In het onderzoeksprogramma Drug Discovery & Safety zijn we geïnteresseerd in de werkzaamheid en veiligheid van nieuwe medicijnen en nieuwe manieren om deze aspecten te bepalen. Daarvoor combineren we geavanceerde imaging en high-throughput screening technieken met computationele aanpakken zoals chem-…

Exploring metabolomics-based biomarkers for diagnosis and treatment response monitoring of community-acquired pneumonia

The cannabinoid receptor type 2 (CB2R) is associated with several inflammatory diseases with an unmet medical need (e.g. Alzheimers, multiple sclerosis, reumatoid arthritis). Development of new chemical biology strategies to study this protein is essential to aid future development of drugs for these…

Hieronder vind je een overzicht van de publicaties van LAPP.

Orthopedagogen Adriana Bus, Carienke Kegel en Heleen van den Berg hebben van de gemeente Leiden een subsidie van €120.000 gekregen voor het project ‘De eerste 30 miljoen woordjes’. Met dit project willen zij het taalaanbod dat jonge kinderen krijgen, verbeteren.

The mission of our group is understanding how science communication works to improve the interaction between science and society. We believe better science communication can improve our society and engage many different groups with science, also improving science.

Our recent excavations have focused on the more recent New Kingdom/Late Period (ca. 1500-332 BCE) material.

This thesis investigates opinion dynamics on random graphs through the lens of the voter model, a classical interacting particle system used to describe how consensus emerges in networks.

Promotor: Prof.dr. P.G.L. Klinkhamer, Co-Promotor: T.J. de Jong

Promotor: K.J. Batenburg, Co-promotor: A.W. van der Vaart, B. de Smit

It has now been well established that shocks and turbulent motions in the intra-cluster medium (ICM) generated through cluster mergers can produce large-scale synchrotron emission.

Large carnivores and humans, along with their livestock, have co-existed for thousands of years. However, human population growth and an increase in economic activities are modifying the landscape for large carnivores and their prey.

The endocannabinoid receptors CB1R and CB2R are involved in a plethora of processes, and consequently are involved in many pathological conditions. Their wide distribution makes the CBRs both an interesting therapeutic target and hard to study.

Promotor: Prof.dr. I.A.G. Snellen, C.U. Keller

This thesis seeks to combine two different research topics; Multi-Objective Optimization and Complex Network Analysis.

Promotor: R. Verpoorte, Co-promotores: Y.H.Choi, N.R. Mustafa

Are you planning to conduct clinical research in the Netherlands? In this online course, you are introduced to legislation and procedures on clinical research in the Netherlands. It will help you prepare and submit your research file efficiently. The first three themes ‘The Dutch Review System’ , ‘The…

Image-Pro Plus, ImageJ, Cell Profiler, R, Knime en NIS-elements

Despite their ecological, cultural, and economic importance, lion (Panthera leo) populations in Kenya are declining rapidly due to retaliatory killings following livestock depredation, depletion of wild prey, habitat loss driven by human activities, climate change, and disease.

The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…

Promotor: A.P. IJzerman Co-promotor: L.H. Heitman

Promotores: Prof.dr. T.H.W. Bäck, Prof.dr. M.R.V. Chaudron, Co-Promotor: M.T.M. Emmerich

A difficulty of studies on chemical kinetics are the reaction time scales and detection of their intermediates.

This dissertation explores how we can make anomaly detection—identifying unusual or faulty behavior in complex systems—more trustworthy and effective, with a focus on smart manufacturing.

Promotor: Prof.dr. E. Bouwman, Co-promotor: S. Bonnet

Promotores: Prof.dr. H.J.M. de Groot, Prof.dr. J. Matysik (Universitaet Leipzig)

The intradermal administration route is attractive for vaccine delivery, because of the highly populated antigen-presenting cells in the skin. However, the skin’s main physical barrier, the stratum corneum, prevents vaccines from entering the skin.

Het onderzoek binnen de Faculteit der Wiskunde en Natuurwetenschappen omvat de disciplines wiskunde, informatica, sterrenkunde, natuurkunde, scheikunde, bio-farmaceutische wetenschappen, biologie en milieuwetenschappen.

Promotor: P. Stevenhagen, Co-promotor: R.M. van Luijk

Ontdek de cursus Communicating in Legal English van de Leiden Law Academy en verbeter uw juridisch Engelse vaardigheden. Lees hier meer!

Webinar with Q&A

Kunst en vrije tijd, Kunst en vrije tijd

The study of orchid flowers, fruits, and inflorescences is crucial due to the remarkable diversity of orchid species and their unique adaptations to pollinators and seed dispersers. However, our understanding of the evolution and development of these organs within the orchid family remains limited.

The plant hormone auxin regulates plant growth and development through polar cell-to-cell transport-generated maxima and minima. PIN FORMED (PIN) auxin efflux carriers determine the direction of this auxin flow through their asymmetric placement on the plasma membrane (PM).

Natural history collections provide invaluable sources for researchers with different disciplinary backgrounds, aspiring to study the geographical distribution of flora and fauna across the globe as well as other evolutionary processes.

In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.

In this thesis, the research focuses on the properties of dark matter and dark matter haloes and how they connect with the galaxies we can observe in the Universe.

Promotor: Prof.dr. E.F. van Dishoeck

Promotor: Prof.dr. B. van de Water

Promotoren: R. Tijdeman, A.K. Lenstra, Co-promotor: H.J.J. te Riele

Galaxy intrinsic alignments induce a major astrophysical contamination to weak gravitational lensing measurements and need to be modelled and mitigated when extracting cosmological information from such measurements.

Promotor: I. A. G. Snellen, Co-promotor: M. A. Kenworthy

This dissertation studies the Asymptotics of Bayesian nonparametric inference for Gaussian linear models.

Promotores: K.J. Batenburg, B. Koren

Outflows are crucially important for the gas budget and evolution of luminous star-forming galaxies and AGNs, with observed mass outflow rates of the same order as the star formation rate. Greater star formation and black hole growth lead to more intense feedback and outflows, resulting in self-regulated…

Promotores: W. Th. F. den Hollander, M.O. Heydenreich

Classical statistical methods, such as p-values, are difficult for researchers to apply correctly. They for example do not allow drawing conclusions from a study early, or for extending a study with extra research groups that want to make their data available later.

Low-mass main-sequence stars like our Sun are continuous sources of outflowing hot magnetised plasma. In the case of the Sun, this is known as the solar wind, whereas for other stars they are called stellar winds.

Promotores: P. Stevenhagen, A. Enge Co-Promotor: T.C. Streng

We have conducted a full spectral line survey of the 3-13 micron region of two massive protostars, AFGL 2591 and AFGL 2136, for the first time at high spectral resolution.