This dissertation explores how we can make anomaly detection—identifying unusual or faulty behavior in complex systems—more trustworthy and effective, with a focus on smart manufacturing.

Single-molecule spectroscopy has become a powerful method for using organic fluorescent molecules in numerous applications.

Structural variants (SVs) are the hidden architecture of the human genome, and are critical for us to understand diseases, evolution, and so on.

In the era of big data, extracting insights from complex datasets is a key challenge. This thesis demonstrates the superiority of graph-based methods over traditional clustering (e.g., k-means, DBSCAN) and outlier detection for analyzing high-dimensional and noisy data.

Promotor: Prof.dr. E. Eliel, Co-Promotor: M.J.A. de Dood

Promotor: E. Bouwman, Co-Promotor: S. Bonnet

Op 8 januari 2020 verdedigde Jelmer Brouwer zijn proefschrift 'Detection, detention, deportation'. Het promotieonderzoek is begeleid door promotoren prof.dr. J.P. van der Leun en prof.dr. M.A.H. van der Woude.

Detecting nanoscopic objects plays an important role in nanoscience in particular, in the rapidly growing field of nanobiology. The forebear to modern super-resolution microscopy for single molecule investigation, is fluorescence microscopy.

Promotor: I. Snellen, Co-Promotor: M. Kenworthy

Cardiovascular diseases (CVDs) are the leading global cause of mortality. Endothelial dysfunction, an early reversible stage of CVD development, is marked by decreased nitric oxide production linked to Ca2+ influx in endothelial cells.

The major and ultimate aim of metabolomics is to obtain an answer to a specific biological or clinical question.

Miles Kellerman, universitair docent aan de Universiteit Leiden, stelt dat overheden financiële criminaliteit beter kunnen opsporen door Licensed Detection Agents in te zetten, een soort bounty hunters die structurele tekortkomingen in bestaande detectiesystemen moeten oplossen.

Transport inspectorates are looking for novel methods to identify dangerous behavior, ultimately to reduce risks associated to the movements of people and goods. We explore a data-driven approach to arrive at smart inspections of vehicles.

Promotor: A.W. van der Vaart

Promotor: Prof.dr. J.N. Kok, Co-promotor: A.J. Knobbe

This thesis focuses on amyloid proteins, a class of proteins that convert into amyloid fibrils.

This thesis focuses on protoplanetary disks: flattened structures of gas and dust around young stars in which planets are expected to form and grow.

Promotores: Prof.dr. D. Bouwmeester, Prof.dr. A. Fiore (TU Eindhoven)

In this work, we attempt to answer the question:

This thesis seeks to combine two different research topics; Multi-Objective Optimization and Complex Network Analysis.

Met grote droefenis delen wij mede dat Piet van de Putte op 7 November 2016 is overleden.

The physical origin of the dozens of stellar-mass binaries, the mergers of which have been detected by the LIGO-Virgo-KAGRA collaboration via gravitational waves, is still unknown.

In this thesis we use state-of-the-art observations and simulations to provide the best constraints to date on the HVS ejection rate and constraints on the stellar content and dynamics at the GC, including the progenitor binary populations and their star formation history.

In this PhD-thesis several new and existing data science application are described that are particularly focused on applications for tax administrations.

Overlevingsanalyse is een onderzoeksgebied dat zich richt op het bestuderen van de tijd tot het optreden van een specifieke uitkomst.

This thesis aims to improve the detection from ultra-weak single emitter by enhancing their emission properties with plasmonic nanostructures. We exploit the wet-chemically synthesized single crystalline gold nanorods (GNRs) as our basic frameworks in the whole studies, simply because of their unique…

Understanding the formation and evolution of planetary systems is one of the most fundamental challenges in astronomy. To directly image and study young exoplanets and the circumstellar disks they form from, dedicated high-contrast imaging instruments are built.

Tracing the evolution of the molecular gas content in galaxies is critical for a complete understanding of galaxy formation and evolution, as it provides the direct fuel for star formation. Studies of high-redshift (z>1) molecular gas reservoirs, most commonly traced by carbon monoxide (CO), have seen…

Promotor: J.N. Kok, Co-Promotor: A.J. Knobbe

As a non-invasive genetic method, eDNA based approaches have become an important component of ecologists' and environmental managers' toolkits for biomonitoring in conservation and an increasingly important source of ecological knowledge.

This thesis investigates Open-world Continual Learning (OWCL), a learning paradigm designed for intelligent systems operating in non-stationary environments with persistent exposure to unknown data.

With the emergence of online social networks (OSNs), the way people create and share information has changed, which becomes faster and broader than traditional social media.

Promotor: H.J.A. Röttgering, Co-promotor: G.K. Miley

In this thesis chemical and physical processes in the ice mantles on interstellar dust grains are studied.

The first direct detection of gravitational waves opened the possibility of mapping the Universe via this new and independent messenger.

Gold nanoparticles show surprisingly strong interactions with light in the visible range, which can be divided into scattering, absorption, and photoluminescence.

The ideas underlying this thesis are that lipidomics may improve the diagnosis of liver metabolic diseases, and can provide further insights into the underlying pathophysiology of these diseases.

Metabolomics is a powerful tool that can provide a comprehensive insight into the complexity of human biology and the pathophysiology of diseases. By analyzing the metabolome, which refers to the complete set of small (endogenous) molecules (with a mass <1500 Da) present within a given biological system,…