivers…

Het onderzoek binnen de Faculteit der Rechtsgeleerdheid beperkt zich niet tot een enkel speerpunt, maar richt zich op de volle breedte van het recht. Door actuele onderwerpen (zoals kinderrechten, politiek, sport, rampen of criminaliteit) te behandelen en te koppelen aan de wetenschappelijke theorie,…

Promotor: E.F. Smets Co-promotor: J. Geml

How the global distribution of vegetation stands dominated by arbuscular and ectomycorrhizal plants relate to principle aspects of belowground carbon accumulation processes?

Het Leiden University Green Office heeft goed nieuws: je kunt nu de meest milieuvriendelijke zoekmachine - Ecosia - standaard maken op een openbare LU-computer!

This report investigates the different approaches in the authorization process of GMOs for commercial use in the European Union and the United States of America. Three main aspects are considered and analyzed as potential causes of differences in the authorization process of GMOs for commercial use.…