This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

Kinase inhibitors are key therapeutic agents, particularly in oncology, yet their clinical efficacy is often hampered by off-target effects and limited understanding of their cellular target profiles.

Interactive exploration of large volumes of data is increasingly common, as data scientists attempt to extract interesting information from large opaque data sets. This scenario presents a difficult challenge for traditional database systems, as (1) nothing is known about the query workload in advance,…

The department of Industrial Ecology is dealing with research into the development of tools for decision making on sustainable production and consumption.

Catalysis is of extreme relevance in the production of everyday materials and plays a central role in many aspects of our life.

Humanity stands at a pivotal juncture, facing the dual challenge of environmental sustainability and rapid population growth, projected to exceed 11 billion by century’s end.

Promotor: Prof.dr. M. Danhof, Co-Promotor: J. de Jongh

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman

This thesis seeks to combine two different research topics; Multi-Objective Optimization and Complex Network Analysis.

De Academy of Creative and Performing Arts biedt in samenwerking met een aantal instellingen voor hoger onderwijs in de kunsten, twee PhD-programma’s aan: in de muziek (docARTES) en de beeldende kunst en vormgeving (PhDArts). Deze programma's zijn beide internationale doctoraatsprogramma's voor praktijkgericht…

Onze AI-wetenschappers werken nauw samen met onder andere de TU Delft en de Erasmus Universiteit.

This thesis describes the design and synthesis of fragments of various cell wall carbohydrates of the Streptococcus species, including the branched Group B-specific antigen (GBC) of Group B Streptococcus, glycerol phosphate (GroP) modified group A carbohydrate (GAC), and the O-acetylated type 1 capsular…

Onderzoek aan LUC past binnen het algemene kader van de wereldwijde uitdagingen die centraal staan in ons onderwijsprogramma. Het richt zich op belangrijke maatschappelijke vraagstukken, waaronder Vrede & Recht, Diversiteit, Welvaart en Duurzaamheid.

Ben jij een nieuwsgierige en enthousiaste student en wil je meer naast je studie doen? Dan is het honoursonderwijs misschien wel iets voor jou.

Sepsis is a life-threatening condition caused by a dysregulated host response to infection, it is associated with significant morbidity, mortality, and with a high financial burden on global healthcare systems. Bacterial infections are the primary cause of sepsis, but the growing prevalence of antimicrobial…

Molecular materials have been a subject of interest in fundamental research and applications for decades, and have been studied as bulk crystals, (thin) films and as individual molecules, due to the large variety in their properties. This dissertation explores pentacene crystals near the two-dimensional…

Materials with strongly correlated electrons show some of the most mysterious and exotic phases of quantum matter, such as unconventional superconductivity, quantum criticality and strange metal phase.

Ben jij een nieuwsgierige en enthousiaste student en wil je meer naast je studie doen? Dan is het honoursonderwijs misschien wel iets voor jou.

Benieuwd wat de bachelor opleiding Kunstgeschiedenis inhoudt? We vertellen je er alles over in de opleidingsvideo.

More than 5,000 exoplanets have been found over the past couple of decades. These exoplanets show a tremendous diversity, ranging from scorching hot Jupiters, common super-Earths, to widely separated super-Jupiters on the planet/brown dwarf boundary.

Promotor: Prof.dr. J.N. Kok, Co-Promotor: W.A. Kosters

This Thesis focuses on the design and synthesis of ADP-ribosylated compounds that can be applied in biological studies.

Human language is constantly evolving with its linguistic structure being shaped by language users at both individual and population levels. Focusing on the interplay between processes of language acquisition and communicative need in shaping human languages, this thesis introduces a novel computational…

Welke rol spelen stress en angst bij de vorming van nocebo hyperalgesie?

This thesis investigates innovative and classical strategies in glycoconjugate vaccine development to address the growing threat of multidrug-resistant bacterial infections.

Dr. Els de Busser, assistent-professor en onderzoeker aan het Institute of Security and Global Affairs, heeft als hoofdonderzoeker van een consortium 1,45 miljoen euro gekregen voor een project genaamd C-SIDe.

Op 23 juni 2020 verdedigde Santy Kouwagam haar proefschrift 'How lawyers win land conflicts for corporations: Legal Strategy and its influence on the Rule of Law in Indonesia'. Het promotieonderzoek is begeleid door promotoren prof.dr. A.W. Bedner en prof.dr. C.E. von Benda-Beckmann.

The first direct detection of gravitational waves opened the possibility of mapping the Universe via this new and independent messenger.

Promotor: Prof.dr.ir. J.G.E.M. Fraaije, Co-promotor: A. Kros

A new type of tripodal squaramide-based supramolecular hydrogels is developed and studied.

Promotores: Prof.dr. C.U. Keller, Prof.dr. H.C. Gerritsen

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

The aim of this thesis is to develop and study a robust and adaptable scaffold for supramolecular polymer self-assembly in water.

This dissertation contains four works during my PhD. Different biomaterials have been designed based on coiled-coil peptides. These biomaterials have a range of applications, inclusing drug delivery, cell sorting to cell-cell fusion.

With an emphasis on developing novel miktoarm star polymers termed PeptoMiktoStars, this thesis leverages asymmetric polymeric polypept(o)ide frameworks to advance their effectiveness in delivering hydrophobic drugs and nucleic acids.

This thesis mainly focuses on cross-modal retrieval and single-modal image retrieval via deep learning methods, i.e. by using deep convolutional neural networks.

Supply risks are not new. But the aggravation of power conflicts on the international stage coupled with global shifts towards energy transition and digitalization has triggered the next supply risk research era.

Promotor: F. Arbab, R. De Nicola, Co-Promotor: M. Tribastone

Promotor: Prof.dr. J.P. Abrahams

This thesis explores interfacial conductance and electric field-effects in LaAlO3/SrTiO3 heterostructures.

When a star is born in our Galaxy, it is quite likely that it has formed within a massive cluster, which hosts numerous high-mass stars bathing their lower mass neighbours in UV radiation.

This thesis aims to test in vitro pipelines to rapidly and cost-effectively identify molecular mechanisms that drive adverse outcomes in clinical use.

It researches (the possibilities for) the development of a set of principles and best practices for insolvency office holders by comparing multilateral treaties and soft law recommendations and national legislation within Europe.

How and to what extent the historic house (re-)constructs identity through image-making in China.

What is the effect of light at night on plant phenology and physiology, and how does this affect plant interactions with other species?