2,156 zoekresultaten voor “aging software development” in de Publieke website
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Buitenlandse studenten van start met bijwonen Opening Academisch Jaar
Honderden nieuwe studenten van de Universiteit Leiden woonden de opening van het academisch jaar 2015-2016 bij. Ze kwamen uit alle hoeken van de wereld naar Leiden voor de start van een nieuwe studie. Portretten van nieuwkomers.
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Structured Parallel Programming for Monte Carlo Tree Search
The thesis is part of a bigger project, the HEPGAME (High Energy Physics Game). The main objective for HEPGAME is the utilization of AI solutions, particularly by using MCTS for simplification of HEP calculations.
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Gestandaardiseerde en reproduceerbare meting van besluitvaardigheid bij muizen
In de wetenschap is het van vitaal belang dat meerdere studies hetzelfde resultaat onderschrijven. Onderzoekers moeten daarom alle details van eerdere experimenten kennen om de procedures zo exact mogelijk uit te kunnen voeren. Dit is echter een steeds groter probleem in de neurowetenschappen. Het is…
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Projecten
Het CLEI initeert projecten op gebied van ondernemerschap en innovatie ten behoeve van studenten. We werken daarbij graag samen met organisaties in het werkveld. De enige voorwaarde is dat de juridische dienstverleners, innovatie adviseurs, technologische bedrijven zich openstellen voor de samenwerking…
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Citizen science
Citizen science of burgerwetenschap is een term die recentelijk veel wordt gebruikt, maar wat houdt het precies in? Wat is het verschil tussen tussen citizen science en crowdsourcing? En hoe verhoudt community archaeology/gemeenschapsarcheologie zich hiermee?
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Vineland II
Studieondersteuning, Loopbaanontwikkeling, Communicatie, Persoonlijke ontwikkeling
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[sbb] INSCONS: International Scientific Consortia
Wereldwijde uitdagingen aanpakken via internationale wetenschappelijke consortia
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Population-Scale Network Analysis (POPNET)
Een infrastructuur voor onderzoeksdata in computationele sociale wetenschappen
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Vertalingen & tekstcorrecties
De vertaalafdeling van het Academisch Talencentrum heeft ruime ervaring met vertaalwerk van het Nederlands naar het Engels en van het Engels naar het Nederlands. Onze werkwijze kenmerkt zich door professionaliteit, kwaliteit en betrouwbaarheid.
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Over de opleiding
Bij de bachelor Informatica in Leiden leer je alles over de werking van computers, algoritmen en data. Je ontdekt hoe je op een wetenschappelijke manier alledaagse problemen oplost met behulp van software en technieken op het gebied van machine learning. De opleiding heeft een duidelijk bèta karakter,…
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Stap 3: gebruiken
Hoe kun je de gevonden informatie gebruiken?
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LLInC Studio
De interactieve studio voor media en simulaties, ontworpen en gebouwd door ons in-house team.
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Introduction to Network Theory Using Gephi
Workshop
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Expanding the coverage of ecosystem services in life cycle assessment: an interdisciplinary venture
To contribute to the body of knowledge aiming at a better coverage of ecosystem service assessment in LCA studies, this thesis dives into the challenges of incorporating existing ecosystem service methods within the impact assessment phase of the conventional LCA framework.
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Computed fingertip touch for the instrumental control of musical sound with an excursion on the computed retinal afterimage
Promotor: Prof.dr. S. Haring
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Improving targeted gene editing in Arabidopsis thaliana
Understanding DNA repair mechanisms is essential for advancing plant biotechnology and crop improvement. This study investigates how double-strand breaks (DSBs), induced by CRISPR/Cas systems, are repaired in the model plant Arabidopsis thaliana, and how these processes influence Agrobacterium tumefaciens…
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Identification and characterization of developmental genes in streptomyces
Promotor: Prof.dr. G.P. van Wezel
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Towards a system-based pharmacology approach to predict developmental changes in renal drug clearance in children
Promotores: Prof.dr. C.A.J. Knibbe, Prof.dr. M. Danhof, Prof.dr. K. Allegaert (Leuven)
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A novel formulation for skin barrier repair : from ex vivo assessment towards clinical studies
The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.
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Breaking the witches' spell: towards steering the soil microbiome for volatile-mediated control of the root parasitic weed Striga
Striga hermonthica, commonly known as witchweed, infests major cereal crops in Sub-Saharan Africa causing severe yield losses and threatening the livelihood of millions of resource poor farmers.
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Click-to-release for immune cell activation
This work describes the use of click-to-release chemistry to get spatiotemporal control over immunocytokine activity. Until now, immunocytokines (cytokines coupled to a tumor-targeting-moiety) remained active throughout the body, being able to bind their respective receptors, causing mild to severe…
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Business incubators: the impact of their support
A New Technology-Based Firm (NTBF) is a significant enabler of job creation and a driver of the economy through stimulating innovation.
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Duurzaamheid in onderwijs
In het onderwijs bieden wij alle studenten de mogelijkheid om kennis te maken met duurzaamheidsthema’s en –vraagstukken, waar mogelijk aansluitend bij de inhoud van hun opleiding.
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Structural characterization of the cell envelope of Actinobacteria under changing environments
Bacteria have the ability to alter their morphology in order to adapt to changing environments.
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Bioorthogonal Labeling Tools to Study Pathogenic Intracellular Bacteria
In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.
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Withstanding the cold: energy feedback in simulations of galaxies that include a cold interstellar medium
Understanding how galaxies form, interact, and evolve comes largely from comparing theory predictions with observational data. Numerical simulations of galaxies provide the most accurate approach to testing the theory, as they follow the non-linear evolution of gas and dark matter in great detail and…
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Mast cells as immune regulators in atherosclerosis
Cardiovascular syndromes are the major cause of death in Western societies.
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Analytical chemistry and biochemistry of glycosphingolipids: new developments and insights
Advanced mass spectrometry of glycosphingolipids takes the central stage in this thesis. Investigations focus on characterization of glycosphingolipid metabolism in health and disease with emphasis to the detection and accurate quantitation of known and so far unknown glycosphingolipids and closely…
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Microengineered Human Blood Vessels For Next Generation Drug Discovery
Heart failure is a major health care problem with high mortality.
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Quantitative modelling of the response of earthworms to metals
Promotor: Prof.dr. W.J.G.M. Peijnenburg
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The developing infant gut microbiota: mathematical predictions of the effects of oligosaccharides
A complex community of microbes develops in the infant gut shortly after birth. We call this community the infant gut microbiota. The microbiota influences the health of the infant, which makes the composition and function of the infant gut microbiota an important topic to study.
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Visual analytics for spatially-resolved omics data at single cell resolution: Methods and Applications
The deeper understanding of an organism's pathology is important for developing treatments. Over centuries of systematic research, clinical researchers have demonstrated that the more information they acquire about the cellular properties and their organisation in the tissue, the better they can understand…
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De negatieve gevolgen van pesten
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Onderwijs
MCS, en het onderzoek dat door ons gedaan wordt, heeft sterke banden met de twee Leidse masterspecialisaties op het gebied van museum studies; bij de opleiding Kunstgeschiedenis en bij Archeologie.
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Activity-based protein profiling of glucosidases, fucosidases and glucuronidases
Promotores: H.S. Overkleeft, G.A. van der Marel, Co-promotor: B.I. Florea
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Caging ruthenium complexes with non-toxic ligands for photoactivated chemotherapy
The main goal of the research described in this thesis was the development of new photoactivated chemotherapy (PACT) ruthenium(II) complexes bearing a non-toxic photolabile ligand.
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CellEKT: a chemical proteomics platform to study the kinome
Kinase inhibitors are key therapeutic agents, particularly in oncology, yet their clinical efficacy is often hampered by off-target effects and limited understanding of their cellular target profiles.
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Design and Synthesis of Immunomodulatory Peptide Conjugates
This dissertation explores new chemical strategies for the synthesis of self-adjuvanting peptide conjugates and immunomodulatory ligands aimed at targeted activation of the immune system.
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Phanta Rhei: recht en duurzaamheid
In deze bundel wordt verslag gedaan van onderzoek op het gebied van duurzaamheid, uitgevoerd aan de Leidse rechtenfaculteit.
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High-contrast imaging polarimetry of exoplanets and circumstellar disks
Understanding the formation and evolution of planetary systems is one of the most fundamental challenges in astronomy. To directly image and study young exoplanets and the circumstellar disks they form from, dedicated high-contrast imaging instruments are built.
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Towards a Relational Approach to Understanding Interactions in Interactive Art
This thesis introduces a relational interaction model and a practical tool for describing, visualising and generating interactive dialogues.
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Systems pharmacology of the amyloid cascade
According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).
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Optimisation of first clinical studies in special populations: towards semi-physiological pharmacokinetic models
M. Danhof, Co-promotores: J. Freijer, A. Yassen
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Evolutionary adaptability of β-lactamase: a study of inhibitor susceptibility in various model systems
β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…
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Lipids as therapeutic targets for barrier repair in skin diseases
The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.
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Advancing the LeiCNS-PK3.0 model for prediction of CNS Pharmacokinetics Nonlinear BBB Transport, Inter-species Scaling, and Machine Learning
This thesis focuses on enhancing predictions of central nervous system drug exposure using the LeiCNS-PK3.0, a physiologically based pharmacokinetic model.
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The impact of climate variability on the ecology of a lion (Panthera leo Linnaeus 1758) population and lion livestock conflicts in the Amboseli
Promotor: Prof.dr. G.R. de Snoo, Prof.dr. G.A. Persoon, Co-promotor: H.H. de Iongh
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Aria of the Dutch North Sea
Promotores: C. J. ten Cate; M. A. Ainslie. Co-promotor: W. Slabbekoorn
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Focal-plane wavefront sensors for direct exoplanet imaging: Theory, simulations and on-sky demonstrations
One of the key limitations of the direct imaging of exoplanets at small angular separations are quasi-static speckles that originate from evolving non-common path aberrations (NCPA) to which the primary adaptive optics system is inherently blind. The main focus of this thesis is the development and…
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The lead zeppelin: a force sensor without a handle
Promotor: T. H. Oosterkamp