1,881 zoekresultaten voor “state cell technology” in de Publieke website
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Alies JansenFaculteit der Geesteswetenschappen
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Gitta VeldtFaculteit der Rechtsgeleerdheid
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Rafaël VosFaculteit der Wiskunde en Natuurwetenschappen
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Exploring big data approaches in the context of early stage clinical
Als gevolg van de grote technologische vooruitgang in de gezondheidszorg worden in toenemende mate gegevens verzameld tijdens de uitvoering van klinische onderzoeken.
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Using insertional mutagenesis to identify breast cancer drivers and therapy resistance genes in mice
In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.
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Role of non-homologous end-joining in T-DNA integration in Arabidopsis thaliana
Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater
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Developing systems for high-throughput screening of infectious diseases using zebrafish
Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof.dr. A.H. Meijer
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CE-MS for metabolomics: advancing performance and detection sensitivity
The major and ultimate aim of metabolomics is to obtain an answer to a specific biological or clinical question.
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Direct and two-step activity-based profiling of proteases and glycosidases
Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel
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Allosteric modulation by sodium ions and amilorides of G protein-coupled receptors
Promotor: A.P. IJzerman
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Transcultural Health Care Utilisation in Serengeti of Tanzania: Towards Applied Ethnoscience in Public Health Management
The research provides insight into disease behavior in both rural and semi-urban areas in Serengeti in Tanzania.
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To explore the drug space smarter: Artificial intelligence in drug design for G protein-coupled receptors
Over several decades, a variety of computational methods for drug discovery have been proposed and applied in practice. With the accumulation of data and the development of machine learning methods, computational drug design methods have gradually shifted to a new paradigm, i.e. deep learning methods…
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Time is of the essence: investigating kinetic interactions between drug, endogenous neuropeptides and receptor
Promotor: A.P. IJzerman Co-promotor: L.H. Heitman
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Allosteric modulation and ligand binding kinetics at the Kv11.1 channel
Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: L.H. Heitman
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Structural characterization of bacterial proteins involved in antibiotic resistance and peptidoglycan biosynthesis
This thesis describes the structural and biochemical characterization of the β-lactamase BlaC from Mycobacterium tuberculosis (Mtb), and the Alr and YlmE proteins from Streptomyces coelicolor A3(2).Mtb is the main cause of tuberculosis.
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Corpora Non Agunt Nisi Fixata: Ligand Receptor Binding Kinetics in G Protein-Coupled Receptors
The present thesis focuses on the pharmacological concept of drug-target interaction, which dates back to the beginning of modern pharmacology.
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The structure of a working catalyst: from flat surfaces to nanoparticles
Promotor: Prof.dr. J.W.M. Frenken
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Clavis Aurea? Structure-enabled approaches of identifying and optimizing GPCR ligands
Promotores: A.P. IJzerman, H.W.T. van Vlijmen
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Development of kinase inhibitors and activity-based probes
Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt
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Lipid bilayers decorated with photosensitive ruthenium complexes
Promotor: Prof.dr. E. Bouwman, Co-promotor: S. Bonnet
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Bioorthogonal tools to study fatty acid uptake in immune cells
The cellular metabolism of immune cells constitutes an important part of their proper function and activation. Using T cells as an example, this phenomenon is highlighted by the metabolic reprogramming that occurs in these cells upon activation.
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Management of Small-Scale Fisheries at the Elephant Marsh in Malawi
Wetlands provide many ecosystem goods and services which include fish production. The sustainability of small-scale fisheries (SSF) has received considerable attention in recent years because fish is one of the major sources of animal protein to a considerable fraction of the global population which…
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Huid verdedigt zichzelf tegen schadelijk zuurstof
Zuurstof is essentieel voor ons om te leven. Maar zuurstof kan, in de vorm van reactieve moleculen, ook schadelijk zijn. Gelukkig bevat de buitenste laag van onze huid antioxidanten die de meeste schadelijke zuurstof direct uitschakelen, zo ontdekten Leidse chemici. Hun resultaten staan beschreven in…
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Online Proefstuderen | 13 Oktober 2023
Leiden University College The Hague (LUC) biedt een 3-jarige bacheloropleiding aan waarin je je focust op Global Challenges; grote uitdagingen waar de mensheid mee te maken heeft: Vrede & Rechtvaardigheid, Diversiteit, Duurzaamheid en Welvaart. Je hebt ruimte om de opleiding zo in te richten als je…
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Crisisbeheersing
Publicaties Opleiden, trainen, oefenen en leren in crisisbeheersing en rampenbestrijding
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Saskia als Flora
Rembrandt schilderde deze Flora, de Romeinse godin van de lente, in 1634. De voorstelling is te zien bij het poortgebouw met daarachter de weelderige flora van de Hortus botanicus van de universiteit. Ongetwijfeld kende Rembrandt, die bijzondere naturalia verzamelde, de Leidse Hortus van nabij. Deze…
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Corruption & Integrity in the Netherlands (1945 - present)
Corruption, integrity (or a lack thereof…) and public values are near omnipresent elements in public administration and politics of all times. Cases of corrupt public officials and politicians continuously emerge. Strangely enough, however, it often remains unknown what actually occurred, how something…
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Online Proefstuderen | 13 Oktober 2023
Leiden University College The Hague (LUC) biedt een 3-jarige bacheloropleiding aan waarin je je focust op Global Challenges; grote uitdagingen waar de mensheid mee te maken heeft: Vrede & Rechtvaardigheid, Diversiteit, Duurzaamheid en Welvaart. Je hebt ruimte om de opleiding zo in te richten als je…
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Core cross-linked polymeric micelles based on polypept(o)ides: from secondary structure formation of polypeptides to functional cross-linking
This thesis aimed to investigate core cross-linked polymeric micelles (CCPMs) and expand their potential for the delivery of hydrophobic drugs and co-factors.
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Chemische verbinding beïnvloedt afweersysteem
Chemici, waaronder Sander van Kasteren en Hermen Overkleeft, hebben ontdekt dat azides, een bepaalde chemische verbinding, specifieke T-cellen kunnen laten reageren op een vaccin of juist het vaccin kunnen laten negeren. Publicatie in Angewandte Chemie.
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Crowdfundingsactie 'Een tuintje op Mars' van start
Dertien Leidse studenten zijn een crowdfundingsactie gestart om geld in te zamelen voor onderzoek naar mogelijkheden om planten op Mars te verbouwen. Zij dragen hiermee bij aan de kennis van het heelal. Het project maakt deel uit van de iGEM-wedstrijd.
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Health, Disadvantage and the Welfare State
Promotie
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Eerste onderwijspracticum in gloednieuwe labs
Een primeur voor zo’n 150 studenten Life Science & Technology: het eerste practicum in de gloednieuwe laboratoria van het nieuwe Gorlaeus Gebouw van de Faculteit der Wiskunde en Natuurwetenschappen.
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The power of one qubit in quantum simulation algorithms
Quantum computing is an emerging technology, which holds the potential to simulate complex quantum systems beyond the reach of classical numerical methods.Despite recent formidable advancements in quantum hardware, constructing a quantum computer capable of performing useful calculations remains challenging.In…
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Low energy electron transmission through layered materials and chiral organic films
In this Ph.D. thesis we study the interaction of low energy electrons with thin materials, namely layered materials (graphene, hexagonal boron nitride, molybdenum disulfide) and organic films. At these low energies the quantum mechanical wavelength of the electron wave function is in the order of a…
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Play by the rules? : coordination of EU sustainable development policies and the importance of the politico-legal context
There is an increasing amount of attention on EU and its Member States contributions to implementation of two landmark agreements: the Paris Climate Agreement and the UN Agenda 2030 with Sustainable Development Goals (SDGs). Absent from the current literature is an analysis of the political effect of…
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Merging galaxy clusters: probing magnetism and particle acceleration over cosmic time
In this thesis, I studied the origin and evolution of the non-thermal radiation in merging galaxy clusters.
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Satellite remote sensing of plant functional diversity
Biodiversity enables ecosystems to thrive through the synergy of functional differences among organisms. While human well-being strongly depends on biodiversity-driven ecosystem services, human actions are also at the root of current unprecedented biodiversity declines.
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Dark ice chemistry in interstellar clouds
This thesis is largely an experimental study on the formation of solid-state simple and complex organic molecules in the H2O-rich and CO-rich ice phases of dense interstellar clouds and dark cores.
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Externe onderzoekssamenwerking
Binnen het brede netwerk van de Universiteit Leiden neemt het instituut deel aan onderzoek binnen de volgende profileringsgebieden:
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Over ons
Door haar activiteiten, draagt het Europa Instituut bij aan het begrip en de ontwikkeling van de snel evoluerende integratie in Europa.
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Integrating Analytics with Relational Databases
The database research community has made tremendous strides in developing powerful database engines that allow for efficient analytical query processing.
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Galaxy formation traced by heavy element pollution
Galaxies form and evolve through close interaction with their surroundings. As a result, the heavy elements ('metals') that are synthesized in stars, are found both inside and outside galaxies.
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Maak het Groninger model voor mijnbouwschade algemeen geldend
In dit artikel onderzoeken Gerrit Dijkstra en Frits van der Meer de huidige afhandeling van mijnbouwschade in Nederland
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Where photons meet phonons
We investigate how radiation pressure can be used to influence the mechanical motion of a micro-mirror suspended from springs.
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Optimization of quantum algorithms for near-term quantum computers
This thesis covers several aspects of quantum algorithms for near-term quantum computers and its applications to quantum chemistry and material science.
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Non-Abelian metamaterials: emergent computing and memory
In the traditional theory of linear elasticity, superposition dictates that the response of a material does not depend on the sequence of the applied mechanical actuations.
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Paul Scholten. Book chapter in Great Christian Jurists in the Low Countries
Timo Slootweg, associate professor at he department Philosophy of Law, published a chapter about Paul Scholten in
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Gorlaeus Gebouw
Universiteit Leiden realiseert een nieuw en duurzaam gebouw met state of the art onderzoek –en onderwijsfaciliteiten voor de Faculteit der Wiskunde en Natuurwetenschappen, het Gorlaeus Gebouw. Het ontwerp van dit gebouw, middenin het hart van de Science Campus en het Leiden Bio Science Park, stimuleert…
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Natural and non-natural factors influencing Alzheimer´s Aβ
Promotor: Prof.dr. J.P. Abrahams