451 zoekresultaten voor “diagnostics and treatment” in de Publieke website
-
Ruthenium-peptide conjugates for targeted phototherapy
As leading cause of death worldwide, cancer is responsible for nearly 10 million deaths in 2020 according to World Health Organization (WHO). Cisplatin and its derivatives are commonly used chemotherapy agents for current cancer treatment in the clinics.
-
Modulation of plant chemistry by rhizosphere bacteria
Plant-microbe interaction resulted in different physio/chemical responses by host plant and interacting rhizobacteria.
-
From midplane to planets : the chemical fingerprint of a disk
This thesis addresses the chemical processes that determine the compositions of giant planet atmospheres.
-
Dosing considerations for preterm neonates: from pharmacometrics to clinical practice
Prematurely born neonates require, amongst others, pharmaceutical therapy. Dosing guidelines for these therapies are often based on data from term born neonates or older infants, while these are not necessarily similar to prematurely born neonates.
-
Metabolomic characteristics of Catharanthus roseus plants in time and space
Promotor: R. Verpoorte, Co-promotores: Y.H.Choi, N.R. Mustafa
-
Inhibitors and activity-based probes for β-D-glucuronidases, heparanases and β-L-arabinofuranosidases
Glycosidases (GHs) are enzymes responsible for the degradation of carbohydrates and play many roles in human health and pathophysiology. Often, abnormal levels of glycosidase activity are markedly linked to human pathologies.
-
study of Vernonia guineensis Benth. (Asteraceae): bioactivity, safety, and phytochemical analysis
Promotor: Prof.dr. R. Verpoorte, Co-Promotor: Dr. Young Hae Choi
-
Sensing Transport
Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.
-
Novel detectors and algorithms for electron nano-crystallography
Promotor: Prof.dr. J.P. Abrahams, Prof.dr. M. van Heel
-
arginine methyltransferases as modulators of lipid metabolism and inflammation and the relevance for atherosclerosis
Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…
-
Development of kinase inhibitors and activity-based probes
Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt
-
Bioengineering and biophysics of viral hemorrhagic fever
Viral hemorrhagic fever (VHF) is a group of acute diseases caused by highly infectious viruses including Ebola, Lassa, Dengue viruses. Its high mortality rate poses high risk to public health, however, studies on VHF have been hampered due to the non-availability of proper models and incomplete knowledge…
-
Activity-based protein profiling of glucosidases, fucosidases and glucuronidases
Promotores: H.S. Overkleeft, G.A. van der Marel, Co-promotor: B.I. Florea
-
Tien jaar Life Science and Technology
Op 9 september 2009 viert de opleiding Life Science and Technology (LS&T) haar tienjarig bestaan.
-
Concerns and opportunities related to discontinuation of treatment in rheumatoid arthritis
Promotie
-
Mattijs Numans
Faculteit Geneeskunde
-
Abdourahamane Idrissa Abdoulaye
Afrika-Studiecentrum
-
Antonius Johannes Rabelink
Faculteit Geneeskunde
-
Alies Jansen
Faculteit der Geesteswetenschappen
-
Inge Ligtvoet
Faculteit der Geesteswetenschappen
-
Liwen Meng
Faculteit der Sociale Wetenschappen
-
Peter van der Zwan
Faculteit Rechtsgeleerdheid
-
Peter de Knijff
Faculteit Geneeskunde
-
Susan van den Brink
Wiskunde en Natuurwetenschappen
-
Nadia Garnefski
Faculteit der Sociale Wetenschappen
-
Barbara Krakovská
Faculteit Governance and Global Affairs
-
Bridging the gap, Pelvic floor physical therapy in the treatment of chronic anal fissure
Promotie
-
Symposium en receptie ter ere van afscheid Rikki Holtmaat
Formele gelijkheid vormt sinds lange tijd het hart van EU en internationaal non-discriminatierecht. Daarnaast is materiële gelijkheid door de jaren heen een wettelijke norm geworden, onder meer door middel van de ontwikkeling van de concepten van indirecte discriminatie en doeltreffende aanpassingen…
-
Waste Collection Systems Assessed and Good Practices Identified (COLLECTORS)
What is the environmental impact of different waste collection systems across Europe? How can the collection be improved when considering collection, sorting, and treatment, as well as use options for secondary materials?
-
From data to models: reducing uncertainty in benefit risk assessment: application to chronic iron overload in children
Promotor: Prof.dr. M. Danhof, Co-promotor: O.E. Della Pasqua
-
characterization of bacterial proteins involved in antibiotic resistance and peptidoglycan biosynthesis
This thesis describes the structural and biochemical characterization of the β-lactamase BlaC from Mycobacterium tuberculosis (Mtb), and the Alr and YlmE proteins from Streptomyces coelicolor A3(2).Mtb is the main cause of tuberculosis.
-
Novel pharmacometric techniques to quantify the pharmacodynamics of analgesics
The overarching clinical aim of this thesis was to improve pharmacological pain management by characterizing the pharmacodynamics of analgesics. This promotion has been awarded the predicate cum laude.
-
from nature: using plant-soil feedback principles to improve growth and health of a horticultural crop
Plants and soils from natural ecosystems harbor great diversity of soil microorganisms, which could potentially contribute to the sustainability of horticulture. The knowledge about using wild plant species and soil from natural ecosystem to improve the crop health will advance the application of ecological…
-
the basis of CSF PK: impact of mechanisms of blood-to-brain transport and within brain distribution
Promotor: M. Danhof, Co-promotor: E.C.M. de Lange
-
Systems pharmacology of the endocannabinoid system
In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).
-
Lipids as therapeutic targets for barrier repair in skin diseases
The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.
-
Evolutionary adaptability of β-lactamase: a study of inhibitor susceptibility in various model systems
β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…
-
Gezochte samenwerkingen
Vanuit de universiteit Leiden zijn wij nog opzoek naar personen en organisaties die ons kunnen helpen bij het uitvoeren van het onderzoeksproject
-
Alistair Kefford
Faculteit der Geesteswetenschappen
-
Corey Williams
Faculteit der Geesteswetenschappen
-
Anthony Brown
Wiskunde en Natuurwetenschappen
-
Firearms and violence in Europe–A systematic review
Firearms and violence in Europe–A systematic review by Katharina Krüsselmann, Pauline Aarten, Marieke Liem
-
Vijf vragen over het onderzoeksprogramma Citizenship, Migration and Global Transformations
De onderzoeksteams zijn opgezet, samenwerkingen zijn gestart, projecten afgetrapt, de eerste startsubsidies zijn binnen en de websites zijn in de lucht. Het stimuleringsprogramma Citizenship, Migration and Global Transformations, dat bestaat uit de twee pijlers Social Citizenship and Migration en Global…
-
Open label placebo voor jeuk
Positieve verwachtingen kunnen het gevoel van jeuk beïnvloeden en placebo-effecten oproepen, terwijl negatieve verwachtingen nocebo-effecten bij jeuk kunnen veroorzaken. Er zijn aanwijzingen dat placebo-effecten ook kunnen optreden wanneer mensen weten dat zij een placebo innemen. Er is weinig bekend…
-
Development of life cycle assessment for residue-based bioenergy
Wat zijn de belangrijkste thema's in het uitvoeren van systemen voor bio-energie ?
-
Conferentie ‘Power and Counterpower in Democracy: Multidisciplinary Perspectives'
Nu zowel oude als nieuwe democratieën steeds vaker te maken krijgen met negative ontwikkelingen op democratisch gebied, is er vanuit maatschappelijk oogpunt behoefte om het ontwerp en de effectiviteit van democratische 'checks and balances' te herzien. Het doel van de conferentie op vrijdag 9 juni is…
-
Wetenschappers
Leidse wetenschappers onderzoeken de wereld om ons heen en geven hun kennis door aan toekomstige generaties. Zij geven gezicht aan de universiteit, ieder met zijn of haar individuele expertise en persoonlijke fascinatie voor het eigen vakgebied.
-
Ubar Kampung
The Sundanese people, the largest ethnic group in West Java, have been using traditional medicine for a long time. Known as ubar kampung, Sundanese indigenous knowledge, beliefs and practices of traditional medicine are based on local people’s knowledge and use of Medicinal, Aromatic, and Cosmetic (MAC)…
-
intermediates for polyurethane plastics for rigid foams/building insulation and coatings
What would be the environmental performance of the Carbon4PUR technology at industrial scale in the future?
-
Development of novel anti-cancer strategies utilizing the zebrafish xenograft model
In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…