Endocannabinoids are lipid messengers that modulate various physiological functions by activating the cannabinoid CB1 and CB2 receptors. While the metabolism of endocannabinoids and their action at the CB receptors is fairly well studied, the molecular mechanisms governing their release and transport…

This thesis investigates the evolution and fate of gaseous exoplanets, which are continuously shaped by stellar activity across both short and long timescales.

In our research protein translocation from Agrobacterium into yeast and plant cells is studied to obtain fundamental insights in the translocation process

The focus of this thesis is on the technical methods which help promote the movement towards Trustworthy AI, specifically within the Inspectorate of the Netherlands.

Detecting nanoscopic objects plays an important role in nanoscience in particular, in the rapidly growing field of nanobiology. The forebear to modern super-resolution microscopy for single molecule investigation, is fluorescence microscopy.

This dissertation focused on computational methods based on first principles calculations using the Density Functional Theory (DFT) framework. Emphasis was laid on affordable methods that can provide a tradeoff between computational expense and accuracy.

Open Science en Erkennen & Waarderen komen samen in dit universiteitsbrede programma.

The origin and evolution of galaxies are closely linked to many different physical phenomena.

Autopaghy is an intracellular degradation system which targets cytosolic components to lytic compartments for degradation and recycling of the building blocks of the cell.

In this thesis chemical and physical processes in the ice mantles on interstellar dust grains are studied.

Radio jets are important to the evoultion of galaxies. However, it is still not fully understood how a radio jet can be triggered.

Accurate prediction of the unbound drug concentration-time profile at the CNS target site is crucial for the assessment of the right drug concentration-effect relationship. PBPK models have supported the PK prediction of the CNS target sites and the translation of PK data between species and between…

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: J.D.C. Codee

The European Council and the European Commission have a similar role in agenda setting. Both place issues on the EU agenda. However, these institutions have distinct designs. They have different political attributes (the European Council has considerably more political authority) and information-processing…

Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction.

Self-assembly offers a promising route to create complex structures and materials using simple building blocks. Through, colloidal self-assembly, we can understand the governing principles of the self-assembly process and unlock its potential in diverse applications in materials science, photonics and…

Promotor: Prof.dr. E.J.J. Groenen, Co-Promotor: M. Huber

Promotor: A. Doelman, Co-promotores: P.J.A. van Heijster; A. Zagaris

The thesis is about the study of shell evolution of the Hydrocenidae of the genus Georissa. This thesis started with a general overview on the evolutionary process of animals due to ecological changes.

Promotor: M.T.M. Koper, Co-Promotor: L.B.F. Juurlink

Galaxies in the Universe are distributed along the intricate framework of the Cosmic Web. Groups and clusters of galaxies comprise the densest regions in this network, and therefore, are excellent cosmic laboratories to study different aspects of galaxy evolution in extreme environments.

The research of the Applied Mathematics cluster is concerned with such diverse topics as dynamical systems, representation theory, differential equations and pattern recognition.

The idea of citizens and public professionals collaborating to provide public services has widely spread in several countries around the globe. Co-production is often presented as the go-to solution for challenges like a legitimacy crisis of both the government and the market, and financial concerns.…

This thesis advance our understanding and the application of molecular catalysts relevant to the reduction of oxygen as well as reduction of nitrite.

Cytotoxic T-cells (CTLs) are involved in the clearance of viruses and killing of tumor cells.

Het is voor scholen in toenemende mate een forse uitdaging om uitval van docenten op te vangen. Het lerarentekort benadrukt het belang van een ondersteunende werkomgeving en sterke binding tussen docent en school.

It has been a long-standing mystery how complex biological structures emerge from such seemingly uncoordinated building blocks as cells and tissues, in the presence of only minimal environmental guidance.

There is a need for alternative methods to replace, reduce and refine (3R) animal experimentation. Combining experimental data from high-throughput in vitro studies with in silico modeling is a promising approach to unravel the effect of chemicals on living cells and to gain a better understanding of…

Niets heeft zo’n invloed gehad op het verloop van de wereldgeschiedenis als de grote metamorfose van de menselijke samenleving in de afgelopen tweehonderd jaar.

Promotor: H.J.A. Röttgering, Co-promotor: G.K. Miley

Software development is a complex process. It is important that software products become stable and maintainable assets.

This thesis focuses on two processes involved in fighting infections: metabolism and immune cell motility and navigation.

In this thesis, we developed new ways to use a technique called electroextraction (EE) to extract charged molecules from one liquid into another using an electric field.

This thesis covers various applications of topology in condensed matter physics and quantum information.

Op donderdag 9 november is Reijer Passchier gepromoveerd op zijn proefschrift over ‘informal constitutional change’. Zijn promotor is Professor Wim Voermans.

Promotor: Prof.dr. J.N. Kok, Co-promotor: F.J. Verbeek

N-acylethanolamines (NAEs), including N-arachidonoylethanolamine (anandamide, AEA), N-palmitoylethanolamine (PEA) and N-oleoylethanolamine (OEA), are signaling lipids that play an important role in different physiological process.

Promotor: Prof.dr. A.G.G.M. Tielens, Prof.dr. C. Dominik (UvA)

De programmagroep Onderwijswetenschappen heeft expertise op het gebied van het levenslang lerende individu in het onderwijs, met veel aandacht voor lerende kinderen.

Promotor: E.R. Eliel, Co-Promotor: M.J.A. de Dood

Promotor: Prof.dr. M.T.M. Koper, Co-Promotor: F. Calle-Vallejo

Promotor: Prof.dr. P. Hooykaas, Co-promotor: R. Offringa

Molecular complexes can be used as electrocatalysts for oxygen reduction, water oxidation, and/or hydrogen peroxide production.

This multidisciplinary minor provides students with knowledge on how and why humans became the way they are. The minor focuses on the evolution of the species Homo sapiens from other hominin lineages and animal ancestors, and on the various factors shaping this process. Not only is human evolution of…

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Door beschikbare data slim te gebruiken kan de gezondheid van én de zorg voor mensen substantieel verbeterd worden. Marco Spruit wil de komende jaren taal- en machine learning gebruiken om de grootste zorgvraagstukken in de regio Den Haag te duiden en op te lossen. Hij is 1 december 2020 aangesteld…