In this thesis new methodologies are developed for the detection and systematic study of radio sources in the early universe. This allows us to gain a deeper understanding of the formation and evolution of galaxies, the activity of supermassive black holes, and the final phase transition of our universe:…

The ideas underlying this thesis are that lipidomics may improve the diagnosis of liver metabolic diseases, and can provide further insights into the underlying pathophysiology of these diseases.

Over the past years it has been discovered that the population of extra-solar planets is large and diverse.

Almost all bacteria are enveloped by a cell wall that provides cellular protection.

Zowel met spel als politiek kunnen werelden worden geschapen waarin nieuwe regels gelden, betekenissen worden gecreëerd en mogelijkheden ontstaan voor samenwerking, strategie en creatieve oplossingen. In die zin hebben spel en politiek altijd veel gemeen gehad. Maar wat gebeurt er met deze verwantschap…

Promotors: Prof.dr. E. Bouwman, Prof.dr. E. Drent

Quantum computing is an emerging technology, which holds the potential to simulate complex quantum systems beyond the reach of classical numerical methods.Despite recent formidable advancements in quantum hardware, constructing a quantum computer capable of performing useful calculations remains challenging.In…

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Onderzoekers aangesloten bij het Leiden Leadership Centre zijn actieve leden van het PUPOL netwerk. PUPOL is een internationaal academisch netwerk voor publiek en politiek leiderschap. Dit netwerk stimuleert de uitwisseling van ideeën en bevordert gezamenlijk onderzoek tussen wetenschappers gericht…

The intracluster medium (ICM) is a hot, tenuous and X-ray emitting gas that pervades galaxy clusters.

Endocannabinoids are lipid messengers that modulate various physiological functions by activating the cannabinoid CB1 and CB2 receptors. While the metabolism of endocannabinoids and their action at the CB receptors is fairly well studied, the molecular mechanisms governing their release and transport…

This thesis mainly focuses on cross-modal retrieval and single-modal image retrieval via deep learning methods, i.e. by using deep convolutional neural networks.

Dissochaeta Blume (Melastomataceae, tribe Dissochaeteae) is well-known as a scrambling plant genus found in Southeast Asia, where it is an inhabitant of the tropical rainforests or evergreen forests.

Protoplanetary disks are the gas and dust environments where planetary systems form around young stars. Using observations from the Atacama Large Millimeter/submillimeter Array (ALMA) this thesis analyses the gaseous molecular reservoir, using multiple tracers to resolve the 3D structure of protoplanetary…

Explaining treatment response variability between and within patients can support treatment and dosing optimization, to improve treatment of individual patients.

This thesis provides explicit expressions for the density functions of absolutely continuous invariant measures for general families of interval maps, that include random maps and infinite measure transformations, not necessarily number systems.

When a star is born in our Galaxy, it is quite likely that it has formed within a massive cluster, which hosts numerous high-mass stars bathing their lower mass neighbours in UV radiation.

This thesis advance our understanding and the application of molecular catalysts relevant to the reduction of oxygen as well as reduction of nitrite.

Promotor: Prof.dr. H.L.V. Linnartz

Promotor: K.H. Kuijken

In this thesis, we have studied cell images from two types of cells, including pollen grains and the immune cells, neutrophils. These images are captured using a bright field microscope and a confocal microscope.

Promotor: F. Arbab, R. De Nicola, Co-Promotor: M. Tribastone

This thesis covers various applications of topology in condensed matter physics and quantum information.

This thesis explored the molecular pharmacological mechanisms of targeting CB2R via investigation of novel drug discovery concepts such as target binding kinetics, allosteric modulation and biased signaling.

This thesis describes the implementation and on-sky demonstration of high-resolution integral-field spectroscopy for extreme adaptive optics systems that are used to find and characterize exoplanets.

In this thesis, we consider various (electro)chemical phenomena at surfaces and nanoparticles and their underlying atomistic processes, which we studied using first-principles methods such as density functional theory.

Despite being the second largest transmembrane protein family after GPCRs, the SLC superfamily has only gained significant attention in early drug development over the past decade.

In this thesis, we aim to shed light on the diverse and often opposing roles of integrin α3β1 in cancer.

The inverse electron demand Diels-Alder (IEDDA) pyridazine elimination emerged in 2013 as a new bioorthogonal reaction and constitutes a prime example of what is now known as dissociative bioorthogonal chemistry. The research described in this Thesis aims to develop synthetic strategies which enable…

Quantum computers are a proposed fundamentally new type of computer. They aim to perform some computations much faster than previously possible by exploiting phenomena at the quantum scale, called superposition and entanglement.

This thesis is about cosmological inflation and its relation to observations.

Promotores: P. Stevenhagen, L. van Geemen Co-promotor: R.M. van Luijk

Promotor: W. Jiskoot, Co-promotor: A. Kros

The thesis focuses on synthesis strategies in oligosaccharide campaigns, and the influence of protecting groups.

This thesis concerns the relation bettween the good reduction of Shimura varieties and the associated loop groups.

This thesis focused on the exploration of monolayer graphene as a membrane in direct methanol fuel cell (DMFC) applications, with improvements achieved through plasma exposure or damage- free chemical functionalization.

Gebruik en ontwikkel je talenten.

The largest genus within the Phyllanthaceae family is a group called Phyllanthus L. Recent studies have shown, that Phyllanthus is paraphyletic with the genera Glochidion, Breynia and Synostemon nested within it.

Promotor: G. A. van der Marel, Co-promotor: D. V. Filippov

My PhD research is devoted to studies of the conjectural cluster-algebraic symmetry in the theory of topological string, which is the simplest, however already non-trivial sector in the theory of string.

Een historische blik achter de betonnen schermen van de Amerikaans-Nederlandse betrekkingen.

This thesis describes the design, synthesis, and immunological evaluation of varying (neo)antigenic peptide conjugates containing either a TLR2 or a TLR7 agonist.

Promotor: Prof.dr. M. Franx, Co-Promotor: Rychard Bouwens

Kijk mee en praat mee over de wetenschap van het verleden tijdens wekelijkse Let’s Plays van populaire games en vodcasts op het livestreamplatform Twitch.

A new type of tripodal squaramide-based supramolecular hydrogels is developed and studied.

This thesis studies operator-algebraic aspects of subproduct systems, a generalization of product systems of Hilbert spaces.

Humans share meaning through language. Over time, repeated interactions have shaped languages into forms that match our cognitive preferences, making them structured, expressive, easy to learn, and ultimately, meaningful.

Lezing

Rembrandtroute ter gelegenheid van het 444-jarig bestaan van de Universiteit Leiden en het Rembrandtjaar 2019. Met speciale dank aan Germanisches Nationalmuseum (Neurenberg), The Leiden Collection (New York), Museum De Lakenhal (Leiden), Mauritshuis (Den Haag), Rijksmuseum/Musée du Louvre (Amsterdam/Parijs),…

In dit artikel presenteren Andrea Bartolucci en Michele Magni een evidence-based onderzoek naar de spontane opname van slachtoffers en de verdeling van patiënten in de onmiddellijke nasleep van de Manchester Arena Bombing.