534 zoekresultaten voor “heart and vascular disease” in de Publieke website
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Tackling chronic respiratory disease in low-resource settings
Promotie
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Mechanistic Early Phase Clinical Pharmacology Studies with Disease
Promotie
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Iron-immune interactions in Alzheimer's disease
Promotie
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Atherosclerotic cardiovascular disease: Interplay between sex, age, and circadian rhythms
Promotie
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Disentangling the relationship between depression, obesity and cardiometabolic disease
Promotie
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Causal Discovery from High-Dimensional Data in the Large-Sample Limit
Developing robust algorithms and theory for establishing cause-effect relationships from observational data that scale up to large data sets
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Algorithms for finite rings
Promotores: H.W. Lenstra, K. Belabas (University of Bordeaux)
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Accountable Artificial Intelligence: Holding Algorithms to Account
Artificial intelligence algorithms govern in subtle, yet fundamental ways, the way we live and are transforming our societies. The promise of efficient, low‐cost or ‘neutral’ solutions harnessing the potential of big data has led public bodies to adopt algorithmic systems in the provision of public…
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Exposed to events that never happen: Genaralized unsafety and prolonged psysiological stress responses
The aims of the project are to: further clarify 'inhibition by safety'; explore and describe all possible sagety factors, with a special focus on the primary human safety source: social connectedness; reviewing prolonged stress responses without stressors.
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diverse roles of integrin α3β1 in cancer: Lessons learned from skin and breast carcinogenesis
In this thesis, we aim to shed light on the diverse and often opposing roles of integrin α3β1 in cancer.
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Core cross-linked polymeric micelles based on polypept(o)ides: from secondary structure formation of polypeptides to functional cross-linking
This thesis aimed to investigate core cross-linked polymeric micelles (CCPMs) and expand their potential for the delivery of hydrophobic drugs and co-factors.
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Replacing the needle and syringe for vaccine administration
Promotores: Prof.dr. G.F.A Kersten, Prof dr. J.A. Bouwstra
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System-level design for efficient execution of CNNs at the edge
A convolutional neural network (CNN) is a biologically inspired algorithm, highly capable at processing images and videos.
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Topological decoding of biomolecular fold complexity
Biological polymers, including proteins and the genome, undergo folding processes crucial for their proper functioning. Even slight changes in the folding structure of these biopolymers can have significant implications, leading to the development of various pathological conditions, such as neurodegenerative…
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Natural and non-natural factors influencing Alzheimer´s Aβ
Promotor: Prof.dr. J.P. Abrahams
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Human Evolution
This multidisciplinary minor provides students with knowledge on how and why humans became the way they are. The minor focuses on the evolution of the species Homo sapiens from other hominin lineages and animal ancestors, and on the various factors shaping this process. Not only is human evolution of…
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The LeiCNS-PK3.0 model development and applications: healthy-to-diseased CNS pharmacokinetic translation
Accurate prediction of the unbound drug concentration-time profile at the CNS target site is crucial for the assessment of the right drug concentration-effect relationship. PBPK models have supported the PK prediction of the CNS target sites and the translation of PK data between species and between…
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Mechanistic insights into microRNA-based gene therapy for Huntington disease
Promotie
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EUniWell Open Lecture Series | Novel approaches to delay ageing and age-related diseases
Lezing, Lezing onderdeel van serie
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Tien jaar Life Science and Technology
Op 9 september 2009 viert de opleiding Life Science and Technology (LS&T) haar tienjarig bestaan.
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Nieuw project om ziekte van Alzheimer te bestuderen
Onderzoekers van de Universiteit Leiden gaan een nieuwe manier ontwikkelen om de biomarkers van de ziekte van Alzheimer te bestuderen. De aanpak focust zich op de moleculaire boodschappers van de cellen. Het project, geleid door Thomas Hankemeier en gecoördineerd door Yuliya Shakalisava (Leiden Academic…
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Urbanization in Indonesia and Its Impact on Non-communicable Diseases
Promotie
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Aortic valve disease: multimodality imaging for risk stratification and evaluation of therapy
Promotie
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Targeting autoimmunity in renal diseases: focus on neutrophil extracellular traps and autoreactive B-cells
Promotie
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Advanced tools and methods for modeling cardiovascular disease using human pluripotent stem cells
Promotie
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Genetic and clinical pharmacology studies in GBA1-associated Parkinson's disease
Promotie
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Based Pituitary Care, implementing Value Based Health Care in a rare disease
Promotie
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Optimising neonatal management of haemolytic disease of the foetus and newborn
Promotie
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closer look: Non-invasive tools for in-depth characterisation of vulvar diseases
Promotie
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Specifiek eiwit in de hoofdrol bij ziekte van Parkinson
Met elektronspins hebben natuurkundigen het bindingsproces onderzocht van het eiwit α-synucleïne, dat wordt geassocieerd met de ziekte van Parkinson. Wat blijkt is dat het eiwit op een verrassend efficiënte manier bindt aan een hersenmembraan. Met deze in Leiden ontwikkelde methode hebben de onderzoekers…
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elderly in clinical trials: how to define preclinical Alzheimer’s Disease for clinical trial participation
Promotie
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into Cardiac Remodeling, Myocardial Function and Risk Stratification in Cardiovascular Disease
Promotie
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Differences and similarities of autoantibody-positive and autoantibody- negative rheumatoid arthritis during the disease course
Promotie
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Fecal microbiota transplantation and dietary interventions in Inflammatory Bowel Disease; efficacy and challenges for the future
Promotie
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Mattijs Numans
Faculteit Geneeskunde
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Abdourahamane Idrissa Abdoulaye
Afrika-Studiecentrum
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Alies Jansen
Faculteit der Geesteswetenschappen
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Inge Ligtvoet
Faculteit der Geesteswetenschappen
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Liwen Meng
Faculteit der Sociale Wetenschappen
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Peter van der Zwan
Faculteit Rechtsgeleerdheid
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Peter de Knijff
Faculteit Geneeskunde
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Susan van den Brink
Wiskunde en Natuurwetenschappen
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Nadia Garnefski
Faculteit der Sociale Wetenschappen
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Barbara Krakovská
Faculteit Governance and Global Affairs
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Netwerken en community
Het Expertisebureau Diversiteit en Inclusie staat in nauw contact met verschillende studenten- en medewerkersnetwerken op het gebied van diversiteit en inclusie.
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PhD candidate - biodiversity & society: the Dutch home as a multispecies space
Sociale Wetenschappen
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Instituut Biologie Leiden
De natuur is een onuitputtelijke inspiratiebron voor de wetenschappers van het Instituut Biologie Leiden (IBL). Vanuit het streven naar fundamenteel begrip van de natuur zoeken zij naar oplossingen op het gebied van gezondheid en behoud van de biodiversiteit. Het thema van het instituut is ‘Harnessing…
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Is thyroid status a common denominator of age-related disease?
Promotie
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against mycobacterial infection: analysis by a combination of light and electron microscopy
Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn Co-promotor: Dr. M.J.M. Schaaf
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Quantitative pharmacological modelling for optimizing treatment of sepsis
Sepsis is a life-threatening condition caused by a dysregulated host response to infection, it is associated with significant morbidity, mortality, and with a high financial burden on global healthcare systems. Bacterial infections are the primary cause of sepsis, but the growing prevalence of antimicrobial…