Patterned detectors are an existing technology that can be found in almost all color cameras.

A common method to solve expensive function evaluation problem is using Bayesian Global Optimization, instead of Evolutionary Algorithms.

This thesis describes the synthesis and biological evaluation of TLR2/6, TLR4, TLR7/8 and TLR9 ligands, of which the activity can be conditionally controlled.

Astronomical observations of cold regions in the universe show a rich inventory of ices. Part of these ices may end up on planets like our own, but in that journey they will be exposed to considerable amounts of radiation.

The research of the Applied Mathematics cluster is concerned with such diverse topics as dynamical systems, representation theory, differential equations and pattern recognition.

Enzymes are innately sensitive to changes in the amino acid sequence, which largely constrains their evolutionary potential, i.e., evolvability. This evolutionary burden can be alleviated in the presence of stabilizing mutations, which increase the buffering capacity of enzymes to tolerate mutations…

Promotor: Christoph U. Keller, Co-promotores: Matthew A. Kenworthy, Frans Snik

Cancer is considered the silent pandemic of the 21st century and the second leading cause of death worldwide.

Promotor: H.P. Spaink, Co-Promotor: A.H. Meijer

Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…

The chemical and structural heterogeneity of toxoid vaccines makes their analysis challenging. However, detailed insights on a molecular level can be obtained by mass spectrometry.

Promotor: C.J. ten Cate, Co-promotor: H.W. Slabbekoorn

This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.

Producing green energy has become the main goal in our society in the search of reducing or eliminating the carbon emission from fossil fuels.

Promotor: F.H.J. Redig, Co-Promotor: W.T.F. den Hollander

Dark matter is one of the biggest mysteries of the Universe. Its properties cannot be explained with the known laws of physics and elementary particles.

Promotor: Prof.dr. G.P. van Wezel

Promotor: Prof.dr. T.H.W. Bäck

The radio sky harbours both galactic and extragalactic sources of arcminute- to degree-scale emission of various physical origins. To discover extragalactic diffuse emission in the Cosmic Web beyond galaxy clusters, one must image low–surface brightness structures amidst a sea of brighter compact fore-…

Vast, often populated, areas in dryland ecosystems face the dangers of desertification.

Promotor: F. Arbab

Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez

When observing star-forming galaxies, we are not only seeing stellar light, but we also see how this interacts with galactic gas and dust. This thesis contains studies of the stellar, nebular and dust properties of low mass star-forming galaxies.

Het onderzoeken van medische experimenten op mensen in de koloniale periode in Zuidoost-Azië.

Promotor: Prof.dr. S. Portegies Zwart

We have conducted a full spectral line survey of the 3-13 micron region of two massive protostars, AFGL 2591 and AFGL 2136, for the first time at high spectral resolution.

Op 11 november 2021 verdedigde Evelien Campfens het proefschrift 'Cross-border Claims to Cultural Objects'. Het promotieonderzoek is begeleid door prof.dr. N.J. Schrijver en prof.dr. W.J. Veraart (VU Amsterdam).

Protein–protein complexes are formed via transient states called encounter complexes that greatly influence the formation of the stereospecific complex.

Anthropogenic noise negatively affects wildlife in a wide range of taxonomic groups.

Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.

Promotor: J. Aarts

This dissertation presents the results of the importance of creativity for ICT-students of Dutch universities of applied sciences (in Dutch: hogescholen), and the functioning of training courses that aim to promote creative abilities is highlighted.

In today's volatile market environments, companies must be able to continuously innovate. In this context, innovation does not only refer to the development of new products or business models but often also affects the entire organization, which has to transform its structures, processes, and ways of…

The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.

The main goal of the research described in this thesis was the development of new photoactivated chemotherapy (PACT) ruthenium(II) complexes bearing a non-toxic photolabile ligand.

One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.

Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.

The effective treatment of tuberculosis (TB) remains a major challenge to global health.

Subproject of the ERC project 'Challenging the Liberal World Order from Within: The Invisible History of the United Nations and the Global South'.

This thesis describes the role of pollution, specifically neonicotinoid insecticides, as an actor of the ongoing biodiversity decline.

This research focuses on the distribution of chemical elements in protoplanetary disks, the birthplaces of planets. These disks form around young stars and contain gas and dust, from which planets grow. Ice plays a crucial role in planet formation, aiding the clumping of dust particles and influencing…

Promotores: Prof.dr. H. van Veen & Prof.dr. W. de Boer (Wageningen University)

Promotor: Bas Edixhoven, Promotor: Qing Liu

In this thesis, we describe the latest advances in SQUID-detected Magnetic Resonance Force Microscopy (MRFM).

De Faculteit der Wiskunde en Natuurwetenschappen is gevestigd op verschillende locaties in het Bio Science Park Leiden.

Op 13 januari 2022 verdedigde Pie Habimana het proefschrift 'Harmful Tax Competition in the East African Community'. Het promotieonderzoek is begeleid door prof.dr. H. Vording en prof.dr. S.C.W. Douma (UvA).

Statistical considerations guide the design and implementation of the experiments that scientists perform. For instance, in a clinical trial about a the efficacy of a treatment, its effect in a certain minimum amount of patients has to be observed in order to make confident assertions about the efficacy…

Tijdens de vroege moderne tijd werden veel middeleeuwse manuscripten in stroken perkament gesneden, die opnieuw werden gebruikt om de bindingen van nieuw gedrukte boeken te versterken. Tot voor kort kwamen deze hergebruikte stukjes middeleeuwse manuscripten alleen aan het licht wanneer de vroege moderne…

Viral hemorrhagic fever (VHF) is a group of acute diseases caused by highly infectious viruses including Ebola, Lassa, Dengue viruses. Its high mortality rate poses high risk to public health, however, studies on VHF have been hampered due to the non-availability of proper models and incomplete knowledge…

Increasing the efficiency of gene targeting (GT) as a genome editing tool in plants has been an important goal in plant biotechnology.