1,357 zoekresultaten voor “evolution and development” in de Publieke website
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Using insertional mutagenesis to identify breast cancer drivers and therapy resistance genes in mice
In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.
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First-pass and systemic metabolism of cytochrome P450 3A substrates in neonates, infants, and children
Growth and development affect the metabolism of drugs administered to neonates, infants, and children.
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Human skin equivalents for atopic dermatitis: investigating the role of filaggrin in the skin barrier
Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: A. El Ghalbzouri
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Systems pharmacokinetic models to the prediction of local CNS drug concentrations in human
Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.
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Chenguang Gao
Wiskunde en Natuurwetenschappen
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Xiaoyang Zhong
Wiskunde en Natuurwetenschappen
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Joost Visser
Wiskunde en Natuurwetenschappen
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Kernteam
Het kernteam van het PDC is verantwoordelijk voor onderzoek en ontwikkeling van de LMW-methode en voert het beheer van de LMW trajecten binnen de verschillende deelnemende instellingen.
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Tien jaar Life Science and Technology
Op 9 september 2009 viert de opleiding Life Science and Technology (LS&T) haar tienjarig bestaan.
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Europa en de sociaal-economische kracht van astronomie
Het European Regional Office of Astronomy for Development (E-ROAD) heeft zijn eerste conferentiesessie gehouden tijdens de virtuele EAS Annual Meeting 2020, de grootste astronomieconferentie in Europa. E-ROAD is een initiatief van de Internationale Astronomische Unie en de Universiteit Leiden. Het zet…
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Chemical tools to study the cannabinoid receptor type 2
The cannabinoid receptor type 2 (CB2R) is associated with several inflammatory diseases with an unmet medical need (e.g. Alzheimers, multiple sclerosis, reumatoid arthritis). Development of new chemical biology strategies to study this protein is essential to aid future development of drugs for these…
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Targeting of antigen-presenting cells with mannosylated conjugates
This thesis describes the development of a variety of mannosylated conjugates. Antigen presenting cells bear mannoside recognizing receptors that actively transport antigen into the cell. This thesis exploits this feature for the development of improved vaccines.
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On the origin and evolution of the autoreactive B cell response in rheumatoid arthritis
Promotie
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SCS Courses
The coursework within the Science Communication and Society (SCS) specialisation prepares students for internships and a career in communication about science and health.
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Photo-activation of ruthenium-decorated upconverting nanoparticles
Metal-based prodrugs based on ruthenium(II) polypyridyl complexes have proven to be very suitable for application in both photodynamic therapy (PDT) and photo-activated chemotherapy (PACT).
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Using mouse models to uncover genes driving tumorigenesis and therapy resistance in human breast cancer
To improve cancer treatments, personalized medicine approaches have aimed to identify exactly which mutations are driving tumor development in a given patient and specifically target these mutations using precision therapies.
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Targeting Human Proteasomes: Substrates, Inhibitors and Prodrugs
Large parts of the research described in this Thesis aims at the development of oligopeptide-masked toxins and their in situ immunoproteasome-mediated activation.
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Kasehatan in Sukamiskin: Utilisation of the Plural Health Information and Communication System in the Sunda Region of West Java, Indonesia
This study has been carried out in the community of Sukamiskin, a kelurahan (‘village’) in Bandung, the Capital of West Java Province, located in the Sunda Region of Indonesia.
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Mattijs Numans
Faculteit Geneeskunde
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Abdourahamane Idrissa Abdoulaye
Afrika-Studiecentrum
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Antonius Johannes Rabelink
Faculteit Geneeskunde
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Alies Jansen
Faculteit der Geesteswetenschappen
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Inge Ligtvoet
Faculteit der Geesteswetenschappen
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Liwen Meng
Faculteit der Sociale Wetenschappen
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Peter van der Zwan
Faculteit Rechtsgeleerdheid
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Peter de Knijff
Faculteit Geneeskunde
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Susan van den Brink
Wiskunde en Natuurwetenschappen
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Nadia Garnefski
Faculteit der Sociale Wetenschappen
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Barbara Krakovská
Faculteit Governance and Global Affairs
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Preclinical therapy development in FSHD
Promotie
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Toelatingseisen
De masteropleiding Education and Child Studies is een academische opleiding en biedt op onderzoek gebaseerde kennis over leren en de ontwikkeling van kinderen.
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Toelatingseisen
De masteropleiding Education and Child Studies is een academische opleiding en biedt op onderzoek gebaseerde kennis over leren en de ontwikkeling van kinderen.
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Toelatingseisen
De masteropleiding Education and Child Studies is een academische opleiding en biedt op onderzoek gebaseerde kennis over leren en de ontwikkeling van kinderen.
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Toelatingseisen
De masteropleiding Education and Child Studies is een academische opleiding en biedt op onderzoek gebaseerde kennis over leren en de ontwikkeling van kinderen.
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Toelatingseisen
De masteropleiding Education and Child Studies is een academische opleiding en biedt op onderzoek gebaseerde kennis over leren en de ontwikkeling van kinderen.
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Unfolding the regulation of stress response pathways upon liver injury
Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.
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High-throughput profiling of small molecules using mass spectrometry
Promotor: Prof.dr. T. Hankemeier
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Chemical tools to monitor and control proteasome activities
Promotores: H.S. Overkleeft; G.A. van der Marel Co-Promotor: B.I. Florea
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Mitochondria in chemical-induced toxicity
Chemical-induced organ toxicity is a major concern in the development and use of chemicals, including drugs, pesticides, industrial chemicals and cosmetics. In the last decades, the onset and progression of chemical-induced organ toxicity has been linked amongst others to perturbation of mitochondri…
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Exploring chemical space in covalent and competitive glycosidase inhibitor design
Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency
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Chemical genetic approaches for target validation
Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.
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Functional characterization and unraveling the Gene Regulatory Networks (GRNs) of HD-Zip transcription factor HB40 (and HB22) in Arabidopsis thaliana
In this Ph.D. thesis, we characterized two novel upstream regulators of JUB1, HB40, and HB22, in Arabidopsis thaliana. In Chapter 2, we described functions of HB40 in modulating growth and development via the regulation of JUB1 and GA inactivation genes GA2OXs.
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Contact
Heb je nog vragen over de masterspecialisatie Digital Media in Human Development? Neem dan gerust contact met ons op!
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Stress-induced modulation of the innate immune system in cardiovascular disease
Promotor: Prof.dr. J. Kuiper
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Contact
Heb je nog vragen over de masterspecialisatie Applied Neuroscience in Human Development? Neem dan gerust contact met ons op!
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Education and Child Studies (MSc)
In de masteropleiding Education and Child Studies kies je een specialisatie in één van de deeldisciplines van de pedagogische wetenschappen. In alle specialisaties staat de wetenschappelijke vorming van studenten voorop.
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Contact
Heb je nog vragen over de masterspecialisatie Parenting and Child Development? Neem dan gerust contact met ons op!
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Ruthenium- and cobalt-based artificial metalloenzymes for photocatalytic water oxidation in artificial photosynthesis
Producing green energy has become the main goal in our society in the search of reducing or eliminating the carbon emission from fossil fuels.
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Tuning in to star-planet interactions at radio wavelengths
Low-mass main-sequence stars like our Sun are continuous sources of outflowing hot magnetised plasma. In the case of the Sun, this is known as the solar wind, whereas for other stars they are called stellar winds.
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Inextricable ties between chemical complexity and dynamics of embedded protostellar regions
Promotor: E. F. van Dishoeck, Co-promotor: C. Walsh