Onderzoek naar representatieve bureaucratie heeft vaak de positieve prestatie-effecten bevestigd van bureaucratieën die de demografische kenmerken van hun cliënten weerspiegelen. Er is echter weinig bekend over de onderliggende mechanismen op individueel niveau die tot deze resultaten leiden.

The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.

One of the effects of climate change is the phenomenon of desertification, a process that occurs in semi-arid and arid areas and causes land degradation as well as vegetation loss. Due to the lack of resources, vegetation self-organizes to sustain itself by forming large-scale spatial patterns.

Gibbs measures, as used in Statistical Mechanics, have a definition that is remarkably similar to the definition ofg-measures, used in dynamical systems.

This thesis is devoted to an in-depth examination of the various effects of disorder in the cuprate high-temperature superconductors.

Modeling and analysis of cyber-physical systems are still challenging. One reason is that cyber-physical systems involve many different parts (cyber or physical), of different nature (discrete or continuous), and in constant interaction via sensing and actuating.

The effective treatment of tuberculosis (TB) remains a major challenge to global health.

Plant-microbe interaction resulted in different physio/chemical responses by host plant and interacting rhizobacteria.

It has now been well established that shocks and turbulent motions in the intra-cluster medium (ICM) generated through cluster mergers can produce large-scale synchrotron emission.

This thesis addresses the chemical processes that determine the compositions of giant planet atmospheres.

Promotor: Promotor: W.Th.F. den Hollander, Co-promotor: V. Sidoravicius.

Promotor: Prof.dr. B.R. Katzy, Prof.dr. H.J. van den Herik, Prof.dr. G.H. Baltes (University of Applied Sciences Konstanz)

A tidal basin is an inland sea which is almost entirely enclosed by land and connected to the open sea by a tidal inlet. Through the tidal inlets interaction takes place between the tidal basin and the open sea.

Van ambitie tot actie: autonoom leren structureel verankeren in het Leidse onderwijs

During my PhD research, I studied the photon statistics of light emitted by a microcavity that contains a single quantum dot (QD) on resonance.

Vast, often populated, areas in dryland ecosystems face the dangers of desertification.

High-angular-resolution observations of the circumstellar material have uncovered numerous and very diverse substructures in protoplanetary discs, raising the question of whether they are caused by forming planets or other mechanisms.

Promotor: J.N. Kok, Co-promotor: C.M. Soares, A.J. Knobbe

Promotor: Prof.dr. M. Ubbink

The chemical and structural heterogeneity of toxoid vaccines makes their analysis challenging. However, detailed insights on a molecular level can be obtained by mass spectrometry.

Promotor: A. Kros

Low-mass main-sequence stars like our Sun are continuous sources of outflowing hot magnetised plasma. In the case of the Sun, this is known as the solar wind, whereas for other stars they are called stellar winds.

In de onderzoekslijn Geneesmiddelenonderzoek werken we voornamelijk met knaagdieren. Knaagdieren, zoals muizen, worden veel gebruikt als proefdier. Deze kleine zoogdieren zijn makkelijk te houden en planten zich snel voort.

This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.

The last decades it is increasingly recognized that acute as well as chronic postoperative pain is an important problem. Treatment and prevention of postoperative pain is a challenge, especially in special patient populations where there is only limited guidance on how to optimally use opioids.

Promotor: R. Cramer

Promotor: Prof.dr. M. de Jong

Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.

Promotor: E. F. van Dishoeck, Co-promotor: C. Walsh

Time-series forecasting through modelling sequences of temporally dependent observations has many industrial and scientific applications. While machine learning models have been widely used to create time-series forecasting models, creating efficient and performant time-series forecasting models is…

Hoe helpen demonstratie-experimenten in de klas leerlingen om te leren chemisch redeneren?

The studies presented in the work show the potential of the integrative use of biophysical data in defining the structural basis of protein interactions.

My work focuses on a class of astronomical objects called protoplanetary disks.

In the early universe, the dynamics of the Higgs field can give rise to many interesting phenomena.

The aim of this thesis is to expedite and ensure the systematic accuracy of clearance scaling from adults to paediatric patients, with a special focus on drugs undergoing hepatic metabolism.

Dit proefschrift onderzoekt hoe golven zich gedragen in een imperfecte omgeving. Denk aan een golf op het wateroppervlak na een passerende boot: ook als de boot al lang weg is, blijft de golf nog een tijd zichtbaar. Maar wat gebeurt er als de golf realistische oneffenheden of verstoringen tegenkomt?

Veel belangrijke onderwerpen in de informatica, zoals de juistheid van software, de efficiëntie van algoritmen en de modellering van gecompliceerde systemen, zijn afhankelijk van een goede theoretische onderbouwing. In de Theoriegroep bestuderen we deze fundamentele bouwstenen en ontwikkelen we verificatiemethoden…

Jongeren met psychopathische eigenschappen vertonen relatief vaak crimineel gedrag. Daarom is het belangrijk hen goed te kunnen herkennen. Wendy Zwaanswijk ontwikkelde en testte een nieuw meetmodel om psychopathische jongeren te beschrijven. Promotie op 6 september.

Quantitative biology means exploiting mathematical modelling and computer simulation as a tool to gain additional insights into the meaning of experimental data. Discover in this minor when and how to apply these tools, in a multidisciplinary setting.

De herkomst van Surinaamse rijst, een digitale tweeling van de aarde en een groot big-data project aan de Chileense hemel: drie Leidse wetenschappers ontvangen een ENW-KLEIN subsidie voor vernieuwend, fundamenteel onderzoek.

Twee Leidse wetenschappers laten zien hoe ze met wiskunde onze gezondheidszorg kunnen verbeteren. Daniel Gomon ontwikkelde een model om de kwaliteit van de zorg in ziekenhuizen te monitoren. Marta Spreafico werkt aan een app die artsen helpt bij de behandeling van een type kanker. ‘Het is geweldig wanneer…

Promotor: Prof.dr. E. Bouwman

De masteropleiding Statistics & Data Science is een tweejarige master waarbij een diep doorgronde introductie wordt gelegd aan de algemene filosofie en methodologie van statistische modellen, statistisch modelleren, data analyse en data science, met de voornaamste focus op toepassingen in levens- en…

Bij Data Science & Artificial Intelligence leer je hoe je functies van het brein, zoals denken, geheugen, leren en aandacht in modellen kunt gieten. Deze kennis kun je gebruiken om computers en systemen op vergelijkbare of betere manieren te laten functioneren.

This thesis focuses on the development of sample-preparation methods for small amounts of samples and applying the developed methods to muscle tissues to investigate the mechanisms involved in sarcopenia.

Tijdens deze masterclass krijg je:

Teaching Fellows presenteren hun projecten op het gebied van ICT&O.