Promotor: Prof.dr. J.P. Abrahams, Co-Promotor: N.S. Pannu

Heterogeneous catalysis is one of the fundamental processes of modern life, being common in industrial refinery and hydrogen vehicles, all the way to the living cell. The dissociation of H2 on Cu(111) is an important benchmark system for studying heterogeneous catalysis, with a large and varied amount…

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Producing green energy has become the main goal in our society in the search of reducing or eliminating the carbon emission from fossil fuels.

Promotor: E. Bouwman, Co-Promotor: S. Bonnet

Metals surfaces form a group of effective catalysts for the reaction of small molecules such as hydrogen (H2).

Schistosomiasis is an acute and chronic disease caused by blood dwelling parasitic trematodes of the genus Schistosoma, and it is classified as the second most socioeconomically devastating parasitic disease, second only to malaria.

The main subject of this thesis is the design and synthesis of paramagnetic molecules for protein studies with NMR and EPR spectroscopy.

Promotor: Prof.dr. J.P. Abrahams, Prof.dr. M. van Heel

Promotor: Prof.dr. J.G.E.M. Fraaije, Co-promotor: A. Kros

Sustainable energy from wind and solar is most readily available near the sea.

A key step in the synthesis of oligosaccharides and glycoconjugates is the formation of the glycosidic bond.

One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.

Promotor: A. Kros, Co-promotor: R.R.C.L. Olsthoorn

Monoacylglycerol lipase (MAGL) is the principal enzyme responsible for hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-AG). MAGL inhibition provides several potential therapeutic opportunities, including anti-nociceptive, anti-inflammatory and anti-cancer activity.

Aspergillus niger is an important industrial producer of organic acids and enzymes producing large amounts of spent fungal biomass.

Several single-stranded RNA viruses make use of Xrn1-resistant RNAs in their 3’ untranslated regions of their genome RNAs in order to increase their pathogenicity.

This Thesis focuses on the design and synthesis of ADP-ribosylated compounds that can be applied in biological studies.

The redox-conversion reaction of metal-disulfide and metal-thiolate complexes are important, as they may shed light on electron-transfer reactions that often occur in Nature.

De Faculteit der Wiskunde en Natuurwetenschappen is gevestigd op verschillende locaties in het Bio Science Park Leiden.

Het beste van Leiden en Delft komt samen in de bachelor opleiding Life Science & Technology. Benieuwd naar het programma? Bekijk de video.

The studies presented in the work show the potential of the integrative use of biophysical data in defining the structural basis of protein interactions.

The growing demand of energy indicates that global energy resources in the form of fossil fuels will not be sufficient in the future. In order to solve potential future energy problems development of a sustainable hydrogen economy is highly desirable.

Antibioticaresistentie is een van de grootste bedreigingen wereldwijd voor de volksgezondheid in de komende decennia.

Lipid nanoparticles (LNPs) have enabled the success of mRNA vaccines but remain limited in broader therapeutic use by challenges in delivery efficiency, targeting, and mechanistic understanding.

Gaucher disease is a rare metabolic disorder, in which a mutation of the enzyme glucocerebrosidase (GBA1) causes buildup of its substrate glucosylceramide and the deacylated counterpart glucosylsphingosine in lysosomes.

This thesis investigates catalytic reactions at the atomic scale using scanning tunneling microscopy (STM), with a focus on Fischer–Tropsch synthesis, a key industrial process that converts hydrogen and carbon monoxide into liquid fuels.

This thesis investigates innovative and classical strategies in glycoconjugate vaccine development to address the growing threat of multidrug-resistant bacterial infections.

This thesis focuses on developing new chemical synthesis strategies to produce native ADP‑ribosylated biomolecules with precise structural control.

In the emerging field of small-molecule RNA targeting, there is a growing demand for new high-throughput screening methods.

We willen allemaal een wereld waarin individuen veilig zijn, conflicten vreedzaam worden beslecht en rekening wordt gehouden met toekomstige generaties. Juristen van de Universiteit Leiden onderzoeken in hoeverre het internationaal publiekrecht voorziet in de behoeftes van een geglobaliseerde samenleving.…

Metal-based prodrugs based on ruthenium(II) polypyridyl complexes have proven to be very suitable for application in both photodynamic therapy (PDT) and photo-activated chemotherapy (PACT).

Promotor: Huub J.M. de Groot, Co-promotor: Francesco Buda

Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée

Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.

In this thesis an activity-based probe was discovered that could visualize the activity of PLAATs. With an optimized gel-based ABPP assay in hand, screening of a compound library led to the discovery of alpha-ketoamides as a hit for PLAAT3.

In surface science there is great effort to move from studying simple, flat model surfaces in vacuum to investigating more complex model catalysts in gas environments (in situ). This thesis gives three examples of such studies using microscopy and spectroscopy.

In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.

Promotor: Prof.dr. M. Ubbink

Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.

Promotor: Prof.dr. G.J. Kroes

Promotor: Prof.dr. H.S. Overkleeft

Een uitgave in de serie Handboeken Veiligheid, waaraan ook Erwin Muller, hoogleraar veligheid en recht bij het Instituur voor Strafrecht & Criminologie , een bijdrage heeft geleverd.

Microglia support the central and peripheral nervous system by forming the first line of defense against hazardous events. Microglia are increasingly acknowledged as critical players in neurodegenerative diseases, highlighting them as potential therapeutic targets.

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: R.G. Boot

Artificial photosynthesis has recognised potential to produce green and sustainable fuels from earth-abundant resources such as water, carbon dioxide (CO2), and sunlight.