Decentralized plug and play systems for energy production are the future picture of our society. Artificial photosynthetic systems are used for this purpose.

De verduurzaming van de openbare ruimte op de campus krijgt veel aandacht in dit project. Het wordt een aangename, groene verblijfsplek waar je kunt ontspannen en koelte kunt vinden op warme dagen.

Promotores: Prof.dr. C.A.J. Knibbe, Prof.dr. M. Danhof, Prof.dr. K. Allegaert (Leuven)

FSW-gebouw, Wassenaarseweg 52, 2333 AK, Leiden

An Active Galactic Nucleus (AGN) is a highly luminous region at the center of a galaxy, powered by the accretion into a supermassive black hole and emitting energy from radio waves to gamma rays, often outshining the host galaxy.

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

Barrier function is the natural role of the skin. The lipid matrix present in the outermost layer of the skin, the stratum corneum is important for this function.

In this thesis, we aimed to better understand the underlying mechanisms involved in TNBC progression and metastasis formation and discover new targets to reduce breast cancer related deaths.

Planets are formed in disks of gas and dust around young stars.

Democratie begint bij de gemeente. Daar ligt de bron van burgerschap, zeker in Nederland, zo schrijven Wim Voermans en Geerten Waling in het boek Gemeente in de genen, dat 20 februari verschijnt bij uitgeverij Prometheus.

Microben, dat zijn toch ziekmakers? Moeten we daar niet vanaf? Nou, liever niet, weet microbioloog Ben Lugtenberg. Zonder microben gaan we namelijk dood. Na zijn eerste boek 'Zó leuk is microbiologie' is er nu 'Gezond met microben'. Voor dit boek heeft hij 35 expert gevraagd iets te schrijven over…

Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.

Developing new medicines is one of modern science's most significant hurdles, a process marked by high costs, long timelines, and frequent failures of promising candidates.

Promotor: Prof.dr. E Gittenberger, Co-Promotores: C.H.J.M. Fransen, B.W. Hoeksema

Promotor: Prof.dr. B. van de Water

Chemical-induced organ toxicity is a major concern in the development and use of chemicals, including drugs, pesticides, industrial chemicals and cosmetics. In the last decades, the onset and progression of chemical-induced organ toxicity has been linked amongst others to perturbation of mitochondri…

Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.

Epithelial-mesenchymal plasticity (EMP) and tumor cell migration play an important role in cancer progression, and an improved understanding of the mechanisms underlying these concepts is essential for developing new targeted approaches.

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

Promotor: B. van de Water

Advanced sensing techniques require graphene with high quality and well-controlled surface chemistry.

The aromatic infrared bands (AIBs) seen throughout the interstellar medium (ISM) are generally thought to be carried by polycyclic aromatic hydrocarbons (PAHs) and their nitrogen analogues (PANHs).

Promotor: Prof.dr. B. van de Water

Promotores: Prof.dr. G.W. Canters, Prof.dr. T.J. Aartsma

Promotores: B. van de Water; P. Hogendoorn; J. Bovée Co-Promotor: E.H.J. Danen

Immunotherapies for cancer are an emerging class of therapeutic strategies which aim to treat cancer via augmentation of the immune system.

Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.

Promotor: E.F. Smets Co-promotor: J. Geml

Promotor: E. Gittenberger, Co-promotores: L.P. van Ofwegen; B.W. Hoeksema

The focus of the described research in this thesis is on the oxidative stress response (Nrf2 pathway). The aim of the research presented in this thesis is to obtain more information concerning microRNAs which are involved in the Nrf2 pathway, to determine and evaluate the application of microRNAs for…

Cardiovascular diseases (CVDs) are the leading global cause of mortality. Endothelial dysfunction, an early reversible stage of CVD development, is marked by decreased nitric oxide production linked to Ca2+ influx in endothelial cells.

My PhD thesis investigates the ecological significance of resistance against drought-induced air bubble formation inside the water conduits of plants (embolism), and the plasticity and functional aspects of stem anatomical traits in woody and herbaceous species.

Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.

Promotor: B.van de Water, Co-promotor: L.S.Price

Sustainable energy from wind and solar is most readily available near the sea.

Dissolving microneedles are a subgroup of microneedle types that completely dissolve within the skin. During this dissolving process the vaccine, stored in the needle matrix, is released into the skin.

Promotor: J. A. Bouwstra

Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.

Streptomyces are bacteria abundant in soil that participate in diverse and complex interactions. These bacteria are the main producers of the antibiotics we currently use in the clinic.

The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.

Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis

Hoe helpen demonstratie-experimenten in de klas leerlingen om te leren chemisch redeneren?

Dit onderzoek gaat over het gebruik en de interpretatie van hoeveelheidsuitdrukking in verschillende talen, met name in relatie tot telbaarheid.

This thesis investigates catalytic reactions at the atomic scale using scanning tunneling microscopy (STM), with a focus on Fischer–Tropsch synthesis, a key industrial process that converts hydrogen and carbon monoxide into liquid fuels.

Als onderdeel van de Leidse Erfgoed Deal werkt de Gemeente Leiden samen met de Universiteit Leiden, Naturalis Biodiversity Center en Erfgoed Leiden en Omstreken aan onderzoek naar de klimaatopgave voor de binnenstad en de historische groen- en blauwstructuren. Het doel is om te verkennen hoe deze structuren…

Dit proefschrift onderzoekt hoe golven zich gedragen in een imperfecte omgeving. Denk aan een golf op het wateroppervlak na een passerende boot: ook als de boot al lang weg is, blijft de golf nog een tijd zichtbaar. Maar wat gebeurt er als de golf realistische oneffenheden of verstoringen tegenkomt?

collegereeks duurzaamheid en recht

Die vervelende regendruppels die voor een nat pak zorgen, ontstaan ergens in de lucht uit wolken van waterdamp. Het proces nucleatie beschrijft de manier hoe dit gebeurt. Edgar Blokhuis van het Leids Instituut voor Chemie ontwikkelde een theorie om dit overgangsproces nauwkeuriger te beschrijven. Scheikundigen…